REBECCA LAMB WEISS: DR. NATHAN BRYAN,
WELCOME TO THE SHOW.
DR. NATHAN BRYAN: THANK YOU SO MUCH.
GREAT TO BE WITH YOU.
REBECCA: I AM SO EXCITED.
I REMEMBER I WAS ABLE TO BE ON AN INTERVIEW WITH YOU
ON ANOTHER SHOW, AND, MAN,
MY LITTLE WHEELS WERE TURNING BECAUSE THIS,
WHAT YOU'RE DOING IS SO IMPORTANT.
DR. BRYAN: THANK YOU.
I THINK SO.
[ LAUGHING ]
REBECCA: I THINK SO, TOO.
AND ONE OF THE THINGS I WAS THINKING ABOUT,
I WENT TO GOOD OLD ORAL ROBERTS UNIVERSITY,
AND THEY HAD THIS THING WHERE THEY WERE LIKE
WHOLE PERSON EDUCATION, AND IT WAS LIKE BODY, SOUL, AND SPIRIT.
AS BELIEVERS, WE SHOULD TAKE CARE OF ALL THREE.
BUT ONE OF THE THINGS I WAS THINKING ABOUT IS CHRISTIANS,
A LOT OF TIMES,
WILL FOCUS ON THE HEALTH OF OUR SOULS AND THE HEALTH SPIRITUALLY
BUT WILL REALLY NEGLECT THE HEALTH OF OUR BODIES.
AND IT REALLY CAN ACTUALLY CAUSE DAMAGE IN THE BODY OF CHRIST.
AND PEOPLE LEAVE US SOONER THAN THEY NEED TO.
SO WE REALLY NEED TO BE STEWARDING OUR BODIES.
DR. BRYAN: WE'RE A TEMPLE,
AND WE'VE GOT TO TAKE CARE OF IT.
WE HAVE TO -- OUR HEALTH IS OUR GREATEST ASSET.
WE CAN'T ENJOY THE HARVEST AND THE FRUITS OF OUR LABOR
IF WE DON'T HAVE GOOD HEALTH.
REBECCA: AND THERE REALLY IS AN ATTACK ON OUR HEALTH
IN OUR WORLD TODAY.
DR. BRYAN: AND IT'S BEEN GOING ON FOR DECADES.
AND I THINK CERTAINLY THE WAY THAT THE SO-CALLED EXPERTS
GUIDE US ON NUTRITION AND DRUG THERAPY
AND THE FOOD THAT WE'RE PRODUCING AND EATING
IS NOT FOR THE BENEFIT OF HUMAN HEALTH.
REBECCA: NO.
AND I'VE BEEN ON MY OWN PERSONAL HEALTH JOURNEY FOR YEARS NOW.
I THINK MAYBE SEVEN YEARS.
AND I USED TO HAVE A LOT OF FEAR,
AND I ALWAYS TRY TO TELL PEOPLE,
YOU CAN'T LIVE YOUR LIFE OUT OF FEAR.
THAT WILL DO MORE DAMAGE TO YOUR HEALTH.
BUT ONE OF THE THINGS I FELT LIKE THE LORD SHOWED ME
IS HE HAS DESIGNED OUR BODIES IN SUCH AN AMAZING WAY,
AND HE HAS DESIGNED OUR BODIES THAT THEY CAN HEAL.
THEY CAN HEAL THEMSELVES.
WE JUST NEED TO SUPPORT THE BODY IN THAT PROCESS.
DR. BRYAN: YEAH.
I THINK WHAT I'VE LEARNED IN 25 YEARS IN ACADEMIA AND MEDICINE
IS THAT PEOPLE GET SICK FOR TWO REASONS
AND TWO REASONS ONLY: THEIR BODY'S MISSING
SOMETHING THAT IT NEEDS OR IT'S EXPOSED TO SOMETHING
THAT IT DOESN'T NEED IN THE FORM OF A TOXIN.
SO IF WE CAN REPLETE MISSING NUTRIENTS
AND WE CAN RID THE BODY OF TOXINS OR EXPOSURE OF TOXINS,
THEN THE BODY HEALS ITSELF.
DOCTORS DON'T HEAL PATIENTS.
MEDICINE DOESN'T HEAL PATIENTS.
THE HUMAN BODY HEALS ITSELF.
WE'VE JUST GOT TO GET OUT OF THE WAY, RIGHT.
AND FOR ME, SPENDING 30 YEARS OR MORE NOW IN SCIENCE
AND PHYSIOLOGY AND TRYING TO UNDERSTAND
HOW THE HUMAN BODY WORKS, I THINK A LOT OF THE DISCOVERIES
I MADE EARLY ON WERE BECAUSE I MADE
A CONSCIOUS EFFORT TO HAVE A CONVERSATION WITH OUR CREATOR.
HOW CAN WE KNOW HOW THE BODY WORKS
IF WE DON'T HAVE A RELATIONSHIP WITH THE CREATOR?
REBECCA: AND I THINK THERE'S SUCH WISDOM IN THAT,
AND I THINK THAT I WANT TO TALK ABOUT THAT,
BECAUSE WHATEVER YOUR BELIEF IS AND WHATEVER YOUR WORLDVIEW
AND YOUR MORAL COMPASS,
THAT'S GOING TO AFFECT YOUR WORK.
AND SO THE PEOPLE WHAT WE WANT IN THE FIELD OF SCIENCE
AND MEDICINE ARE PEOPLE WHO HAVE A RELATIONSHIP WITH GOD
AND UNDERSTAND THAT WE ARE CREATED
AND HAVE A MORAL COMPASS BECAUSE SCIENCE,
APPLIED THE WRONG WAY, CAN DO SO MUCH DAMAGE.
DR. BRYAN: YEAH, I THINK WE'VE LIVED THROUGH THAT RIGHT NOW.
REBECCA: YEAH.
WE'VE SEEN SOME OF THE FRUITS OF THAT.
SO TELL OUR AUDIENCE A LITTLE BIT OF YOUR STORY.
DR. BRYAN: I'M A SMALL TOWN TEXAS BOY.
I GREW UP IN A VERY RURAL, SMALL COMMUNITY
JUST OUTSIDE OF AUSTIN.
CAME FROM A DIVORCED HOME.
MY PARENTS SEPARATED AND DIVORCED WHEN I WAS YOUNG,
4 OR 5 YEARS OLD.
AND THEN WHEN I WAS I GUESS 10,
MY DAD SUFFERED A VERY SERIOUS CAR ACCIDENT
THAT LEFT HIM PARALYZED FROM THE WAIST DOWN,
AND MY BROTHER AND I WERE LIVING WITH MY DAD AT THAT TIME.
AND HE WAS SELF-EMPLOYED, SO NO INSURANCE.
FORTUNATELY, HE SURVIVED, BUT IT LEFT HIM PARALYZED
FROM THE WAIST DOWN AND UNABLE TO WORK.
SO AT 10 AND 11 YEARS OLD, MY BROTHER AND I HAD TO GO TO WORK
TO PAY THE BILLS AND SUPPORT THE FAMILY
WHILE DAD WAS IN THE HOSPITAL AND REHAB.
AND SO WE DEVELOPED A STRONG SENSE OF INDEPENDENCE
WITH THIS ATTITUDE OF DO WHATEVER IT TAKES.
IT'S NEXT MAN UP.
AND SO THEN I SAW THE MEDICAL SYSTEM FAIL MY DAD.
JUST POOR HEALTH, POOR MEDICAL CARE,
NON-HEALING WOUNDS, ULCERS,
UNCONTROLLED DIABETES, HYPERTENSION.
REBECCA: OH, MY GOODNESS.
DR. BRYAN: AND SO WHEN I WAS IN HIGH SCHOOL,
MY DAD RECOVERED AND HE WENT TO WORK AT A DIFFERENT CITY,
AND MY BROTHER AND I DIDN'T WANT TO MOVE,
SO WE GOT OUR OWN APARTMENT AND FINISHED HIGH SCHOOL.
MY BROTHER GRADUATED, THEN I SPENT THE LAST TWO YEARS
OF HIGH SCHOOL LIVING IN MY OWN APARTMENT.
AND HAD TWO JOBS WORKING AFTER HIGH SCHOOL
AND WAS PRETTY INDEPENDENT FROM THE TIME I WAS 16 YEARS OLD.
REBECCA: THAT IS IMPRESSIVE.
DR. BRYAN: BUT I WAS BLESSED WITH A GIFT,
IF I WRITE SOMETHING, I SEE SOMETHING,
I REMEMBER IT.
SO I DID VERY WELL IN SCHOOL.
I MADE GOOD GRADES AND GRADUATED AT THE TOP OF MY CLASS,
AND THEN I WENT TO THE UNIVERSITY OF TEXAS AT AUSTIN.
AND AS A SMALL NAIVE COUNTRY KID,
ALL MY COUNSELORS SAID, YOU SHOULD BE AN ENGINEER.
I'M LIKE, OKAY, WHATEVER.
SO I ENROLLED IN ENGINEERING AT UT.
AND THEN AFTER THE FIRST SEMESTER,
I GO TO MY COUNSELOR AND I GO, WHAT DO ENGINEERS DO?
WELL, THEY BUILD ROADS AND BRIDGES AND STRUCTURES.
AND I GO, BUT THAT'S NOT WHAT I WANT TO DO.
SO I ENTERED THE BIOCHEMISTRY PROGRAM
IN THE COLLEGE OF NATURAL SCIENCE
AND PURSUED A DEGREE IN BIOCHEMISTRY.
REBECCA: WHAT TOOK YOU THERE?
DR. BRYAN: REALLY JUST, AGAIN,
I THINK MY DAD WAS MY INSPIRATION,
TRYING TO UNDERSTAND HOW THE HUMAN BODY WORKS.
I TOOK PHYSIOLOGY COURSES AND FELL IN LOVE WITH
THE SCIENCE AND BIOLOGY AND BIOCHEMISTRY OF HUMAN SYSTEMS.
AND THEN ONCE I HAD A DEGREE IN BIOCHEMISTRY,
I THOUGHT I WOULD ACHIEVE MY GOALS AND TRIED TO FIND A JOB.
THERE WERE NO JOBS.
[ LAUGHING ]
AND SO I ENROLLED AT LSU SCHOOL OF MEDICINE AND GOT A PH.D.
IN MOLECULAR AND CELLULAR PHYSIOLOGY,
AND THAT WAS WHEN I WAS INTRODUCED TO THIS WHOLE SCIENCE
OF NITRIC OXIDE.
REBECCA: SO YOU STUDIED,
IN LAYMAN'S TERMS, BASICALLY HOW OUR CELLS WORK?
DR. BRYAN: THAT'S EXACTLY RIGHT.
AND I THINK I WOULD ADVOCATE,
IF I COULD ADVOCATE AND CHANGE ANYTHING,
IF YOU'RE GOING TO GO AND BE A PHYSICIAN,
I THINK YOU HAVE TO HAVE A STRONG BACKGROUND
IN BIOCHEMISTRY, RIGHT.
HOW DO PROTEINS AND ENZYMES WORK TO FILL
THE ENERGY OF THE CELL ON THE BODY?
AND THEN PHYSIOLOGY IS AN ALL-ENCOMPASSING FIELD
WHERE IT UNDERSTANDS HOW DOES GOING FROM
THE SUBCELLULAR ORGANELLE-TYPE MODEL TO CELLULAR BIOLOGY
TO ORGAN SYSTEMS TO HUMAN PHYSIOLOGY,
HOW DOES ALL THAT INTEGRATE
AND HOW DO THEY TIE INTO ONE ANOTHER?
BECAUSE I THINK ONCE YOU HAVE A FIRM UNDERSTANDING OF THAT,
THEN YOU CAN START TO INTERROGATE
SYSTEMS THAT FAIL WHEN PEOPLE GET SICK.
RIGHT.
AND SO NOT JUST TREATING, WHICH IS CONVENTIONAL MEDICINE TODAY.
ALL WE DO IS TREAT SYMPTOMS.
YOU HAVE A SYMPTOM, YOU TAKE A DRUG FOR THE SYMPTOM.
BUT NOBODY'S ADDRESSING, WHY DID YOU GET CANCER?
WHY DO YOU HAVE HEART DISEASE?
WHY DO YOU HAVE ERECTILE DYSFUNCTION?
WHY DO YOU HAVE HIGH BLOOD PRESSURE?
THEY WANT TO GIVE YOU DRUGS TO AFFECT IT,
BUT NOT UNDERSTANDING WHAT MAY BE CONTRIBUTING TO
THE ROOT CAUSE OF THAT OR THE SYMPTOMS THAT DEVELOP
FROM FAILED SYSTEMS.
REBECCA: AND THAT'S WHY OUR HEALTHCARE SYSTEM,
THE MEDICAL SYSTEM, IS BROKEN AND WHY SO MANY PEOPLE
END UP KIND OF LIKE YOUR DAD,
THEY END UP GETTING SOMETIMES WORSE THAN BETTER
BECAUSE THEY DIDN'T GET THE BEST TREATMENT
BECAUSE THE SYSTEM IN AND OF ITSELF
IS NOT MAYBE THE BEST SYSTEM.
DR. BRYAN: WELL, I WAS IN THAT SYSTEM FOR 20 YEARS
AS A STUDENT.
AND THEN I TAUGHT WHAT'S CALLED PATIENT-ORIENTED PROBLEM-SOLVING
TO MEDICAL STUDENTS.
AND THEN WHEN I WAS ON FACULTY AT UT,
WE TAUGHT FUTURE PHYSICIANS.
IT'S A TEACHING, IT'S A MEDICAL SCHOOL,
A TEACHING SYSTEM.
AND FOR ME, THE EPIPHANY WAS, LOOK,
WE DO A GOOD JOB OF TEACHING ANATOMY,
PHYSIOLOGY, BIOCHEMISTRY AND THE BASIC CORE SCIENCES.
BUT THEN THE WAY THE CURRICULUM WORKS IS,
THOSE NEXT TWO YEARS,
YOU GO OFF AND YOU'RE DOING CLINICAL ROTATIONS
AND YOU'RE LEARNING THE PRACTICE OF MEDICINE.
DIAGNOSING, ICD-10 CODES.
AND THEN ONCE YOU MAKE A DIAGNOSIS,
HERE'S YOUR RECIPE FOR HOW YOU TREAT THEM.
AND IF YOU VENTURE OUTSIDE OF THAT,
YOU'RE NOT PRACTICING THE STANDARD OF CARE,
AND IT COULD PUT YOUR LICENSE AT RISK.
REBECCA: YEAH.
DR. BRYAN: AND THEN THE EPIPHANY, WELL,
WHY IS THIS?
AND THEN MEDICINE IS A BUSINESS.
IT IS A FOR-PROFIT BUSINESS.
AND AS AN ENTREPRENEUR AND AS A CAPITALIST,
THE NUMBER ONE RULE OF BUSINESS IS,
GET A CUSTOMER AND KEEP THAT CUSTOMER AS LONG AS YOU CAN.
THAT'S EVERYBODY'S GOAL.
AND MEDICINE IS THE BEST BUSINESS OUT THERE.
IT'S A TRILLION-DOLLAR INDUSTRY.
AND ONCE THEY GET A CUSTOMER,
THEY PUT YOU ON THAT HAMPSTER WHEEL AND YOU NEVER GET OFF.
AND IT'S NEVER, HOW DO WE GET YOU OFF OF THESE DRUGS?
IT'S YOU'RE GOING TO DEVELOP THIS SYMPTOM,
I'M GOING TO PUT YOU ON ANOTHER DRUG.
THAT DRUG'S GOING TO CAUSE A SYMPTOM,
I'M GOING TO PUT YOU ON ANOTHER DRUG.
AND NOW THE LIFETIME VALUE OF THAT CUSTOMER
IS THE BEST BUSINESS MODEL IN THE WORLD.
AND THAT'S THE PROBLEM.
REBECCA: YEAH, IT IS.
AND ONCE PEOPLE CAN -- THAT'S THE FIRST STEP
IN GETTING PEOPLE I THINK TO UNDERSTAND WELLNESS
IS UNDERSTANDING WHERE THE SYSTEM IS BROKEN
AND BEING AWARE OF THAT, AND THEN MOVING FORWARD TOO.
AND I THINK THAT FIRST POINT THAT YOU SAID IS SO IMPORTANT,
THAT ALL SICKNESS COMES FROM EITHER TOXINS
OR A LACK OF NUTRITIONAL DEFICIENCIES, RIGHT?
DR. BRYAN: THAT'S RIGHT.
REBECCA: THAT'S RIGHT.
THAT'S ACTUALLY VERY HELPFUL TO TELL PEOPLE.
DR. BRYAN: WHEN YOU IMPLEMENT THAT PHILOSOPHY,
WE'RE NEVER DEFICIENT IN CHOLESTEROL-LOWERING MEDICATION.
WE'RE NEVER DEFICIENT IN SYNTHETIC COMPOUNDS
THAT INHIBIT BIOCHEMICAL REACTIONS.
IN FACT, THEY'RE CAUSING TOXICITY.
AND MANY OF THEM LEAD TO NUTRIENT DEFICIENCIES.
SO IT'S CONTRIBUTING TO THE CYCLE OF CHRONIC DISEASE.
AND THAT'S WHY AMERICANS ARE THE SICKEST PEOPLE ON THE PLANET
BECAUSE WE DON'T ADDRESS THE ROOT CAUSE.
REBECCA: YEAH.
AND THEN WHEN YOU GO INTO, LIKE YOU SAID, OUR FOOD,
OUR WATER, WHAT THEY'VE DONE TO OUR SOIL,
WHICH IS AFFECTING OUR FOOD,
THE STUFF THAT'S IN OUR AIR,
THE STUFF THAT'S IN OUR WATER IS FULL OF SO MANY THINGS.
THERE'S SO MANY DIFFERENT WAYS FOR BEING BOMBARDED CHEMICALLY.
AND HONESTLY MOST PEOPLE AREN'T EVEN AWARE OF IT,
OUR PRODUCTS THAT WE USE IN OUR HOMES EVERY SINGLE DAY,
WE ARE REALLY BOMBARDING OUR BODIES WITH --
AND THEN WE'RE NOT DETOXING WELL,
BECAUSE WE DON'T EVEN KNOW HOW TO DETOX.
DR. BRYAN: NO, LOOK.
WE DETOX THROUGH BREATHING, URINATION,
DEFECATION, AND SWEATING.
REBECCA: AND SWEATING.
DR. BRYAN: AND NOBODY SWEATS ANYMORE, RIGHT.
REBECCA: NO ONE SWEATS.
AND MOST PEOPLE HAVE PROBLEMS USING THE BATHROOM.
MOST PEOPLE ARE CONSTIPATED.
I MEAN, I'M SORRY.
MOST PEOPLE ARE CONSTIPATED.
DR. BRYAN: YEAH.
AND SO YOU GET TOXINS THAT BUILD UP THAT YOU CAN'T GET RID OF.
REBECCA: EXACTLY.
AND PEOPLE AREN'T EVEN AWARE OF IT.
YEAH.
AND SO THIS IS WHY WHAT YOU'RE DOING WITH NITRIC OXIDE
IS SO IMPERATIVE.
AND WHAT I LOVE ABOUT IT IS BECAUSE YOU'RE NOT
CREATING SOMETHING SYNTHETIC TO TREAT A SYMPTOM,
WHICH IS YOU SAID THE WORD...
DR. BRYAN: PHARMACOLOGY.
PHARMACOLOGY IS THE APPLICATION OF
USUALLY SYNTHETIC COMPOUNDS THAT ARE TARGETED TO A SPECIFIC,
WHAT I CALL A SYMPTOMOLOGY OF A DISEASE,
RIGHT.
SO THE BEST EXAMPLE WOULD BE CHOLESTEROL-LOWERING MEDICATION,
RIGHT.
OUR BODY NATURALLY PRODUCES CHOLESTEROL.
WHY?
BECAUSE OUR BODY NEEDS IT.
AND SO WHEN YOU DEVELOP A COMPOUND THAT INHIBITS
THE VERY LIMITING STEP OF CHOLESTEROL SYNTHESIS,
THEN THAT'S PHARMACOLOGY.
IT'S TARGETED TO
SPECIFICALLY INHIBIT THAT BIOCHEMICAL REACTION.
AND WHEN YOU INTERRUPT NATURAL PROCESSES,
WHEN YOU INTERRUPT NATURE AND INTERFERE WITH NATURE,
THERE'S ALWAYS SIDE EFFECTS.
REBECCA: YEAH, IT'S TRUE.
DR. BRYAN: AND THAT'S WHY MOST DRUGS AREN'T SAFE.
THERE'S ALWAYS SIDE EFFECTS.
REBECCA: BUT YOURS IS DIFFERENT.
WHAT DO YOU DESCRIBE YOURS AS?
DR. BRYAN: YEAH.
SO WHAT WE DO IS RESTORE TO PHYSIOLOGY, RIGHT.
WE DON'T USE SYNTHETIC COMPOUNDS,
WE DON'T MANUFACTURE AND DEVELOP COMPOUNDS THAT WE CAN PATENT.
I HAVE A NUMBER OF PATENTS,
BUT THEY'RE NOT ON NOVEL STRUCTURES OF MATTER.
BUT WHAT WE DO IS UNDERSTAND WHAT GOES WRONG IN PEOPLE,
AND THEN HOW DO WE FIX IT.
AND WE SPOKE SPECIFICALLY ON NITRIC OXIDE.
SO NUMBER ONE, I HAD TO UNDERSTAND HOW THE HUMAN BODY
MAKES NITRIC OXIDE.
NUMBER TWO, SPENT 20 YEARS TRYING TO UNDERSTAND
WHAT LEADS TO A LOSS OF NITRIC OXIDE PRODUCTION.
WHAT LEADS TO THE INABILITY TO NATURALLY PRODUCE
THIS VERY CENTRAL FOUNDATIONAL MOLECULE.
AND THEN ONCE WE HAD ANSWERS TO THOSE QUESTIONS,
THEN I FIGURED OUT, OKAY,
NOW THAT I UNDERSTAND THAT,
I CAN START TO DEVELOP RATIONAL THERAPY.
AND SO WHAT WE DO IS, AGAIN,
HOW MUCH NITRIC OXIDE ARE YOU MAKING?
WE WANT TO GIVE BACK WHAT'S MISSING.
THE BEST EXAMPLE OF THIS IS VITAMIN D, RIGHT.
VITAMIN D'S SIMPLE.
YOU GO GET A BLOOD DRAW, AND IF YOUR VITAMIN D'S 20,
YOU TAKE VITAMIN D UNTIL YOUR BLOOD LEVELS GET TO 80.
SO THAT'S THE EASY WAY TO TRY TREATING IT.
THE PROBLEM WITH NITRIC OXIDE IS, IT'S A GAS.
NUMBER ONE, WE CAN'T PICK IT UP IN YOUR BLOOD
IN A CLINICAL SETTING.
AND SO WE HAVE TO RELY ON SYMPTOMS AND UNDERSTANDING
HOW MUCH NITRIC OXIDE A HEALTHY PERSON MAKES IN 24 HOURS
THROUGH THE PRODUCTION PATHWAYS.
SO MY GOAL WAS, LET'S GIVE BACK WHAT'S MISSING,
AND THEN LET'S FIX THE REASON YOUR BODY'S LOST
THE ABILITY TO PRODUCE IT NATURALLY.
AND THAT'S WHAT I FOCUSED ON FOR THE PAST 25 YEARS.
REBECCA: SO HOW DID YOU GET INTRODUCED TO NITRIC OXIDE,
WE'LL START THERE, AND THEN I WANT TO HEAR
WHAT DOES NITRIC OXIDE DO IN THE BODY
AND WHY IT'S SO FOUNDATIONAL FOR OUR HEALTH?
DR. BRYAN: WELL, I THINK I WAS A FIRST-YEAR STUDENT
AT LSU SCHOOL OF MEDICINE.
A NOBEL PRIZE HAD JUST BEEN AWARDED,
AND THIS WAS 1998 FOR THE DISCOVERY OF NITRIC OXIDE
AS A SIGNALING MOLECULE IN THE CARDIOVASCULAR SYSTEM.
SO, OBVIOUSLY, EVERY YEAR IN, I BELIEVE IT'S AUGUST,
THE NOBEL PRIZE IS AWARDED,
AND THEN THE PRIZE IS -- OR ANNOUNCED,
AND IT'S AWARDED, I THINK, IN DECEMBER.
SO THE GUY THAT WON THE NOBEL PRIZE,
THERE WERE THREE SCIENTISTS,
AND ONE OF THEM, LOU IGNARRO, CAME TO THE MEDICAL SCHOOL
AND GAVE A LECTURE AND TOLD ABOUT HIS STORY OF DISCOVERY
AND JOURNEY AND WHAT LED TO A NOBEL PRIZE.
AND HE SAID TO ME, HE GOES, NATHAN, IF WE CAN FIGURE OUT
HOW TO SAFELY AND EFFECTIVELY RESTORE NITRIC OXIDE PRODUCTION
IN THE HUMAN BODY,
IT'LL CHANGE THE WORLD.
AND IT'LL CHANGE THE MANAGEMENT OF DISEASE,
BECAUSE THERE'S NOT A SINGLE HUMAN DISEASE
WHERE NITRIC OXIDE WOULDN'T BE BENEFICIAL.
AND I GO, THAT'S A PRETTY PROFOUND STATEMENT.
SO FORTUNATELY, I TRAINED UNDER A PHARMACOLOGIST,
MARTIN FEELISCH HAD BEEN IN THE NITRIC OXIDE FIELD
FOR 20 YEARS PRIOR.
AND WE DEVELOPED ANALYTICAL METHODS
WHERE WE COULD DETECT NITRIC OXIDE GAS IN BIOLOGICAL SYSTEMS.
AND THAT NOW CREATED FOR US WHAT WE CALLED
A FINGERPRINT OF INNOBIOLOGY,
HEART DISEASE, DIABETES, TRANSPLANT SURGERIES,
THINGS LIKE THAT.
AND SO THEN THAT ALLOWED ME TO FIGURE OUT HOW TO
MAKE NITRIC OXIDE, RIGHT.
BECAUSE NITRIC OXIDE'S A GAS,
AND ONCE IT'S PRODUCED, IT'S GONE IN LESS THAN A SECOND.
SO PART OF MY CHALLENGE WAS,
WHEN NITRIC OXIDE'S PRODUCED,
WHERE DOES IT GO, WHAT DOES IT BECOME,
AND THEN WHAT DOES IT DO?
AND THEN ONCE WE FIGURE THAT OUT, THEN I THOUGHT,
OKAY, WELL, NOW IF I MAKE NITRIC OXIDE,
I CAN CONTROL AND DICTATE THE METABOLIC FATE OF NITRIC OXIDE,
NOW I CAN DEVELOP SAFE AND EFFECTIVE THERAPIES.
SO THOSE WERE --
THERE WAS MULTIPLE DISCOVERIES OF EPIPHANIES
ALONG THE WAY IN MY SCIENCE CAREER AND DISCOVERY
THAT ALLOWED ME TO THINK A LITTLE BIT DIFFERENTLY.
YOU KNOW, THERE'S A FAMOUS QUOTE SAYING,
RESEARCH IS TO SEE WHAT OTHERS ARE SEEING
AND TO THINK WHAT NO ONE ELSE HAS THOUGHT.
AND THAT'S ALWAYS BEEN LIKE ADDING PRINCIPLE.
BECAUSE THERE'S A LOT OF NOISE OUT THERE.
SO I CAN SEE WHAT EVERYONE ELSE IS SEEING,
BUT I HAD TO THINK A LITTLE BIT DIFFERENTLY
AND THINK WHAT NO ONE ELSE HAS THOUGHT.
AND WHEN I SAID I COULD MAKE A SOLID DOSE FORM
OF NITRIC OXIDE GAS, PEOPLE SAID IT WASN'T POSSIBLE.
YOU'RE TRYING TO DO THE IMPOSSIBLE
AND YOU'RE GOING TO KILL PEOPLE.
SO I IGNORED THE NOISE AND KEPT MY HEAD DOWN
AND FOCUSED ON WHAT I KNEW WAS IMPORTANT.
AND WE'VE PROVEN A LOT OF THE DISBELIEVERS WRONG.
REBECCA: I THINK THAT'S SO IMPORTANT, TOO,
AND I THINK ANYONE THAT'S EVER CHANGED HISTORY
OR HAS MADE AN IMPACT, THEY HAD TO HAVE THAT KIND OF MENTALITY,
BECAUSE YOU'RE HAVING TO PIONEER AND PAVE A WAY
THAT NO ONE -- AND A LOT OF TIMES,
PEOPLE ARE LIKE, YOU'RE CRAZY.
AND IF YOU CARE TOO MUCH WHAT PEOPLE THINK,
YOU'RE GOING TO STOP WHAT YOU'RE DOING
AND THINK ABOUT EVERYTHING THAT'S HAPPENED
BECAUSE YOU KEPT MOVING FORWARD.
WHAT DO YOU THINK WAS ONE OF THE THINGS THAT PROPELLED YOU?
DR. BRYAN: THE DOUBT.
I'M PROBABLY ONE OF THE HARD-HEADEST PEOPLE
THAT MY PARENTS TELL ME, EVERYBODY TELLS ME THIS.
BUT IT WAS THE DOUBT.
I BELIEVED THAT WHEN PEOPLE -- THE WORST THING YOU CAN DO
IS TELL ME NO.
BECAUSE I'M GOING TO BE PRETTY MOTIVATED TO PROVE YOU WRONG,
AND WHEN PEOPLE STARTED DOUBTING WHAT I WAS DOING,
TOLD ME COULDN'T BE DONE OR THERE WERE TOO MANY --
REBECCA: YOU USED IT AS LIKE FUEL TO PUSH YOU FURTHER?
DR. BRYAN: IT'S FUEL.
IT FUELED THE FLAME.
REBECCA: THAT'S GOOD.
SO THAT'S TO PARENTS, TOO, IF YOU'RE WATCHING THIS
AND IF YOU HAVE A KID LIKE THAT, THAT'S ACTUALLY,
I THINK SOMETIMES PEOPLE ARE LIKE, UGH,
AND I'M LIKE, NO, THAT'S NOT --
DR. BRYAN: FEAR TO FAIL.
FEAR OF FAILURE.
I'M NOT FEARFUL OF FAILURE.
MY FEAR IS IN FEAR OF DISAPPOINTMENT
AND FEAR OF LETTING PEOPLE DOWN,
BUT IT'S NEVER BEEN A FEAR OF FAILURE,
AND I THINK WE HAVE TO TRAIN OUR KIDS TO,
IF YOU HAVEN'T FAILED, YOU HAVEN'T TRIED, RIGHT.
FAILURE IS A VERY IMPORTANT LESSON IN LIFE.
BUT IT'S NOT -- FAILURE'S NOT FALLING DOWN,
IT'S HOW MANY TIMES YOU FALL,
IT'S HOW MANY TIMES YOU GET UP.
RIGHT.
AND SO FOR ME, THAT WAS A DRIVER.
AND THE OTHER THING, I READ A LOT AS A KID,
AND EVEN WHEN I WAS GOING THROUGH SCHOOL,
AND ONE OF THESE, SCHOPENHAUER,
HE'S A GERMAN PHILOSOPHER, AND HE SAID THAT WHEN YOU
ESTABLISH A TRUTH, AND SO THESE ARE FUNDAMENTAL TRUTHS,
RIGHT, ALL TRUTHS GO THROUGH THREE PHASES.
FIRST, THEY'RE RIDICULED.
THEN SECONDLY THEY'RE VIOLENTLY OPPOSED.
AND THEN THIRD, THEY'RE REVEALED AS BEING SELF-EVIDENT.
SO WHEN I WAS GOING THROUGH THESE DISCOVERIES,
I KNEW THAT THESE WERE FUNDAMENTAL TRUTHS.
THESE WERE TRUTHS OF PHYSIOLOGY AND HOW THE HUMAN BODY WORKS.
SO, NUMBER ONE, I SURVIVED THE RIDICULE.
ALL MY ACADEMIC COLLEAGUES RIDICULED ME.
THERE WAS A VIOLENT OPPOSITION.
IT'S A COMPLETE VIOLENT OPPOSITION FROM COMPETITORS,
FROM BIG COMPANIES.
I'VE BEEN SUBJECT OF MULTIPLE LAWSUITS
TRYING TO DEPLETE ME OF MY RESOURCES,
TRYING TO DRAIN US FINANCIALLY
AND KEEP WHAT WE'RE DOING FROM GETTING OUT THERE
AND REVEALING THE TRUTH.
BUT I'VE BEEN RIDICULED, I'VE BEEN VIOLENTLY OPPOSED.
WHAT'S THE NEXT STEP?
IT'S SELF-EVIDENT.
REBECCA: YEAH.
DR. BRYAN: AND THAT'S -- WE'RE ENTERING THIS THIRD PHASE
OF THESE TRUTHS THAT WE'VE DISCOVERED.
REBECCA: YEAH.
AND PEOPLE ARE STARTING TO SEE THE BENEFITS.
AND GOD HAS TO BE BEHIND IT, TOO,
BECAUSE I THINK TOO IN SOMEONE THAT'S LIKE,
IF YOU'RE A DAVID AND YOU'RE FACING A GOLIATH,
ONLY GOD CAN LIKE SUSTAIN YOU.
DR. BRYAN: THAT'S RIGHT, HE'S MY SLINGSHOT.
REBECCA: YEAH.
THAT'S RIGHT.
THAT'S AWESOME.
THAT'S SO COOL.
I LOVE THAT.
I'M ALWAYS INSPIRED.
AND IT'S INSPIRING TO ME TO HEAR STORIES OF PEOPLE WHO PERSEVERE,
BECAUSE I THINK OTHER PEOPLE,
THEY'LL PERSEVERE,
BUT THEN THEY ALLOW THEMSELVES TO GET INTIMIDATED.
AND I WAS TALKING TO MY HUSBAND THIS MORNING
ABOUT THAT STORY IN THE BIBLE WHERE HE TELLS HIS PEOPLE
TO GO INTO THE PROMISED LAND AND THEY GO, WELL,
THERE'S GIANTS IN THERE.
AND SO A WHOLE GENERATION WEREN'T ABLE TO ENTER
UNTIL ONLY JOSHUA AND CALEB,
THEY WERE THE ONLY TWO THAT SAID, WE CAN DO THIS.
GOD'S ON OUR SIDE.
SO YOU HAVE TO HAVE THAT MENTALITY THAT IF GOD IS FOR US,
WHO CAN BE AGAINST US?
DR. BRYAN: YEAH, FOR SURE.
LOOK, THERE HASN'T BEEN A DAY I DIDN'T WAKE UP IN PRAYER
AND GRATITUDE.
AND EVEN THE DIMMEST OF TIMES AND THE DARKEST OF TIMES
AND THE SLIMMEST TIMES FINANCIALLY WITH NO RESOURCES
AND REALLY BETTING THE FARM,
BETTING EVERYTHING WE HAD, ON THIS DREAM
AND THIS VISION I HAD.
AND THEN TO JUST, IF IT'S MEANT TO BE, BELIEVE ME,
GOD, YOUR WILL BE DONE, NOT MINE.
AND IT'S JUST, IT'S GUIDED ME OF GIVING ME DIRECTION
AND GIVING ME REALLY CONFIDENCE TO KNOW THAT
WHAT WE'RE DOING IS THE RIGHT THING BECAUSE WHAT I RECOGNIZED
EARLY ON IS THE BENEFIT AND THE POWER OF NITRIC OXIDE.
TREATING MY DAD'S NON-HEALING WOUNDS,
GETTING HIM OFF PRESCRIPTION MEDICATION,
BLOOD PRESSURE MEDICINE, THIS PEDIATRIC PATIENT
WE PUBLISHED ON A TEXAS CHILDREN'S HOSPITAL IN 2011,
SAVING HIS LIFE WHEN ALL PRESCRIPTION MEDICATION FAILED
AND HE WAS IN A HYPERTENSIVE CRISIS
AND WE JUST GAVE HIM OUR NITRIC OXIDE,
SAVED HIS LIFE, IMPROVED HIS COGNITION,
IT REVERSED HIS HEART DISEASE,
REVERSED HIS KIDNEY DISEASE.
REBECCA: THAT'S AMAZING.
DR. BRYAN: AND THEN NOW,
EVERY DAY WHEN I WAKE UP, I'VE GOT HUNDREDS OF TEXTS,
EMAILS, AND VOICE MAILS OF, YOU'VE SAVED MY LIFE, THANK YOU.
THERE'S NOTHING MORE GRATIFYING THAN BEING
INVOLVED IN CHANGING SOMEONE'S LIFE.
AND CERTAINLY IT'S SAID IF YOU'VE CHANGED
ONE PERSON'S LIFE, YOU'VE CHANGED THE WORLD
AND YOU'VE CHANGED THEIR WORLD, FOR SURE.
SO THAT'S MY GUIDING LIGHT, MY PRINCIPLE.
BUT IT'S ALL, IT'S DIVINE INTERVENTION
BECAUSE WHEN I LOOK AT WHERE I AM, WHERE I'VE BEEN,
AND PERHAPS EVEN WHERE I'M GOING,
IT'S ALL -- I COULDN'T HAVE SCRIPTED THIS.
IT CERTAINLY HAD BEEN GOD LEADING ME ALONG THE WAY.
REBECCA: SOMEONE'S GUIDING ME.
DR. BRYAN: TEACHING ME A LOT OF LESSONS ALONG THE WAY, TOO.
REBECCA: I KNOW.
AND IT'S ALWAYS IN THE HARDEST THINGS, USUALLY,
THE BEST LESSONS ARE LEARNED.
SO NITRIC OXIDE, WHAT IS IT, WHY IS IT IMPORTANT?
DR. BRYAN: WELL, IT'S WHAT WE CALL A SIGNALING MOLECULE.
SO IT'S HOW CELLS IN THE BODY COMMUNICATE WITH ONE ANOTHER.
AND THE BEST EXAMPLE IS IN THE LINING OF THE BLOOD VESSEL.
SO THERE'S THIS SINGLE LAYER OF CELLS IN THE BLOOD VESSEL
CALLED ENDOTHELIAL CELLS.
PRODUCE NITRIC OXIDE, IT DIFFUSES INTO THE SMOOTH MUSCLE,
AND IT CAUSES SMOOTH MUSCLE RELAXATION,
AND BLOOD VESSELS DILATE.
SO NOW WE'RE IMPROVING BLOOD FLOW AND TISSUE OXYGENATION.
BUT IT ACTUALLY CONTROLS HOW OXYGEN IS DELIVERED
ON THE HEMOGLOBIN MOLECULE.
IT REGULATES THE UPTAKE AND DELIVERY OF OXYGEN.
BUT IT'S MUCH MORE THAN A VASAL DILATER.
IT MOBILIZES OUR STEM CELLS,
IT ACTIVATES OUR MITOCHONDRIA
SO THAT WE CAN IMPROVE ENERGY PRODUCTION
AT THE CELLULAR LEVEL.
REBECCA: THAT'S MAJOR.
DR. BRYAN: IT PREVENTS OUR TELOMERES,
THE ENDS OF OUR CHROMOSOMES,
FROM GETTING SHORTER, SO IT EXTENDS LIFE SPAN.
WHAT ELSE DOES IT DO.
IT IMPROVES PERFORMANCE, IMPROVES COGNITION.
WE TALK ABOUT PERFORMANCE, WE TALK ABOUT ATHLETIC PERFORMANCE.
IT'S A GREAT ERGOGENIC AID IN IMPROVING PERFORMANCE.
IT'S A COGNITIVE PERFORMANCE BOOSTER.
IT IMPROVES BLOOD FLOW TO THE BRAIN,
IMPROVES GLUCOSE UPTAKES.
WE CAN RECALL MEMORY AND SHARPER MIND.
AND IT IMPROVES SEXUAL PERFORMANCE.
IT'S ALL ABOUT IMPROVING BLOOD FLOW
AND OPTIMIZING HUMAN PERFORMANCE.
REBECCA: YEAH.
AND I KNOW FROM JUST MY OWN LITTLE BIT OF RESEARCH AND STUDY
THAT THE MITOCHONDRIA OF OUR CELLS,
THE POWER HOUSE OF OUR CELLS,
IF WE CAN IMPROVE THAT, THAT IMPACTS OUR HEALTH
ON A HUGE SCALE.
JUST THAT ONE THING.
DR. BRYAN: YEAH, LOOK, YEAH,
IT IS THE -- SO EVERY CHRONIC DISEASE
ASSOCIATED WITH LOWER NUMBERS OF MITOCHONDRIA PER CELL
AND WHAT MITOCHONDRIA THERE, THEY'RE INEFFICIENT.
RIGHT.
SO THEY GO FROM AN EFFICIENCY OF, SAY,
36 MILES TO GALLON TO 4 MILES PER GALLON
OR 2 MILES PER GALLON.
SO WHAT NITRIC OXIDE DOES IS IT RECOUPLES
THE ELECTRON TRANSPORT CHAIN, SO IT IMPROVES
THE EFFICIENCY OF ENERGY PRODUCTION WITHIN THE CELL.
AND MORE IMPORTANTLY, IT INDUCES MITOCHONDRIAL BIOGENESIS.
SO IF YOU MAKE SUFFICIENT NITRIC OXIDE,
IT TELLS THAT CELL, I NEED TO MAKE MORE MITOCHONDRIA,
SO YOU HAVE MORE MITOCHONDRIA GENERATING
MORE ENERGY MORE EFFICIENTLY WITH EVEN LESS OXYGEN.
SO IF YOU CAN MAKE MITOCHONDRIA,
THEY BECOME UNCOUPLED, YOU HAVE LESS MITOCHONDRIA PER CELL,
AND IT SETS THE STAGE FOR CHRONIC DISEASE.
SO WE SEE IN MOST ATHLETES,
PROFESSIONAL ATHLETES USE OUR NITRIC OXIDE PRODUCT TECHNOLOGY.
REBECCA: YEAH.
BECAUSE THEY NEED TO BE FUNCTIONING
ON AN EVEN HIGHER LEVEL,
PERFORMANCE-WISE,
WITH THEIR BODIES.
SO WHY IS THERE A NITRIC OXIDE DEFICIENCY IN OUR WORLD TODAY?
DR. BRYAN: IT'S BASICALLY EVERYTHING WE DO
ON A DAILY BASIS, FROM THE FOODS WE EAT
TO THE DRUG THERAPY WE TAKE TO THE ORAL HYGIENIC PRACTICES
THAT WE EMPLOY ALL AROUND US.
SO WE AND OTHERS HAVE DISCOVERED THAT
THERE'S BACTERIA THAT LIVE IN THE GRIPS OF THE TONGUE
AND THE MOUTH THAT ARE RESPONSIBLE
FOR THE PRODUCTION OF NITRIC OXIDE.
SO ANYTHING THAT DESTROYS THE MICROBIOME, SUCH AS --
REBECCA: OH, WOW.
SO IT'S CONNECTED TO THE MICROBIOME, AS WELL,
THE NITRIC OXIDE?
DR. BRYAN: ABSOLUTELY.
SO THERE ARE BACTERIA THAT ARE RESPIRE ON NITROGEN
AND NITRATE AND THEN THEY REDUCE NITRATE TO NITRITE.
WE SWALLOW IT, AND WHEN IT REACHES THE ENVIRONMENT
OF OUR STOMACH, IT PRODUCES NITRIC OXIDE GAS.
AS LONG AS THERE'S SUFFICIENT STOMACH ACID PRODUCTION.
SO ALL OF THIS IS DEPENDENT UPON GOOD ORAL HYGEINE
AND A GOOD ORAL MICROBIOME.
AND THEN WHEN YOU THINK ABOUT, OKAY,
WHAT'S DISRUPTING THIS?
FLUORIDE.
THERE'S FLUORIDE IN MOST TOOTHPASTE.
REBECCA: AND STILL MOST DENTISTS USE IT.
DR. BRYAN: AND FLUORIDE RINSES.
AND THERE'S, IN 73% OF THE MUNICIPALITIES IN THE U.S.,
THERE'S FLUORIDE IN THE DRINKING WATER.
IT'S NOT JUST THE DRINKING WATER,
IT'S THE WATER YOU'RE BATHING IN,
YOU'RE COOKING IN, YOU'RE DRINKING.
AND SO FLUORIDE IS AN ANTISEPTIC.
IT'S PUT IN THE WATER TO KILL THE BACTERIA IN THE PIPES.
SO IT KILLS THE BACTERIA IN OUR PIPES, RIGHT.
IN OUR GUT, IN OUR MOUTH.
THERE'S A MICROBIOME ON OUR SKIN,
IT'S KILLING THE GOOD BACTERIA ON THE SKIN,
CAUSING ACNE, FUNGAL OVERGROWTH, DERMATITIS.
SO WE HAVE TO SUPPORT THE MICROBIOME AND NOT DESTROY IT.
SO FLUORIDE IS A BAD ACTOR.
AND WE HAVE TO GET RID OF IT.
I THINK WE'RE ON THE RIGHT PATH TO GETTING RID OF FLOURIDE.
AND IT LOWERS IQ IN KIDS BY AS MUCH AS 7 POINTS.
REBECCA: YEAH.
THAT'S CRAZY.
DR. BRYAN: AND THEN THE OTHER THING IS ANTISEPTIC MOUTH WASH.
TWO OF OUT THREE AMERICANS WAKE UP EVERY MORNING
AND USE MOUTH WASH, KILLING THE ENTIRE MICROBIOME.
AND NOT COINCIDENTALLY TWO OUT OF THREE AMERICANS
HAVE AN UNSAFE ELEVATION IN BLOOD PRESSURE.
SO WE'VE DONE CONTROLLED STUDIES WHERE WE TAKE
PEOPLE WITH NORMAL BLOOD PRESSURE AND WE JUST GIVE THEM
MOUTH WASH FOR SEVEN DAYS
AND WE SEE THEIR BLOOD PRESSURE GO UP.
JUST BY KILLING THE MICROBIOME,
WE CAN SEE AN INCREASE IN BLOOD PRESSURE.
NOW, THINK ABOUT THE GLOBAL IMPACT OF THIS.
HIGH BLOOD PRESSURE'S THE NUMBER ONE DRIVER
FOR THE NUMBER ONE KILLER OF MEN AND WOMEN:
CARDIOVASCULAR DISEASE.
AND 50% OF THE PEOPLE WHO TAKE PRESCRIPTION MEDICATIONS
TO MANAGE YOUR BLOOD PRESSURE
DON'T RESPOND WITH BETTER BLOOD PRESSURE.
CALL THAT RESISTIVE HYPERTENSION.
REBECCA: REALLY?
DR. BRYAN: THEY'RE RESISTANT TO THERAPY.
REBECCA: [ GASPS ]
I DIDN'T KNOW THAT.
DR. BRYAN: YEAH.
REBECCA: I KNEW THAT THE NUMBER ONE PRESCRIPTION DRUG
THAT PEOPLE TAKE IS CONNECTED TO BLOOD PRESSURE,
THAT'S RIGHT, RIGHT?
DR. BRYAN: WELL,
THE NUMBER ONE IS A CHOLESTEROL-LOWERING MEDICATION.
BUT NOW, THESE DRUGS ARE RESISTANT --
THESE PEOPLE ARE RESISTANT TO DRUG THERAPY
BECAUSE IT'S THE WRONG TARGET.
THE DRUGS THAT ARE TREATED FOR HYPERTENSION
ARE USUALLY ACE INHIBITORS,
WHICH ARE AN INTERSENSORY CONVERTING ENZYME,
ARB'S, AN INTERSENSORY RECEPTOR BLOCKERS,
CALCIUM CHANNEL BLOCKERS,
OR DIURETICS TO MOBILIZE FLUID OR WORST CASE,
BETA BLOCKER TO PACE THE HEART.
BUT YET PEOPLE DON'T RESPOND WITH BETTER BLOOD PRESSURE.
BECAUSE WHAT WE'RE FINDING IS THEIR HYPERTENSION
IS A SYMPTOM OF ORAL DYSBIOSIS AND LACK OF NITRIC OXIDE.
REBECCA: WOW.
DR. BRYAN: SO NOW, YOU HAVE A CONVERSATION WITH A PATIENT
AND PHYSICIAN, AND GO, OKAY,
YOU'RE RESISTANT TO ACE INHIBITORS, ARB'S,
CALCIUM CHANNEL BLOCKERS.
DO YOU USE A FLUORIDE IN YOUR TOOTHPASTE?
YES.
DO YOU USE MOUTH WASH?
YES.
OKAY.
STOP USING MOUTH WASH.
GET RID OF FLUORIDE IN YOUR TOOTHPASTE.
COME BACK 30 DAYS LATER, AND LET'S CHECK YOUR BLOOD PRESSURE.
AND REMARKABLY, THEIR BLOOD PRESSURE COMES DOWN.
SO IF WE STOP KILLING THE NITRIC OXIDE-PRODUCING BACTERIA
IN THE MOUTH AND WE SUPPORT IT,
WE REPOPULATE AND RESTORE THESE FLORA,
THESE BACTERIA, THEN OUR BLOOD PRESSURE CAN BECOME NORMAL.
AND ON A GLOBAL SCALE, IF WE CAN MANAGE BLOOD PRESSURE,
BECAUSE EVERY 1 MILLIMETER OF MERCURY
OF INCREASE IN BLOOD PRESSURE INCREASES YOUR RISK
OF CARDIOVASCULAR DISEASE BY 1%.
SO IF YOU'VE GOT A BLOOD PRESSURE OF 140/90,
YOU HAVE A 20% GREATER RISK -- OR 20% GREATER RISK
OF DEVELOPING CARDIOVASCULAR DISEASE.
SO THIS IS THE TARGET.
THE MICROBIOME IS THE TARGET.
AND THAT'S WHAT WE'RE FOCUSED ON IN RESTORING THE PRODUCTION,
NATURAL PRODUCTION OF NITRIC OXIDE.
REBECCA: AND YOU'RE WORKING ON A MOUTH WASH;
AM I CORRECT?
DR. BRYAN: WE JUST LAUNCHED A TOOTH PASTE,
BECAUSE I'VE STRUGGLED FOR YEARS.
NUMBER ONE, THERE ARE SOME FLUORIDE-FREE TOOTHPASTES
OUT THERE THAT I'VE BEEN USING,
BUT THERE ARE OTHER THINGS IN THERE THAT I DIDN'T LIKE,
BUT IT'S THE BEST OUT THERE.
SO I THOUGHT, OKAY, NOW THAT WE UNDERSTAND
THE ECOLOGY OF THE ORAL MICROBIOME,
I'M GOING TO DEVELOP A TOOTHPASTE, NUMBER ONE,
THAT'S FREE OF FLUORIDE, BUT NUMBER TWO,
REMINERALIZES THE TEETH --
REBECCA: YES, BECAUSE THAT'S THE OTHER THING YOU NEED.
DR. BRYAN: AND THEN SUPPORTS THE HEALTHY MICROBIOME.
AND SO THAT WAS PROBABLY A FIVE-YEAR PROJECT.
WE LAUNCHED A TOOTHPASTE A COUPLE OF MONTHS AGO.
REBECCA: I'M SO EXCITED.
DR. BRYAN: IT'S INCREDIBLE.
WE'RE STARTING TO SEE PEOPLE'S BLOOD PRESSURE COME DOWN
JUST BY SWITCHING TO OUR TOOTHPASTE.
AND THEN WE'RE ALSO LAUNCHING
A MICROBIOME-SPECIFIC MOUTH RINSE.
SO AGAIN, ONE THAT WILL KILL THE PATHOGENIC BACTERIA,
BUT SUPPORTS THE NORMAL NON-PATHOGENIC COMMENSAL BACTERIA.
SO AGAIN, TARGETING THE MICROBIOME,
SUPPORTING THE MICROBIOME.
IT'LL BE A GAME-CHANGER.
REBECCA: Y'ALL, I'M SO EXCITED FOR THIS BECAUSE I LIKE --
I'M GOING TO LIKE GEEK OUT OVER ALL THIS STUFF,
AND THIS IS LIKE THE KIND OF PRODUCTS
THAT I'VE BEEN LOOKING FOR, SO I AM SO EXCITED BECAUSE,
YES, A LOT OF PEOPLE UNDERSTAND KIND OF ABOUT
HOW IMPORTANT THE MICROBIOME IN OUR GUT IS,
BUT PEOPLE DON'T UNDERSTAND THE MICROBIOME IN THE MOUTH
AND HOW --
DR. BRYAN: OR ON OUR SKIN.
PEOPLE THAT HAVE POOR SKIN HEALTH.
AND PEOPLE TAKING MULTIPLE BATHS A DAY WITH ANTISEPTIC SOAPS
AND RINSING OFF THE BACTERIA
AND IT'S CAUSING DYSBIOSIS.
AND THEY DEVELOP BODY ODOR,
THEN THESE ANTIPERSPIRANTS DEODORANTS,
WHICH CONTAIN ALUMINUM AND TOXINS,
AND IT'S JUST THIS VICIOUS CYCLE.
REBECCA: OH, NO!
THE ALUMINUM IS -- I KNEW THE ALUMINUM WAS BAD FOR YOUR BODY
BECAUSE IT'S A TOXIN,
BUT IT ALSO IS BAD FOR THE BACTERIA?
DR. BRYAN: FOR THE BACTERIA, YEAH.
REBECCA:
[ GASPS ]
OH, NO!
ARE YOU MAKING DEODORANT?
DR. BRYAN: WE'RE WORKING ON THAT.
BECAUSE HERE'S THE PROBLEM.
REBECCA: OH, THANK GOD, BECAUSE THAT'S ANOTHER ONE.
DR. BRYAN: SMELL OCCURS,
WHETHER IT'S BAD BREATH, BAD ARMPITS,
OR SMELLY POOP, IT'S ALL FROM THE BACTERIA.
IT'S DYSBIOSIS.
SO IF YOUR ARMPITS SMELL,
IT MEANS YOU'VE GOT A BACTERIAL PROBLEM.
YOU'VE GOT AN IMBALANCE IN DYSBIOSIS.
IF YOUR BREATH STINKS, YOU'VE GOT DYSBIOSIS.
SO WHAT WE TRIED TO DO, RATHER THAN KILLING EVERYTHING
AND THROWING AN ATOMIC BOMB IN THERE,
LET'S SELECTIVELY KILL THE ODOR CAUSING THE PATHOGENIC BACTERIA
AND LET'S SUPPORT THE NON-PATHOGENIC COMMENSALS.
I HAVEN'T WORN DEODORANT IN
MORE THAN 20 YEARS, BUT YET I DON'T HAVE BODY ODOR.
I DON'T PUT THOSE ON ME BECAUSE I SUPPORT MY MICROBIOME.
I DON'T DESTROY IT.
REBECCA: WHAT DO YOU DO FOR YOUR MICROBIOME?
DR. BRYAN: UM, WELL, TYPICALLY NUMBER ONE,
I DON'T USE ANY TOXINS.
SO I DON'T USE ANY LOTIONS OR
ANY ANTIDEPRESSANT OR DEODORANT, UM.
AND I HAVE A HOME FILTRATION SYSTEM.
SO I'M NOT MAKING MY BODY ANTISEPTIC WITH FLUORIDE
WHAT I BATHE IN OR DRINK OR COOK IN,
BUT I TAKE NITRIC OXIDE AND I TRY TO EAT
A GOOD CLEAN DIET.
AND I'M EXPOSED TO SUNLIGHT
AT LEAST 20 TO 30 MINUTES A DAY FULL,
FULL BODY EXPOSURE AND THAT HELPS KIND OF
REPOPULATE AND CREATE BALANCE IN THE MICROBIOME.
REBECCA: REALLY?
I DIDN'T KNOW I KNOW HOW IMPORTANT SUNLIGHT
EXPOSURE IS, BUT I DIDN'T KNOW ABOUT THE CONNECTION
TO YOUR MICROBIOME.
DR. BRYAN: OH, YEAH.
REBECCA: DO YOU TRY TO DO IT AT A CERTAIN TIME OF DAY?
DR. BRYAN: FOR SUNLIGHT IN THE MORNING.
REBECCA: THAT'S WHAT EVERYONE SAYS.
THEY SAY IT'S THE BEST SUNLIGHT.
DR. BRYAN: NO, IT IS.
IT COMPLETELY RESETS YOUR CIRCADIAN RHYTHM.
SO WHAT I DO WHEN I WAKE UP,
I WAKE UP, YOU KNOW.
USUALLY AN HOUR BEFORE THE SUN COMES UP.
I SIT IN A SAUNA FOR 30 MINUTES IN 170 DEGREES.
AND THERE,
I'M DOING MY PRAYERS.
I OPEN MY HALLOW APP.
AND I JUST I GIVE GRATITUDE, I PRAY
AND REALLY THAT'S HOW I START MY DAY WITH GRATITUDE
AND JUST I HAVE A --
EVERY DAY I WAKE UP I HAVE A PLAN.
AND THE PLAN IS NUMBER ONE,
HOW DO I BE BETTER THAN I WAS YESTERDAY?
AND THEN HOW DO I --
HOW AM I GOING TO EXECUTE THIS
STRATEGY HOUR BY HOUR?
AND THAT GETS MY MIND MENTALLY
PREPARED FOR THE DAY.
AND THEN AFTER 30 MINUTES OF SAUNA,
I'LL TYPICALLY A COUPLE DAYS A WEEK GO DO A COLD PLUNGE.
GET IN A NICE BATH FOR THREE MINUTES.
AND THEN I'LL GO SIT OUT IN MY FRONT YARD
AND WATCH THE SUN COME UP
AND GET THAT FIRST SUNLIGHT,
USUALLY 20 OR 30 MINUTES.
REBECCA: AND YOU LOOK INTO THE --
DR. BRYAN: LOOK INTO THE SUN.
REBECCA: BECAUSE THERE'S SOMETHING ABOUT THAT TOO.
DR. BRYAN: YEAH, IT RESETS YOUR, YOUR CIRCADIAN RHYTHM.
IT'S ACTIVATING A LOT OF PATHWAYS IN THE EYE THAT
GETS THE EYE READY AND RECEPTIVE FOR --
THE WORST THING YOU CAN
DO IS WEAR, WEAR SUNGLASSES AND I USED
TO WEAR SUNGLASSES ALL THE TIME.
REBECCA: ME TOO.
DR. BRYAN: AND IT AFFECTED MY SLEEP PATTERN.
I WAS A POOR SLEEPER AND YOU CAN'T HEAL
WITHOUT PROPER SLEEP.
REBECCA: THAT'S CRAZY.
AND THEN THE SCREENS AT NIGHT.
THAT'S THE OTHER THING THAT MESSES
WITH YOUR CIRCADIAN RHYTHM.
DR. BRYAN: YEAH, SO AT NIGHT WHEN THE SUN GOES DOWN,
I WEAR THE BLUE BLOCKER GLASSES.
REBECCA: I NEED TO GET SOME OF THOSE.
DR. BRYAN: TO KEEP THE ARTIFICAL LIGHT OFF.
REBECCA: BUT THEY'RE NOT ALL EQUAL, RIGHT?
SOME ARE BETTER THAN OTHERS.
DR. BRAYN: IT'S LIKE ANY PRODUCT OUT THERE.
YOU'VE GOT SOME REALLY GOOD
BRANDS THAT ACTUALLY DO STUFF AND
YOU'VE GOT THESE,
UM, WANNA BE COMPANIES WHO ARE JUST SELLING YOU
A BILL OF GOODS.
REBECCA: AND THERE'S OTHER NITRIC --
IS THERE OTHER NITRIC OXIDE PEOPLE?
DR. BRYAN: NOW LOOK THERE'S HUNDREDS OF COMPANIES OUT
THERE SELLING HUNDREDS OF SO-CALLED NITRIC OXIDE
PRODUCTS AND THAT'S MY GREATEST CHALLENGE...
REBECCA: YEAH.
DR. BRYAN: EVERY DAY WHEN I WAKE UP,
IT'S HOW DO WE DIFFERENTIATE WHAT WE DO
FROM ALL THESE OTHER WANNABES OUT THERE.
BECAUSE WHAT I'VE DONE IS SPENT 25 YEARS IN THE TRENCHES, IN
THE RESEARCH LAB, UNDERSTANDING THE BIOCHEMISTRY
AND ENTOMOLOGY TO WHERE I HAVE
AN UNDERSTANDING WHERE I CAN MAKE PRODUCTS.
ALL THESE OTHER COMPANIES OUT THERE
ARE KIND OF, YOU KNOW, FOLLOWING THE FAD?
REBECCA: YEAH.
DR. BRYAN: THEY'RE CREATING A MARKET FOR IT
AND THEY WANT TO PROFIT OFF THOSE --
THAT GROWING MARKET.
SO THERE'S HUNDREDS OF PRODUCTS OUT THERE,
BUT THE PROBLEM IS MOST OF THEM DON'T WORK.
AND I TEST THESE PRODUCTS.
I HAVE A NITRIC OXIDE ANALYZER.
I CAN TELL YOU IF IT'S WORKING OR NOT
AND NONE OF THEM WORK.
REBECCA: YEAH.
DR. BRYAN: THEY GIVE YOUR BODY PRECURSORS AND SUBSTRATES
AND HOPING YOUR BODY CAN CONVERT IT,
BUT THE REASON PEOPLE ARE NITRIC OXIDE DEFICIENT IS
THE ENDOGENOUS SYSTEMS FOR UTILIZING THAT IS BROKEN.
SO YOU JUST MAKE EXPENSIVE URINE.
REBECCA: YOU'RE JUST PEEING IT OUT.
DR. BRYAN: YOU'RE JUST PEEING IT OUT, YEAH.
AND SO WHAT I TRY TO DO IS NUMBER ONE,
EDUCATE, INFORM ON THE SCIENCE OF NITRIC OXIDE.
REBECCA: YEAH.
DR. BRYAN: HOPEFULLY BUILD TRUST
BECAUSE I'VE BEEN THERE.
I UNDERSTAND THE SCIENCE
AND THAT WHAT I DO WE VALIDATE OUR PRODUCTS.
WE SHOW YOU HOW THEY WORK.
YOU CAN SEE THEM WORKING RIGHT BEFORE YOUR EYES.
AND, YOU KNOW, OTHER COMPANIES, COMPETITIVE
COMPANIES DON'T LIKE THAT.
AND WHEN I SHOW THE TRUTH
AND SHOW THEIR PRODUCTS DON'T WORK,
I GET SUED OR THEY COMPLAIN TO, UH,
ORGANIZERS AT MEDICAL MEETINGS THAT I CAN'T TEST
THEIR PRODUCTS ANYMORE.
BECAUSE IT, IT REVEALS
THE TRUTH THAT THEIR PRODUCTS ARE, ARE NOT EFFECTIVE
AND REALLY FRAUDULENT.
IT'S -- AT THE END OF THE DAY,
IT'S FRAUD.
REBECCA: WELL, I'M GLAD WE'RE OUT HERE
SPREADING THE TRUTH.
ANOTHER THING THAT YOU
SAID THAT TAKES OUT NITRIC OXIDE, DEPLETES US IS SUGAR.
YOU TALK ABOUT THAT.
DR. BRYAN: SUGAR, SUGAR IS THE POISON.
IT'S THE TOXIN.
IT'S THE ENEMY.
REBECCA: BUT EVERY ONE SAYS, YOU'RE LIKE --
I'VE HEARD THIS FROM SO MANY GUESTS AND I'M LIKE I
DON'T KNOW WHO INVENTED THIS AND PUT IT IN ALL OF
OUR STUFF BECAUSE IT'S IN EVERYTHING.
DR. BRYAN: WELL, IT'S ADDICTIVE.
I MEAN, IT'S MORE --
SOME PEOPLE SAY IT'S MORE
ADDICTIVE THAN COCAINE.
OR SO IT GETS PEOPLE --
AGAIN, IT'S A GREAT FINANCIAL MODEL BECAUSE IT GETS
PEOPLE HOOKED ON A PRODUCT.
REBECCA: AND DEPLETED.
DR. BRYAN: AND DEPLETED.
AND SO IF YOU'RE, IF YOU'RE ON A HIGH SUGAR DIET,
YOU'RE GOING TO BE DEPENDENT UPON
PHARMACEUTICALS AND NOW BIG, BIG AG, BIG PHARMA,
BIG FOOD IS, YOU KNOW,
IT'S A COLLUSION TO SHARE IN THE PROFITS.
REBECCA: I KNOW AND IT MAKES FOOD MORE ADDICTIVE.
SO YOU EAT MORE.
DR. BRYAN: IT MAKES FOOD MORE ADDICTIVE.
REBECCA: YOU GET MORE SICK.
ONE OF THE BIGGEST THINGS I SAW,
SO I'VE ACTUALLY CUT DOWN SUGAR
AS MUCH AS POSSIBLE.
I REALLY LIKE, IF ANYTHING HAS CANE SUGAR,
WHICH Y'ALL
IT'S LIKE IN EVERYTHING.
LIKE I DON'T THINK PEOPLE REALIZE --
DR. BRYAN: IT'S HARD TO AVOID.
REBECCA: LIKE PEOPLE THINK IT'S JUST LIKE SWEETS.
IT'S IN LIKE DRINKS.
IT'S IN SAUCES.
IT'S IN,
I MEAN, ALMOST ANY KIND OF PROCESSED FOOD.
DR. BRYAN: SALAD DRESSINGS.
REBECCA: YEAH.
IT HAS SUGAR.
AND IF YOU GO OUT TO EAT,
IT'S BECAUSE IT'S A CHEAP WAY TO MAKE FOOD MORE,
YOU KNOW, ADDICTIVE AND LIKE FOR PEOPLE TO EAT.
BUT ALL THAT BEING SAID,
I MAJORLY CUT DOWN ON IT.
AND ONE OF THE FIRST THINGS
I SAW IS HOW MUCH BETTER
MY IMMUNE SYSTEM WAS, AND I WASN'T GETTING --
I DON'T GET SICK.
I WAS GETTING SICK ALL THE TIME,
BECAUSE I HAVE LITTLE KIDS.
AND I WAS LIKE I CAN'T BE SICK.
THAT WAS, THAT'S ONE OF MY BIGGEST MOTIVATORS
TO STAY AWAY FROM IT.
AND IT MAKES ME, IT CAUSES INFLAMMATION.
SO IT MAKES ME FEEL BAD.
IF I START TO EAT SUGAR,
I NOTICE ALMOST IN LIKE A COUPLE DAYS,
I WILL FEEL BAD BECAUSE MY BODY'S LIKE FREAKING OUT.
IT'S MAKING ALL THIS INFLAMMATION.
DR. BRYAN: WELL, WE CAN EXPLAIN THAT MECHANISTIC
BECAUSE HERE'S WHAT SUGAR DOES.
IF YOU EAT SUGAR OR EAT FOODS THAT
ARE CONVERTED TO SUGAR IN THE BODY,
IT LEADS TO AN INCREASE IN BLOOD SUGAR
OR FASTING GLUCOSE.
SO GLUCOSE,
AS THE NAME IMPLIES, IS GLUE.
IT'S STICKY, RIGHT?
IF YOU SPILL A SODA WATER ON THE
TABLE TOP AND COME BACK THE NEXT DAY,
IT'S STICKY.
REBECCA: YEAH.
DR. BRYAN: WELL, IT CREATES STICKINESS
INSIDE THE BODY,
INSIDE THE LINING OF THE BLOOD VESSELS WHERE BLOOD
CELLS STARTS STICKING TOGETHER.
YOU LOSE THE ABILITY TO DELIVER OXYGEN BECAUSE IT
STICKS TO HEMOGLOBIN AND LOCKS IT IN A
CONFORMATIONAL STATE WHERE IT CAN'T DELIVER OXYGEN.
AND THEN IT STICKS TO THE ENZYME THAT MAKES NITRIC OXIDE.
YOU BECOME NITRIC OXIDE DEFICIENT.
AND THEN IF YOU EAT A LOT OF SUGAR,
IT CHANGES THE PH IN YOUR MOUTH.
IT DROPS THE PH.
YOUR SALIVARY PH,
YOUR SALIVA BECOMES VERY ACIDIC.
AND NOW THAT CREATES AN ENVIRONMENT FOR A
COMPLETELY DIFFERENT TYPE OF BACTERIA TO POPULATE.
AND IT'S THE CARIES-CAUSING BACTERIA.
IT'S THE GINGIVAL PLAQUE, THE BACTERIA THAT CAUSES
GUM DISEASE, GINGIVITIS.
SO YOU HAVE TO GET RID OF SUGAR,
THEN THE OTHER BIG THING IS MOUTH BREATHERS.
YOU KNOW, THE MOUTH IS NOT FOR BREATHING,
IT'S FOR SPEAKING.
SO PEOPLE WHO SLEEP WITH
THEIR MOUTH OPEN AGAIN,
YOU'RE FULLY OXYGENATING THAT ORAL CAVITY.
REBECCA: ALL NIGHT LONG.
DR. BRYAN: ALL NIGHT LONG.
YOU'RE CHANGING THE PH OF YOUR SALIVA.
YOU'VE GOT COMPLETE DYSBIOSIS AND YOUR BREATH
SMELLS LIKE A GUT WAGON WHEN YOU WAKE UP IN THE
MORNING BECAUSE OF DYSBIOSIS.
REBECCA: AND YOU KNOW WHAT'S AWFUL ABOUT THAT AND I'LL JUST
SAY THIS REALLY QUICK AND WE'LL GET BACK ON NITRIC OXIDE,
BUT IT KIND OF GOES BACK TO HOW IT ALL WORKS TOGETHER.
PEOPLE USUALLY DID NOT HAVE AN ISSUE WITH MOUTH
BREATHING, BUT BECAUSE WESTON PRICE.
HE STUDIED THIS, THE DENTIST.
DR. BRYAN: YEAH.
REBECCA: THAT IF HE WENT TO --
WHEN THE INDUSTRIAL REVOLUTION,
BECAUSE HE'S NO LONGER ALIVE,
PEOPLE WERE HAVING
A LOT OF TEETH ISSUES.
HE WENT TO INDIGENOUS COMMUNITIES THAT ATE A
WHOLE FOODS DIET OF FOODS RICH IN MEAT AND WHOLE FOODS.
THEY WEREN'T EATING PROCESSED
AND THEY HAD NO ISSUES.
AND WHEN YOU WOULD LOOK AT THEM,
IT'S BECAUSE THEY'RE JAW IS FULLY DEVELOPED.
THERE'S SPACE FOR THEIR TEETH.
WELL, WHAT IS A HUGE INDUSTRY,
EVERYONE NEEDS, ME INCLUDING, NEEDED BRACES.
DR. BRYAN: YEAH.
REBECCA: BECAUSE THERE WASN'T ROOM IN MY MOUTH.
SO A LOT OF PEOPLE ARE MOUTH BREATHING AND ALSO
TONGUE-TIED, LIP TIES, BUT I WON'T GET INTO THAT.
I'M JUST PASSIONATE ABOUT THIS.
UM, A LOT OF PEOPLE ARE MOUTH BREATHING BECAUSE
THERE IS NOT ENOUGH SPACE.
AND SO THAT'S A WHOLE OTHER TOPIC.
BUT PEOPLE CAN MOUTH TAPE AT NIGHT
AND YOU CAN WORK WITH AN AIRWAY SPECIALIST.
DR. BRYAN: I ALWAYS RECOMMEND
AN AIRWAY SPECIALIST BEFORE YOU GO TO
TAPE IN YOUR MOUTH.
BECAUSE IF YOU'VE GOT
AN OBSTRUCTIVE AIRWAY...
REBECCA: OH, YEAH, YOU'LL CHOKE YOURSELF.
DR. BRYAN: LAST THING YOU WANT TO DO IS TAPE
YOUR MOUTH, RIGHT?
YOUR ONLY SOURCE OF OXYGEN.
REBECCA: I FORGOT ABOUT THAT.
DR. BRYAN: DON'T EXPERIMENT WITH THAT.
REBECCA: NO, YOU'RE RIGHT.
SO YOU NEED TO GO TO AN AIRWAY SPECIALIST
AND THERE IS STUFF THAT YOU CAN DO AS AN ADULT.
UM, OKAY.
SO THAT'S VERY, THAT'S LIKE
A LIFE-CHANGING THING, Y'ALL.
AND IF YOU HAVE LITTLE KIDS,
YOU CAN REALLY CHANGE.
DR. BRYAN: NO, I THINK AS A KID,
IF YOUR KID IS SLEEPING WITH THEIR MOUTH OPEN,
YOU MUST GO SEE A PEDIATRIC AIRWAY
SPECIALIST BECAUSE THEY HAVE A PROBLEM.
AND IT DEVELOPS BEHAVIORAL ISSUES,
IT DEVELOPS A LOT OF PSYCHOLOGICAL ISSUES.
YOU HAVE TO GET THEM FULLY OXYGENATED.
REBECCA: YES, BECAUSE THEY'RE NOT BREATHING.
DR. BRYAN: THEY'RE NOT BREATHING.
THEY'RE NOT BEING FULLY OXYGENATED.
REBECCA: ADHD, AND SO THERE'S A LOT OF KIDS
THAT ARE BEING MISDIAGNOSED BECAUSE --
DR. BRYAN: IT'S AN AIRWAY PROBLEM.
REBECCA: YEAH.
DR. BRYAN: AND THEY WANT TO MEDICATE THESE KIDS.
REBECCA: AND THEY WANT TO TAKE YOUR ADENOIDS AND YOUR TONSILS
OUT BECAUSE THEY EXPAND BECAUSE YOU'RE BREATHING
WITH YOUR MOUTH.
SO THERE'S, YOU KNOW, THIS IS WHAT'S SO FASCINATING.
DR. BRYAN: AGAIN, IT'S NOT
ADDRESSING THE ROOT CAUSE OF THE PROBLEM.
REBECCA: AND IT'S A HUGE PROBLEM IN TODAY'S SOCIETY.
BUT YEAH, SUGAR AND YOU, YOU KNOW,
IT'S SO INTERESTING.
I HAD DR. AMEN ON WHO IS A BRAIN DOCTOR.
DR. BRYAN: YEAH.
REBECCA: AND HE LITERALLY SAID OUT OF ALL
THE HEALTH STUFF,
HE WAS LIKE I'M PAYING ATTENTION
TO MY MOUTH HEALTH.
HE SAID THAT.
DR. BRYAN: WELL, HE DOES THE PET SCANS OF THE BRAIN
AND HE CAN SEE
THE EFFECTS OF SUGAR IN DIFFERENT -- AND ALCOHOL
AND COCAINE.
REBECCA: IN YOUR MOUTH.
DR. BRYAN: AND YEAH, DYSBIOSIS IN YOUR MOUTH.
REBECCA: YEAH.
HE SAYS THAT BECAUSE OF THE WAY IT'S CONNECTED.
HE SAID THERE'S --
HE'S LIKE THE EFFECT --
HE SAID THAT HE SAW IN HIS PATIENTS THE CONNECTION
BETWEEN MOUTH HEALTH AND BRAIN HEALTH.
AND SO HE SAYS --
AND HE ALSO WEARS A GLUCOSE MONITOR.
SO AFTER YOU TALK --
I HEARD YOU TALKING ABOUT THAT,
I WAS LIKE I KIND OF WANT TO GET ONE BECAUSE YOU
WON'T REALLY --
THAT'S WHAT HE SAID, HE'S LIKE YOU WON'T REALLY
KNOW WHAT SPIKING YOU.
DR. BRYAN: YOU GOT TO KNOW HOW YOUR BODY RESPONDS.
REBECCA: EXACTLY.
IF YOU, BECAUSE A LOT OF DISEASE ALSO IS
COMING FROM INSULIN RESISTANCE.
MOST PEOPLE ARE
INSULIN RESISTANT AND THEY DON'T KNOW IT.
BECAUSE PEOPLE JUST THINK OH, IF YOU HAVE DIABETES,
BUT IT CAN COME --
EVEN PEOPLE WHO ARE NOT OVERWEIGHT,
EVEN THOUGH MOST PEOPLE IN AMERICA ARE
OVERWEIGHT NOW WHICH IS KIND OF CRAZY.
THAT'S ANOTHER EPIDEMIC.
DR. BRYAN: YEAH.
REBECCA: UM, BUT YOU CAN HAVE INSULIN RESISTANCE
AND NOT EVEN KNOW IT.
DR. BRYAN: WELL, WHAT WE FOUND,
WE PUBLISHED THIS IN 2011.
INSULIN RESISTANCE IS A SYMPTOM OF NITRIC OXIDE DEFICIENCY.
SO IF THE CELL CAN'T MAKE NITRIC OXIDE,
INSULIN CAN'T DO ITS JOB
AND SIGNAL TO BRING GLUCOSE INTO THE
CELL AND CLEAR IT FROM THE CIRCULATION.
REBECCA: REALLY?
DR. BRYAN: SO THE BROKEN SYSTEM
INSULIN RESISTANCE --
YOU BECOME RESISTANT TO INSULIN BECAUSE THE CELL
CAN'T MAKE NITRIC OXIDE.
REBECCA: THAT IS HUGE.
DR. BRYAN: SO WHEN THE CELL MAKES NITRIC OXIDE,
IT ACTIVATES
A PROTEIN CALLED GLUT4,
WHICH TELLS IT TO GO TO
THE MEMBRANE, BRING GLUCOSE, CLEAR IT
FROM THE CIRCULATION.
AND THAT'S HOW WE CLEAR GLUCOSE AFTER A MEAL.
AND THAT'S WHAT KEEPS YOU FROM GETTING THE GLUCOSE SPIKE.
AND AS LONG AS INSULIN IS - YOUR BODY, YOUR CELLS ARE
SENSITIVE TO IT, THEN INSULIN SPIKES,
BUT IT GOES DOWN.
GLUCOSE SPIKES, BUT IT COMES DOWN,
AND THAT'S HOW WE REGULATE BLOOD SUGAR.
BUT IF YOU CAN'T MAKE NITRIC OXIDE,
YOU CAN'T GET GLUCOSE INTO THE CELL,
THEN IT TELLS YOUR PANCREAS,
HEY, I NEED MORE INSULIN.
PUT, PUSH MORE INSULIN, PUSH MORE INSULIN.
THEN YOU GET Hyperinsulinemia,
HYPERGLYCEMIA AND THAT'S
THE CASCADE OF INFLAMMATION THAT LEADS TO
DIABETIC NEUROPATHY, MACULAR DEGENERATION, HEART
ATTACK, STROKE, POOR HEALING WOUNDS
THAT EXPLAINS EVERYTHING ABOUT DIABETES.
REBECCA: BECAUSE DIABETES AFFECTS BLOOD FLOW RIGHT.
AND THAT'S WHY PEOPLE LIKE THEY CAN
HAVE PROBLEMS WITH THEIR --
DR. BRYAN: WELL, NEUROPATHY, THE SMALL FIBERS,
WHETHER IT'S, YOU KNOW,
SMALL FIBER DISEASE OR LARGE FIBER DISEASE,
THOSE, THOSE NERVES HAVE TO HAVE BLOOD VESSELS SUPPLY, RIGHT?
AND SO WHEN YOU'RE DIABETIC, YOU HAVE
MICROVASCULAR DYSFUNCTION.
YOU CAN'T MAKE NITRIC OXIDE.
SO THOSE NERVE FIBERS ARE NO LONGER GETTING PERFUSED.
THERE'S NO SODIUM.
THERE'S NO POTASSIUM, YOU CAN'T ELICIT ON ACTION
POTENTIAL IN YOUR DEVELOPING NEUROPATHY.
REBECCA: SO WHAT'S SO INTERESTING ABOUT THIS
CONVERSATION IS BASICALLY FINDING OUT THAT NITRIC
OXIDE HELPS THE BODY, THE CELLS IN
A LOT OF DIFFERENT WAYS.
DR. BRYAN: NOW I TELL PEOPLE IT'S FOUNDATIONAL,
IT'S AN ESSENTIAL MOLECULE.
IT'S NOT, LOOK,
IT'S NOT A PANACEA.
IT'S NOT A END-ALL, BE-ALL CURE-ALL,
BUT HERE'S WHAT WE DO KNOW
THAT YOUR BODY CANNOT AND WILL NOT HEAL OR BECOME
OPTIMIZED WITHOUT ADEQUATE NITRIC OXIDE.
THERE MAY BE OTHER THINGS THAT ARE CONTRIBUTING
TO YOUR DISEASE.
BUT AT THE END OF THE DAY,
IF YOU'VE GOT CHRONIC DISEASE,
YOU HAVE NITRIC OXIDE DEFICIENCY.
LET'S FIRST RESTORE THE PRODUCTION OF NITRIC OXIDE,
THEN LET'S FOCUS ON
WHAT NUTRIENTS ARE YOU DEFICIENT IN?
WHAT TOXINS ARE YOU EXPOSED TO?
FIX THAT AND THEN YOUR BODY HEALS ITSELF.
REBECCA: THAT'S SO GOOD.
UM, WHAT I LOVE ABOUT
WHAT YOU'VE DEVELOPED TOO IS THAT,
IT'S -- YOU'VE HAD PATIENTS WHO ARE
ON VARIOUS PRESCRIPTION DRUGS
TAKE THIS AND IT'S HAD NO NEGATIVE.
BECAUSE A LOT OF TIMES,
THERE'S THAT RISK OF IF TAKE THIS,
IT'S GOING TO INTERFERE WITH MY OTHER...
DR. BRYAN: YEAH.
REBECCA: PRESCRIPTIONS SO IT SHOWS
REALLY HOW SAFE IT IS.
CAN YOU SPEAK TO THAT?
DR. BRYAN: YEAH.
LOOK, WE HAVE A LONG HISTORY OF SAFETY
BECAUSE NUMBER ONE,
I KNOW HOW MUCH NITRIC OXIDE THE HUMAN BODY MAKES
AND I WANT TO GIVE THAT BACK.
SO I'M NEVER GIVING
MORE THAN WHAT THE BODY IS USUALLY EXPOSED TO.
BUT THEN WHAT WE DIDN'T KNOW,
WHAT WE DID KNOW
PRIOR TO FOUR YEARS AGO WAS WHAT ABOUT PEOPLE THAT
ARE ON DIFFERENT MEDICATIONS, POLYPHARMACY.
AND DURING OUR COVID DRUG STUDY,
WE HAD OUR NITRIC OXIDE RELEASING LOZENGE AND IN A
PHASE THREE CLINICAL TRIAL FOR COVID AND FOUND THAT
IN SOME OF THESE PATIENTS WERE
ON 20 DIFFERENT MEDICATIONS.
WHEN WE DID A CENSUS OF WHAT
MEDICATIONS THEY WERE TAKING,
I MEAN, PEOPLE ARE OVERMEDICATED.
SO THE POINT IS THAT EVEN WHEN WE GAVE OUR LOZENGE
ON TOP OF THEIR 20 DIFFERENT MEDICATIONS,
THERE WAS NO INTERACTIONS WITH ANY OF THE MEDICATIONS.
THERE WAS NO UNSAFE DROP IN BLOOD PRESSURE.
IN FACT, THERE WAS NO SAFETY SIGNAL WHATSOEVER.
SO WE KNOW THAT OUR DRUG TECHNOLOGY AND OUR PRODUCT
DELIVERY IS EXTREMELY SAFE THAT DOESN'T INTERACT WITH
MEDICATIONS AND LEAD TO AN UNSAFE DROP IN BLOOD PRESSURE.
SO THAT'S NUMBER ONE, FIRST DO NO HARM.
I MEAN, SAFETY IS THE UTMOST NUMBER ONE PRIORITY.
AND THEN NUMBER TWO, IS IT EFFECTIVE?
WELL, WE KNOW AND WE'VE HAD CONVERSATIONS
AND MANY PHYSICIANS
USE THIS IN THEIR PATIENTS AND START HAVING FOR THE
FIRST TIME A CONVERSATION
of, OKAY, WE'VE HAD YOU ON THESE BLOOD PRESSURE MEDICINES
FOR 20 YEARS.
NOW IT SEEMS LIKE YOUR BLOOD
PRESSURE IS BETTER MANAGED.
LET'S BACK OFF THOSE AND LET'S SEE
IF WE CAN START WEANING
YOU OFF OF PRESCRIPTION MEDICATION.
AND LO AND BEHOLD, AGAIN,
WE FOCUS ON THE TARGET.
WE FOCUS ON THE MICROBIOME.
WE ELIMINATE TOXINS.
WE REPLETE NUTRIENTS
and THERE'S NO NEED FOR PRESCRIPTION MEDICATION.
rebecca: THAT'S AMAZING.
THAT IS SO AMAZING.
HAVE YOU NOTICED,
WELL, I DON'T EVEN KNOW BECAUSE I KNOW
WITH PREGNANT PEOPLE,
THEY DON'T EVER -- WOMEN,
THEY DON'T EVER WANT TO DO ANYTHING,.
BUT I KNOW THAT PREECLAMPSIA IS A MASSIVE
ISSUE IN PREGNANCY AND THAT'S A BLOOD --
DR. BRYAN: THAT'S A BLOOD
PRESSURE PROBLEM.
YES, SO MY WIFE TOOK OUR PRODUCT DURING
ALL THE PREGNANCIES.
UH, EARLY FORMS OF IT.
AND THEN EARLY ON, WE DID A STUDY AT MEMORIAL HERMANN
OR -- BEEN TAUGHT IN HIGH-RISK PREGNANCIES
AND SPECIFICALLY PREECLAMPSIA.
AND THE PROBLEM WITH PREECLAMPSIA
IS YOU DEVELOP REALLY HIGH BLOOD PRESSURE.
rebecca: yeah, AND THEN IT causes
A BUNCH OF PROBLEMS.
DR. BRYAN: well, THE ONLY TREATMENT IS PREMATURE DELIVERY.
REBECCA: YEAH, WHICH IS AWFUL.
DR. BRYAN: BECAUSE IF YOU TREAT WITH BLOOD PRESSURE MEDICINES,
A LOT OF TIMES IT'LL CAUSE INCREASE IN
INTRACRANIAL PRESSURES AND THE WOMEN WILL
GO INTO SEIZURES.
SO YOU HAVE TO BE VERY CAREFUL ON HOW YOU TREAT THEM.
REBECCA: YEAH.
DR. BRYAN: SO WE TOOK,
I THINK IT WAS 4 TO 5 PREECLAMPTIC PATIENTS
THAT WERE ADMITTED.
WE DOSED THEM WITH OUR LOZENGE.
IT NORMALIZED THEIR BLOOD PRESSURE.
IT DIDN'T CAUSE AN
INCREASE IN INTRACRANIAL PRESSURES.
WE DID AN ULTRASOUND OF THE FETUS,
AND IT WAS VERY WELL-TOLERATED.
AND IN SOME OF THOSE PATIENTS,
WE COULD EXTEND GESTATION FOR 7 OR 10 DAYS.
AND THINK ABOUT THAT.
REBECCA: THAT'S HUGE.
DR. BRYAN: I MEAN, FROM A, FROM A DEVELOPING BABY
AND A PREMATURE BABY
THAT'S UNDERDEVELOPED, THE RISK...
REBECCA: YES.
DR. BRYAN: YOU KNOW, OF EVEN INFANT MORTALITY.
YOU KNOW, EVEN MOTHER MORTALITY
IS STILL EXTREMELY HIGH.
SO IF WE CAN EXTEND GESTATION,
MANAGE THEIR BLOOD PRESSURE,
THEN BOTH MOTHER AND BABY ARE GOING TO BE
BETTER FOR IT.
AND IT WAS AN AMAZING FINDING.
WE NEVER FOLLOWED
UP ON IT BECAUSE THAT'S A, AGAIN, A DRUG STUDY
THAT'S VERY EXPENSIVE AND LONG-TERM, BUT --
REBECCA: YEAH.
DR. BRYAN: I MEAN, PRACTICALLY IT WORKS,
AND WE'RE, WE'RE I STILL
TELL PEOPLE IF YOU HAVE PREECLAMPSIA
OR GESTATIONAL DIABETES,
THE LOZENGE IS COMPLETELY SAFE.
REBECCA: OH, YEAH, I FORGOT ABOUT
GESTATIONAL DIABETES.
YEAH, PREECLAMPSIA,
I MEAN, JUST BECAUSE, YOU KNOW,
I'VE HAD MY OWN BABIES.
I'M ALWAYS TALKING TO WOMEN.
A LOT OF WOMEN HAVE THAT
AND IT CAUSES A LOT OF COMPLICATIONS.
AND I'VE EVEN KNOWN PEOPLE THAT HAD COMPLICATIONS WITH IT
AFTER GIVING BIRTH.
I MEAN, WHERE THEIR BLOOD PRESSURE
AND, YOU KNOW, THEY HAD TO BE ADMITTED TO A HOSPITAL
RIGHT AFTER GIVING BIRTH.
UM, AND SO IF SOMETHING COULD HELP MITIGATE THAT,
THAT WOULD BE,
THAT'S, THIS IS AMAZING.
I LOVE THAT.
DR. BRYAN: YEAH,
WE'VE DONE A LOT OF WORK WITH PREGNANCY AND
EVEN NURSING, YOU KNOW, ANALYZING BREAST MILK AND
BABIES ARE GETTING A REALLY RICH
SOURCE OF NITRIC OXIDE THROUGH BREAST MILK
THAT'S NOT PRESENT IN FORMULA.
REBECCA: THAT'S SO COOL.
DR. BRYAN: SO WE 2020, 2011 PAPER WE PUBLISHED,
WE ARGUED THAT THE HEALTH BENEFITS CONFERRED THROUGH
BREASTFEEDING IS PARTLY DEPENDENT UPON NITRIC OXIDE.
IT'S NOT JUST THE PASSAGE OF THE IMMUNOGLOBULINS.
BUT, YOU KNOW, BABIES WHO ARE BREASTFED FOR AT LEAST
SIX MONTHS HAVE LOWER INCIDENTS OF DIABETES,
HIGH BLOOD PRESSURE, AUTOIMMUNE DISEASE
LATER IN LIFE.
AND WE ARGUE THAT IT'S PARTIALLY A NITRIC OXIDE PROBLEM.
AND EVEN WHEN MY LAST SON WAS BORN,
I COLLECTED THE, UH, THE EMBRYONIC FLUID DURING DELIVERY.
WE WERE IN THERE,
AND WHEN THE WATER BROKE,
I GOTTA HAVE SOME OF THAT,
AND WE TOOK IT TO THE LAB
AND WE ANALYZED IT.
BUT THESE BABIES DURING NINE
MONTHS OF GESTATION ARE BATHED IN A REALLY NITRIC
OXIDE RICH ENVIRONMENT.
REBECCA: REALLY!
THAT IS SO INTERESTING.
DR. BRYAN: AND THEN WHEN YOU
HAVE VAGINALLY-DELIVERED BABIES,
YOU'RE GETTING INOCULATED
RIGHT THROUGH THE VAGINAL CANAL.
WHERE CESAREAN DELIVERY,
THEY LACK THAT INOCULATION.
AND WE KNOW THAT VAGINAL
DELIVERED BABIES HAVE BETTER IMMUNE SYSTEMS
THAN CESAREAN.
SO WE ARGUED AGAIN THAT THERE'S A, THERE'S A
CRITICAL ROLE FOR INOCULATION OF THOSE GOOD BACTERIA,
THAT IF WE CAN RESTORE THAT AND
RECAPITULATE THAT EVEN THROUGH CESAREAN DELIVERIES,
THEN THE BABY WILL BE HEALTHIER
FOR IT AND BREASTFEEDING.
REBECCA: THEY'RE JUST STARTING TO, I JUST SAW WHERE THEY,
THEY'RE DOING STUDIES
NOW ON CESAREAN BABIES.
AND, I MEAN, IN AMERICA,
WE HAVE A HIGH,
I MEAN, WAY TOO HIGH OF A NUMBER OF WOMEN GETTING C-SECTIONS.
AND WHAT BREAKS MY HEART IS I KNOW WOMEN
AND I'VE SEEN WOMEN STORIES WHERE THEY DON'T
KNOW THE RISKS INVOLVED.
I MEAN, IT'S ONE THING TO GO INTO BIRTH
AND NEED A C-SECTION.
IT'S ANOTHER THING TO JUST CHOOSE TO GET A C-SECTION.
AND DOCTORS AREN'T TELLING THEM ALL THE THINGS THEIR
BABIES ARE MISSING OUT ON.
AND NOW THEY'RE DOING RESEARCH.
AND, I MEAN, THAT PASSAGE OF THE BABY THROUGH THEY, YOU KNOW.
I THINK ONE,
THEY CALL IT LIKE THE CANAL OF LIFE.
AND IT'S BECAUSE THAT BACTERIA IS SETTING UP THEIR
MICROBIOME FOR THE REST OF THEIR LIFE.
AND THEN THAT BREASTFEEDING ALSO
CONTRIBUTES TO THAT MICROBIOME FOR
THE REST OF THEIR LIFE.
AND THEY DID A STUDY ON BABIES AND A LOT
OF THEM WERE DEFICIENT IN,
I CAN'T SAY THE BACTERIA NAME.
IT'S LIKE B INFANTIS.
DR. BRYAN: Bifidobacterium.
REBECCA: YES.
IT'S A VERY ESSENTIAL BACTERIA.
AND THEN ON TOP
OF THAT, I MEAN, OVERPRESCRIPTION OF ANTIBIOTICS.
SO TO BE MINDFUL OF THE MICROBIOME AND SEE HOW
THIS CAN HELP PLAY A ROLE IN HELPING SUPPORT
THAT IS MASSIVE.
DR. BRYAN: YEAH, WE THINK IT'S A GAME CHANGER.
I MEAN, WE LIVE IN THIS,
YOU KNOW, GERMOPHOBIC SOCIETY WHERE, YOU KNOW,
I STILL GET ON A PLANE EVERY WEEK AND THEY'RE
GIVING ME THE ANTIBACTERIAL, ANTISEPTIC
CLOTHS AND TRYING TO -- AND I STILL SIT NEXT TO PEOPLE
WHO ARE WIPING EVERYTHING DOWN.
AND USE, BATHE TWO OR
THREE TIMES A DAY WITH ANTIBACTERIAL SOAPS,
ANTIBACTERIAL MOUTHWASH AND FLUORIDE TOOTHPASTE.
AND THEY'RE SICK, THEY'RE UNHEALTHY.
REBECCA: YEAH.
DR. BRYAN: AND WE HAVE TO, YOU KNOW,
I LIKE TO USE NATURE AS AN EXAMPLE.
AND I HAVE A RANCH
JUST THREE HOURS SOUTH OF HERE AND HAVE HORSES
AND DOGS AND SO...
I NOTICED IF YOU BATHE YOUR HORSE
OR BATHE YOUR DOG,
WHAT DO THEY DO?
THEY GO ROLL IN THE DIRT.
REBECCA: YEAH
DR. BRYAN: RIGHT?
SO THEY'RE REINOCULATED.
THEY'RE A LOT SMARTER THAN WE ARE BECAUSE THEY DON'T WANT,
THEY KNOW THEY HAVE TO REINOCULATE.
AND THOSE AMMONIA-OXIDIZING BACTERIA
THAT ARE FOUND IN THE SOIL,
WHEN WE SWEAT, WE SECRETE AMMONIA.
THERE'S AMMONIA-OXIDIZING BACTERIA
THAT PRODUCES NITRIC OXIDE.
AND SO IT'S A, IT'S AN ECOLOGY OF
NITRIC-OXIDE PRODUCING SYSTEMS BASED ON THE BACTERIA THAT
LIVE IN OUR BODY AND ON OUR BODY.
AND SO KIDS NEED
TO GET OUT THERE AND EAT SOME DIRT, ROLL AROUND IN
SOME DIRT, AND NOT HAVE THIS GERMOPHOBIC MINDSET
OF MANY PARENTS.
REBECCA: YEAH, YEAH.
AND I THINK EVEN WITH COVID, PEOPLE GOT EVEN
WORSE ABOUT ALL OF THAT STUFF.
DR. BRYAN: EVERYTHING WE WERE DOING
DURING COVID WAS COUNTERINTUITIVE.
REBECCA: YEAH.
DR. BRYAN: YOU KNOW, ANTIBIOTICS FOR A VIRAL
INFECTION, BY THE WAY.
UM, ANTISEPTIC MOUTHWASH, USING N-ACIDS.
EVERYTHING WE WERE DOING.
SOCIAL --
REBECCA: HAND SANITIZER.
THEY WERE DOING THAT AT MY CHURCH.
THEY WERE FORCING THE KIDS AND KNOWING WHAT I KNOW,
I WAS LIKE NO!
DR. BRYAN: YEAH, AND WEARING MASKS AND BREATHING
IN YOUR OWN CARBON DIOXIDE
AND HYPOXIC.
AND I MEAN, LOOKING BACK,
IT WAS -- IT'S CRIMINAL.
THERE'S NO OTHER WORD FOR IT.
IT'S CRIMINAL.
REBECCA: AND YOU WERE DURING COVID, TREATING PATIENTS
WITH NITRIC OXIDE AND YOU WERE SEEING AN IMPROVEMENT,
BUT THEN YOU HAD PUSHBACK.
CAN YOU TALK ABOUT?
DR. BRYAN: YEAH,
WE HAD A DRUG AS AN EARLY THERAPEUTIC.
BECAUSE THE CHALLENGE EARLY ON DURING COVID WAS
HOW DO WE DEVELOP A SAFE AND EFFECTIVE EARLY
TREATMENT TO KEEP PEOPLE OUT OF THE HOSPITAL?
BECAUSE EARLY ON, THE ER'S IN THE HOSPITALS
WERE OVERRUN WITH, WITH PEOPLE AND THEY COULDN'T
MANAGE AND PEOPLE WERE DYING IN THE STREETS
ALL OVER THE WORLD.
SO WE DEVELOPED A --
WE WERE FAST-TRACKED FOR THROUGH
FDA AND WE HAD A DRUG CALLED NITROVERE.
UM, THAT WE WERE TREATING FOR COVID PATIENTS AND WE
WOULD TRY TO FIND THEM WITHIN 72 HOURS OF
DIAGNOSIS OR ONSET OF SYMPTOMS AND TREAT THEM
WITH NITRIC OXIDE.
BECAUSE WHAT WE'VE REALIZED EARLY ON
WAS THAT PEOPLE THAT WERE GETTING SICK AND DYING
FROM COVID WERE THE PEOPLE WHO COULD NOT MAKE NITRIC OXIDE.
THE ELDERLY, THE HYPERTENSIVE, THE DIABETICS
PREVIOUS HEART ATTACK, AFRICAN-AMERICANS, FOR EXAMPLE.
SO WE THOUGHT IF WE CAN GIVE THEM NITRIC OXIDE
EARLY ON, WE CAN PREVENT THE VIRUS FROM REPLICATING.
WE CAN MITIGATE THE VASCULAR INFLAMMATION THAT
WE WERE SEEING WITH COVID.
AND WE COULD, WE COULD PROTECT AGAINST
THE LOSS OF BLOOD OXYGEN SATURATION,
THE HYPOXIA, THAT ALLOWED FOR
THE ADMISSION INTO HOSPITALS
IN THE INTENSIVE CARE UNIT.
SO WITHIN THE FIRST HUNDRED PATIENTS,
WE'D ALREADY SEEN A STATISTICALLY
SIGNIFICANT DIFFERENCE BETWEEN THE GROUP.
WE ASSUMED THAT THE PEOPLE WERE GETTING BETTER ON THE
ACTIVE DRUG AND NOT THE PLACEBO.
AND SO WE PETITIONED THE FDA TO GIVE US EMERGENCY USE
AUTHORIZATION BECAUSE IT WAS, NUMBER ONE, SAFE.
BUT NUMBER TWO, IT SEEMED TO BE MAKING PATIENTS
BETTER AND KEEPING THEM OUT OF THE HOSPITAL.
AND THIS WAS AFTER THE BIDEN ADMINISTRATION HAD TAKEN
OVER THE WHITE HOUSE AND THE FDA ADVISED US TO
CONTINUE THE CLINICAL TRIAL
TO THE END AND THEN
OBVIOUSLY COVID CHANGED AND PEOPLE WEREN'T GETTING
SICK AND GOING TO THE HOSPITAL.
SO WE HAD TO ABORT THE CLINICAL TRIAL.
BUT LOOKING BACK,
THEY WERE NEVER GOING TO APPROVE OUR DRUG BECAUSE
HAD THEY HAD HAD A SAFE AND EFFECTIVE DRUG FOR
THERAPY OR FOR COVID ON THE MARKET,
THEY COULD HAVE NEVER MANDATED THE VACCINES.
AND AT THAT POINT, AT THAT POINT IN TIME,
THEY WERE HELL-BENT ON PUSHING FOR VACCINE MANDATES,
GETTING EVERYBODY IN THE WORLD VACCINATED.
AND IF WE HAD A SAFE AND EFFECTIVE NITRIC OXIDE
DRUG ON THE MARKET,
THEN THEY COULD HAVE NEVER MANDATED THE VACCINES.
REBECCA: SO HOW DID THEY SHUT YOU DOWN?
DR. BRYAN: TOLD US TO COMPLETE THE CLINICAL TRIAL.
KEEP ENROLLING PATIENTS.
AND WE HAD, YOU KNOW,
HAD TO ENROLL 840 PATIENTS TO HIT OUR PRIMARY
ENDPOINT BASED ON THE POWER ANALYSIS.
BUT, YOU KNOW, LATER DURING COVID --
REBECCA: THEY STRUNG YOU ALONG
TO WHERE IT WAS TOO HARD.
DR. BRYAN: BECAUSE PEOPLE WEREN'T GETTING SICK
AND GOING TO
THE HOSPITAL ANYMORE, RIGHT?
IT WAS A THREE-YEAR OLD DISEASE.
THE FEAR, IT KIND OF WANED.
PEOPLE WERE REALIZING
IT WAS PROBABLY A CONTRIVED,
UH, MANMADE PHENOMENON.
SO THERE WAS LESS FEAR AND LESS PEOPLE
GOING TO THE HOSPITAL.
AND IF YOU DIDN'T COMPLETE OUR STUDY,
IF YOU WEREN'T HOSPITALIZED
OR ADMITTED TO THE ICU OR YOU DIED, UM, SO
WE HAD TO ABORT THE STUDY.
REBECCA: IT'S VERY EXPENSIVE TOO.
DR. BRYAN: IT'S VERY EXPENSIVE
TO CONDUCT LARGE-SCALE DRUG STUDIES.
REBECCA: YEAH, THAT'S CRAZY.
DR. BRYAN: SO WE STOPPED AND WE TABLED IT
FOR THE NEXT
RESPIRATORY VIRUS OUTBREAK.
BUT WE KNOW, WE'VE GOT A SAFE DRUG PRODUCT.
AND WE JUST KEEP IT ON THE SHELF TILL THE NEXT ONE
AND THEN WE'LL WE'LL DEPLOY IT AGAIN.
REBECCA: HOW DOES IT HELP FIGHT A VIRUS?
DR. BRYAN: WELL, WE'VE KNOWN FOR PROBABLY 20
YEARS NOW THAT NITRIC OXIDE
ACTUALLY PREVENTS A VIRUS FROM
REPLICATING AND THIS WAS IN...
REBECCA: REALLY?
DR. BRYAN: SARS-COV-1 CORONAVIRUS,
NOT SARS-COV-2 WHICH WAS CORONA.
BUT DATA AT THE, I BELIEVE, IT
WAS SWEDEN OR SWITZERLAND,
SHOWED IN 2005 THAT NITRIC OXIDE PREVENTS
THE VIRUS FROM REPLICATING.
SO IN TERMS OF RESPIRATORY,
THE NORMAL IMMUNE RESPONSE TO VIRUSES.
WHEN WE'RE EXPOSED TO A VIRUS,
WHETHER IT'S RSV, INFLUENZA,
CORONAVIRUS, OUR BODY RECOGNIZES THAT.
AND IT GOES,
I'M BEING ATTACKED.
I GOT TO MOBILIZE AN IMMUNE RESPONSE.
THE IMMUNE CELLS GO THERE,
THE SIDE OF ATTACHMENT
GENERATE A LOT OF NITRIC OXIDE FOR A
SHORT PERIOD OF TIME AND PREVENT
THE VIRUS FROM REPLICATING.
SO THINK ABOUT IT IN THOSE AT-RISK,
THAT THOSE WHO CAN'T
MAKE NITRIC OXIDE, NUMBER ONE,
THEY'VE GOT AN UPREGULATION OF ACE2 RECEPTOR
WHERE THE CORONAVIRUS,
THE SPIKE PROTEIN BINDS TO.
SO THERE'S MORE ATTACHMENT SITES FOR THE VIRUS TO
ENTER AND TO PENETRATE THE CELL.
SO THAT'S NITRIC OXIDE DEFICIENCY.
THEY'RE MORE SUSCEPTIBLE TO VIRAL
INFECTIONS BECAUSE OF THAT UPREGULATION OF CERTAIN
RECEPTORS THAT VIRUSES BIND TO.
SO IN PEOPLE WHO
CAN'T MAKE NITRIC OXIDE,
THEY GOT MORE TARGET, MORE
ENTRIES OF ENTRY OR MORE PORTS OF ENTRY INTO THE
CELL BY THE VIRUS.
AND THEN YOU CAN'T MOBILIZE AN IMMUNE RESPONSE.
AND SO BY THAT TIME, THE VIRUS HAS TAKEN
OVER IN THE CELL.
IT'S RAPIDLY REPLICATING.
IT'S PROPAGATING THROUGHOUT THE BODY,
RELEASING THE SPIKE PROTEIN, CAUSING VASCULAR
INFLAMMATION, CAUSING PLATELETS TO AGGREGATE,
MICROCLOTS, BREAK THEM DOWN, ELEVATION AND D-DIMERS.
THERE'S YOUR LONG-COVID PATIENT AND THERE'S YOUR
SYSTEMIC DISEASE FROM A RESPIRATORY INFECTION.
REBECCA: HAS THIS HELPED PEOPLE WITH LONG COVID?
DR. BRYAN: ABSOLUTELY.
REBECCA: OH, THAT'S HUGE.
DR. BRYAN: BECAUSE THE PROBLEM IS,
LOOK, YOU'VE GOT
THE VASCULAR INFLAMMATION.
SEVERAL OF MY PATENTS ARE
ON A METHOD OF REDUCING VASCULAR INFLAMMATION.
SO NITRIC OXIDE LOWERS THE INFLAMMATION,
DOWNREGULATES THE ACE2 RECEPTORS.
SO THERE'S LESS TARGET FOR THE SPIKE PROTEIN TO BIND TO,
PREVENTS PLATELETS FROM BECOMing ACTIVATED,
PREVENTS PLOT FORMATION OR CLOT FORMATION.
REBECCA: THAT'S --
DR. BRYAN: AND THAT'S HUGE.
I MEAN, PEOPLE DIED FROM HEART ATTACK, STROKE,
FROM THESE MASSIVE CLOTS BASED ON AUTOPSY REPORTS.
REBECCA: YEP, THERE WAS A HUGE UPTAKE
IN PEOPLE GETTING HEART PROBLEMS.
I MEAN, TONS OF PEOPLE.
IS THERE ANY -- HAVE YOU SEEN
ANY IMPROVEMENT WITH CANCER WITH NITRIC OXIDE?
DR. BRYAN: YOU KNOW, THERE'S TWO CAMPS OUT
THERE IN CANCER.
CANCER IS A PRETTY COMPLEX DISEASE TO ME.
CANCER IS A METABOLIC DISEASE.
CANCER ONLY GROWS
IN A LOW OXYGEN, LOW PH, LOW VOLTAGE ENVIRONMENT.
AND THAT'S CALLED -- WE CALL THAT THE WARBURG EFFECT.
YOU KNOW, OTTO WARBURG WON A NOBEL PRIZE...
REBECCA: YEAH.
DR. BRYAN: I THINK THE 1930S FOR THE DISCOVERY
THAT CANCER IS A METABOLIC DISEASE.
AEROBIC FERMENTATION, UNCOUPLED
ELECTRON TRANSPORT CHAIN, AND THAT CREATES AN
ENVIRONMENT FOR CANCER CELLS TO RAPIDLY
PROLIFERATE AND GROW AND FORM A PRIMARY TUMOR.
SO THE THOUGHT PROCESS IS IN
A PRIMARY TUMOR ENVIRONMENT,
YOU NEVER WANT TO GIVE
A WHAT'S CALLED A PROANGIOGENIC FACTOR.
MEANING A MOLECULE THAT CAN INDUCE
VASCULARGENESIS and ANGIOGENESIS.
BECAUSE IT WAS THOUGHT THAT YOU COULD GROW NEW BLOOD VESSELS TO
THAT HYPOXIC TUMOR, AN INDUCED METASTATIC DISEASE.
THAT'S ONE CAMP.
MY CAMP IS THAT BECAUSE A PRIMARY TUMOR IS LOW
OXYGEN, LOW PH, LOW VOLTAGE,
NITRIC OXIDE IS THE
ANTIDOTE TO THAT, RIGHT?
WHAT DOES NITRIC OXIDE DO?
DILATES THE BLOOD VESSELS,
OXYGENATES THE TISSUE, RECOUPLES
THE ELECTRON TRANSPORT CHAIN.
REBECCA: YEAH.
DR. BRYAN: IT'S A FREE RADICAL,
SO IT DONATES AN ELECTRON.
IT INCREASES THE VOLTAGE
IN THAT ENVIRONMENT.
SO EVERYTHING THat NITRIC
OXIDE IS AND DOES IS ANTI-CANCER.
REBECCA: WOW.
DR. BRYAN: BUT YOU HAVE TO ADDRESS
WHY THAT PRIMARY TUMOR GREW
IN THE FIRST PLACE.
THERE'S A WHOLE OTHER DISCUSSION...
REBECCA: YEAH.
DR. BRYAN: ON THAT, BUT TREATING THE CANCER
IN AN OXYGENATED
AND HYPOXIC PRIMARY TUMOR,
I THINK IS THE BEST MEDICINE.
REBECCA: THAT'S AMAZING.
WELL, THIS, WELL,
I'M TAKING THIS PRODUCT.
THIS HAS BEEN SUCH AN INCREDIBLE CONVERSATION.
THANK YOU SO MUCH FOR YOUR WORK AND YOUR DEDICATION.
THANK YOU FOR NOT GIVING UP WHEN THINGS WERE
DIFFICULT AND KEEP GOING AND KEEP MAKING PRODUCTS.
AND COME BACK AND WE CAN TALK ABOUT MORE THINGS.
DR. BRYAN: YEAH, THANK YOU, REBECCA.
IT'S BEEN A GREAT PLEASURE.
REBECCA: IT'S BEEN AWESOME.
THANK YOU SO MUCH, DOCTOR.
DR. BRYAN: THANK YOU.