WEBVTT 00:00:09.400 --> 00:00:10.133 REBECCA LAMB WEISS: DR. NATHAN BRYAN, 00:00:10.233 --> 00:00:11.200 WELCOME TO THE SHOW. 00:00:11.300 --> 00:00:11.833 DR. NATHAN BRYAN: THANK YOU SO MUCH. 00:00:11.933 --> 00:00:12.766 GREAT TO BE WITH YOU. 00:00:12.866 --> 00:00:13.933 REBECCA: I AM SO EXCITED. 00:00:14.033 --> 00:00:16.666 I REMEMBER I WAS ABLE TO BE ON AN INTERVIEW WITH YOU 00:00:16.766 --> 00:00:17.899 ON ANOTHER SHOW, AND, MAN, 00:00:17.999 --> 00:00:20.400 MY LITTLE WHEELS WERE TURNING BECAUSE THIS, 00:00:20.500 --> 00:00:22.266 WHAT YOU'RE DOING IS SO IMPORTANT. 00:00:22.366 --> 00:00:23.199 DR. BRYAN: THANK YOU. 00:00:23.299 --> 00:00:23.866 I THINK SO. 00:00:23.966 --> 00:00:24.566 [ LAUGHING ] 00:00:24.666 --> 00:00:25.633 REBECCA: I THINK SO, TOO. 00:00:25.733 --> 00:00:27.600 AND ONE OF THE THINGS I WAS THINKING ABOUT, 00:00:27.700 --> 00:00:30.400 I WENT TO GOOD OLD ORAL ROBERTS UNIVERSITY, 00:00:30.500 --> 00:00:32.766 AND THEY HAD THIS THING WHERE THEY WERE LIKE 00:00:32.866 --> 00:00:36.733 WHOLE PERSON EDUCATION, AND IT WAS LIKE BODY, SOUL, AND SPIRIT. 00:00:36.833 --> 00:00:39.300 AS BELIEVERS, WE SHOULD TAKE CARE OF ALL THREE. 00:00:39.400 --> 00:00:41.467 BUT ONE OF THE THINGS I WAS THINKING ABOUT IS CHRISTIANS, 00:00:41.567 --> 00:00:42.833 A LOT OF TIMES, 00:00:42.933 --> 00:00:45.866 WILL FOCUS ON THE HEALTH OF OUR SOULS AND THE HEALTH SPIRITUALLY 00:00:45.966 --> 00:00:49.033 BUT WILL REALLY NEGLECT THE HEALTH OF OUR BODIES. 00:00:49.133 --> 00:00:51.967 AND IT REALLY CAN ACTUALLY CAUSE DAMAGE IN THE BODY OF CHRIST. 00:00:52.067 --> 00:00:54.366 AND PEOPLE LEAVE US SOONER THAN THEY NEED TO. 00:00:54.466 --> 00:00:57.033 SO WE REALLY NEED TO BE STEWARDING OUR BODIES. 00:00:57.133 --> 00:00:57.833 DR. BRYAN: WE'RE A TEMPLE, 00:00:57.933 --> 00:00:59.166 AND WE'VE GOT TO TAKE CARE OF IT. 00:00:59.266 --> 00:01:01.966 WE HAVE TO -- OUR HEALTH IS OUR GREATEST ASSET. 00:01:02.066 --> 00:01:05.000 WE CAN'T ENJOY THE HARVEST AND THE FRUITS OF OUR LABOR 00:01:05.100 --> 00:01:06.567 IF WE DON'T HAVE GOOD HEALTH. 00:01:06.667 --> 00:01:09.133 REBECCA: AND THERE REALLY IS AN ATTACK ON OUR HEALTH 00:01:09.233 --> 00:01:11.833 IN OUR WORLD TODAY. 00:01:11.933 --> 00:01:14.733 DR. BRYAN: AND IT'S BEEN GOING ON FOR DECADES. 00:01:14.833 --> 00:01:18.266 AND I THINK CERTAINLY THE WAY THAT THE SO-CALLED EXPERTS 00:01:18.366 --> 00:01:21.766 GUIDE US ON NUTRITION AND DRUG THERAPY 00:01:21.866 --> 00:01:24.100 AND THE FOOD THAT WE'RE PRODUCING AND EATING 00:01:24.200 --> 00:01:27.366 IS NOT FOR THE BENEFIT OF HUMAN HEALTH. 00:01:27.466 --> 00:01:28.700 REBECCA: NO. 00:01:28.800 --> 00:01:33.600 AND I'VE BEEN ON MY OWN PERSONAL HEALTH JOURNEY FOR YEARS NOW. 00:01:33.700 --> 00:01:35.933 I THINK MAYBE SEVEN YEARS. 00:01:36.033 --> 00:01:38.866 AND I USED TO HAVE A LOT OF FEAR, 00:01:38.966 --> 00:01:40.200 AND I ALWAYS TRY TO TELL PEOPLE, 00:01:40.300 --> 00:01:41.266 YOU CAN'T LIVE YOUR LIFE OUT OF FEAR. 00:01:41.366 --> 00:01:44.300 THAT WILL DO MORE DAMAGE TO YOUR HEALTH. 00:01:44.400 --> 00:01:46.500 BUT ONE OF THE THINGS I FELT LIKE THE LORD SHOWED ME 00:01:46.600 --> 00:01:49.966 IS HE HAS DESIGNED OUR BODIES IN SUCH AN AMAZING WAY, 00:01:50.066 --> 00:01:53.133 AND HE HAS DESIGNED OUR BODIES THAT THEY CAN HEAL. 00:01:53.233 --> 00:01:54.533 THEY CAN HEAL THEMSELVES. 00:01:54.633 --> 00:01:57.467 WE JUST NEED TO SUPPORT THE BODY IN THAT PROCESS. 00:01:57.567 --> 00:01:58.833 DR. BRYAN: YEAH. 00:01:58.933 --> 00:02:00.700 I THINK WHAT I'VE LEARNED IN 25 YEARS IN ACADEMIA AND MEDICINE 00:02:00.800 --> 00:02:02.400 IS THAT PEOPLE GET SICK FOR TWO REASONS 00:02:02.500 --> 00:02:04.366 AND TWO REASONS ONLY: THEIR BODY'S MISSING 00:02:04.466 --> 00:02:06.700 SOMETHING THAT IT NEEDS OR IT'S EXPOSED TO SOMETHING 00:02:06.800 --> 00:02:08.933 THAT IT DOESN'T NEED IN THE FORM OF A TOXIN. 00:02:09.033 --> 00:02:11.233 SO IF WE CAN REPLETE MISSING NUTRIENTS 00:02:11.333 --> 00:02:14.933 AND WE CAN RID THE BODY OF TOXINS OR EXPOSURE OF TOXINS, 00:02:15.033 --> 00:02:16.700 THEN THE BODY HEALS ITSELF. 00:02:16.800 --> 00:02:18.167 DOCTORS DON'T HEAL PATIENTS. 00:02:18.267 --> 00:02:19.900 MEDICINE DOESN'T HEAL PATIENTS. 00:02:20.000 --> 00:02:21.999 THE HUMAN BODY HEALS ITSELF. 00:02:22.099 --> 00:02:24.066 WE'VE JUST GOT TO GET OUT OF THE WAY, RIGHT. 00:02:24.166 --> 00:02:28.433 AND FOR ME, SPENDING 30 YEARS OR MORE NOW IN SCIENCE 00:02:28.533 --> 00:02:30.033 AND PHYSIOLOGY AND TRYING TO UNDERSTAND 00:02:30.133 --> 00:02:34.200 HOW THE HUMAN BODY WORKS, I THINK A LOT OF THE DISCOVERIES 00:02:34.300 --> 00:02:36.433 I MADE EARLY ON WERE BECAUSE I MADE 00:02:36.533 --> 00:02:40.167 A CONSCIOUS EFFORT TO HAVE A CONVERSATION WITH OUR CREATOR. 00:02:40.267 --> 00:02:42.400 HOW CAN WE KNOW HOW THE BODY WORKS 00:02:42.500 --> 00:02:44.233 IF WE DON'T HAVE A RELATIONSHIP WITH THE CREATOR? 00:02:44.333 --> 00:02:46.467 REBECCA: AND I THINK THERE'S SUCH WISDOM IN THAT, 00:02:46.567 --> 00:02:49.267 AND I THINK THAT I WANT TO TALK ABOUT THAT, 00:02:49.367 --> 00:02:53.299 BECAUSE WHATEVER YOUR BELIEF IS AND WHATEVER YOUR WORLDVIEW 00:02:53.399 --> 00:02:54.699 AND YOUR MORAL COMPASS, 00:02:54.799 --> 00:02:57.033 THAT'S GOING TO AFFECT YOUR WORK. 00:02:57.133 --> 00:02:59.999 AND SO THE PEOPLE WHAT WE WANT IN THE FIELD OF SCIENCE 00:03:00.099 --> 00:03:03.267 AND MEDICINE ARE PEOPLE WHO HAVE A RELATIONSHIP WITH GOD 00:03:03.367 --> 00:03:04.966 AND UNDERSTAND THAT WE ARE CREATED 00:03:05.066 --> 00:03:06.899 AND HAVE A MORAL COMPASS BECAUSE SCIENCE, 00:03:06.999 --> 00:03:10.400 APPLIED THE WRONG WAY, CAN DO SO MUCH DAMAGE. 00:03:10.500 --> 00:03:12.100 DR. BRYAN: YEAH, I THINK WE'VE LIVED THROUGH THAT RIGHT NOW. 00:03:12.200 --> 00:03:13.066 REBECCA: YEAH. 00:03:13.166 --> 00:03:14.200 WE'VE SEEN SOME OF THE FRUITS OF THAT. 00:03:14.300 --> 00:03:17.533 SO TELL OUR AUDIENCE A LITTLE BIT OF YOUR STORY. 00:03:17.633 --> 00:03:19.900 DR. BRYAN: I'M A SMALL TOWN TEXAS BOY. 00:03:20.000 --> 00:03:22.233 I GREW UP IN A VERY RURAL, SMALL COMMUNITY 00:03:22.333 --> 00:03:23.700 JUST OUTSIDE OF AUSTIN. 00:03:23.800 --> 00:03:26.500 CAME FROM A DIVORCED HOME. 00:03:26.600 --> 00:03:30.266 MY PARENTS SEPARATED AND DIVORCED WHEN I WAS YOUNG, 00:03:30.366 --> 00:03:31.567 4 OR 5 YEARS OLD. 00:03:31.667 --> 00:03:33.066 AND THEN WHEN I WAS I GUESS 10, 00:03:33.166 --> 00:03:35.500 MY DAD SUFFERED A VERY SERIOUS CAR ACCIDENT 00:03:35.600 --> 00:03:37.233 THAT LEFT HIM PARALYZED FROM THE WAIST DOWN, 00:03:37.333 --> 00:03:40.833 AND MY BROTHER AND I WERE LIVING WITH MY DAD AT THAT TIME. 00:03:40.933 --> 00:03:43.833 AND HE WAS SELF-EMPLOYED, SO NO INSURANCE. 00:03:43.933 --> 00:03:47.467 FORTUNATELY, HE SURVIVED, BUT IT LEFT HIM PARALYZED 00:03:47.567 --> 00:03:49.166 FROM THE WAIST DOWN AND UNABLE TO WORK. 00:03:49.266 --> 00:03:52.733 SO AT 10 AND 11 YEARS OLD, MY BROTHER AND I HAD TO GO TO WORK 00:03:52.833 --> 00:03:56.267 TO PAY THE BILLS AND SUPPORT THE FAMILY 00:03:56.367 --> 00:03:58.299 WHILE DAD WAS IN THE HOSPITAL AND REHAB. 00:03:58.399 --> 00:04:01.766 AND SO WE DEVELOPED A STRONG SENSE OF INDEPENDENCE 00:04:01.866 --> 00:04:05.899 WITH THIS ATTITUDE OF DO WHATEVER IT TAKES. 00:04:05.999 --> 00:04:09.066 IT'S NEXT MAN UP. 00:04:09.166 --> 00:04:12.033 AND SO THEN I SAW THE MEDICAL SYSTEM FAIL MY DAD. 00:04:12.133 --> 00:04:15.433 JUST POOR HEALTH, POOR MEDICAL CARE, 00:04:15.533 --> 00:04:17.666 NON-HEALING WOUNDS, ULCERS, 00:04:17.766 --> 00:04:20.266 UNCONTROLLED DIABETES, HYPERTENSION. 00:04:20.366 --> 00:04:21.499 REBECCA: OH, MY GOODNESS. 00:04:21.599 --> 00:04:23.499 DR. BRYAN: AND SO WHEN I WAS IN HIGH SCHOOL, 00:04:23.599 --> 00:04:27.033 MY DAD RECOVERED AND HE WENT TO WORK AT A DIFFERENT CITY, 00:04:27.133 --> 00:04:28.199 AND MY BROTHER AND I DIDN'T WANT TO MOVE, 00:04:28.299 --> 00:04:31.167 SO WE GOT OUR OWN APARTMENT AND FINISHED HIGH SCHOOL. 00:04:31.267 --> 00:04:33.633 MY BROTHER GRADUATED, THEN I SPENT THE LAST TWO YEARS 00:04:33.733 --> 00:04:35.999 OF HIGH SCHOOL LIVING IN MY OWN APARTMENT. 00:04:36.099 --> 00:04:37.967 AND HAD TWO JOBS WORKING AFTER HIGH SCHOOL 00:04:38.067 --> 00:04:41.800 AND WAS PRETTY INDEPENDENT FROM THE TIME I WAS 16 YEARS OLD. 00:04:41.900 --> 00:04:44.167 REBECCA: THAT IS IMPRESSIVE. 00:04:44.267 --> 00:04:48.566 DR. BRYAN: BUT I WAS BLESSED WITH A GIFT, 00:04:48.666 --> 00:04:50.100 IF I WRITE SOMETHING, I SEE SOMETHING, 00:04:50.200 --> 00:04:51.067 I REMEMBER IT. 00:04:51.167 --> 00:04:52.533 SO I DID VERY WELL IN SCHOOL. 00:04:52.633 --> 00:04:55.433 I MADE GOOD GRADES AND GRADUATED AT THE TOP OF MY CLASS, 00:04:55.533 --> 00:04:57.533 AND THEN I WENT TO THE UNIVERSITY OF TEXAS AT AUSTIN. 00:04:57.633 --> 00:05:00.899 AND AS A SMALL NAIVE COUNTRY KID, 00:05:00.999 --> 00:05:03.133 ALL MY COUNSELORS SAID, YOU SHOULD BE AN ENGINEER. 00:05:03.233 --> 00:05:04.166 I'M LIKE, OKAY, WHATEVER. 00:05:04.266 --> 00:05:06.267 SO I ENROLLED IN ENGINEERING AT UT. 00:05:06.367 --> 00:05:07.433 AND THEN AFTER THE FIRST SEMESTER, 00:05:07.533 --> 00:05:09.299 I GO TO MY COUNSELOR AND I GO, WHAT DO ENGINEERS DO? 00:05:09.399 --> 00:05:12.066 WELL, THEY BUILD ROADS AND BRIDGES AND STRUCTURES. 00:05:12.166 --> 00:05:13.933 AND I GO, BUT THAT'S NOT WHAT I WANT TO DO. 00:05:14.033 --> 00:05:16.299 SO I ENTERED THE BIOCHEMISTRY PROGRAM 00:05:16.399 --> 00:05:18.266 IN THE COLLEGE OF NATURAL SCIENCE 00:05:18.366 --> 00:05:20.533 AND PURSUED A DEGREE IN BIOCHEMISTRY. 00:05:20.633 --> 00:05:23.900 REBECCA: WHAT TOOK YOU THERE? 00:05:24.000 --> 00:05:25.167 DR. BRYAN: REALLY JUST, AGAIN, 00:05:25.267 --> 00:05:26.733 I THINK MY DAD WAS MY INSPIRATION, 00:05:26.833 --> 00:05:29.766 TRYING TO UNDERSTAND HOW THE HUMAN BODY WORKS. 00:05:29.866 --> 00:05:32.067 I TOOK PHYSIOLOGY COURSES AND FELL IN LOVE WITH 00:05:32.167 --> 00:05:39.899 THE SCIENCE AND BIOLOGY AND BIOCHEMISTRY OF HUMAN SYSTEMS. 00:05:39.999 --> 00:05:41.400 AND THEN ONCE I HAD A DEGREE IN BIOCHEMISTRY, 00:05:41.500 --> 00:05:45.233 I THOUGHT I WOULD ACHIEVE MY GOALS AND TRIED TO FIND A JOB. 00:05:45.333 --> 00:05:45.933 THERE WERE NO JOBS. 00:05:46.033 --> 00:05:47.467 [ LAUGHING ] 00:05:47.567 --> 00:05:51.833 AND SO I ENROLLED AT LSU SCHOOL OF MEDICINE AND GOT A PH.D. 00:05:51.933 --> 00:05:53.400 IN MOLECULAR AND CELLULAR PHYSIOLOGY, 00:05:53.500 --> 00:05:55.067 AND THAT WAS WHEN I WAS INTRODUCED TO THIS WHOLE SCIENCE 00:05:55.167 --> 00:05:57.166 OF NITRIC OXIDE. 00:05:57.266 --> 00:05:58.700 REBECCA: SO YOU STUDIED, 00:05:58.800 --> 00:06:02.700 IN LAYMAN'S TERMS, BASICALLY HOW OUR CELLS WORK? 00:06:02.800 --> 00:06:03.533 DR. BRYAN: THAT'S EXACTLY RIGHT. 00:06:03.633 --> 00:06:05.267 AND I THINK I WOULD ADVOCATE, 00:06:05.367 --> 00:06:06.700 IF I COULD ADVOCATE AND CHANGE ANYTHING, 00:06:06.800 --> 00:06:09.366 IF YOU'RE GOING TO GO AND BE A PHYSICIAN, 00:06:09.466 --> 00:06:12.000 I THINK YOU HAVE TO HAVE A STRONG BACKGROUND 00:06:12.100 --> 00:06:13.967 IN BIOCHEMISTRY, RIGHT. 00:06:14.067 --> 00:06:17.500 HOW DO PROTEINS AND ENZYMES WORK TO FILL 00:06:17.600 --> 00:06:20.533 THE ENERGY OF THE CELL ON THE BODY? 00:06:20.633 --> 00:06:23.100 AND THEN PHYSIOLOGY IS AN ALL-ENCOMPASSING FIELD 00:06:23.200 --> 00:06:26.133 WHERE IT UNDERSTANDS HOW DOES GOING FROM 00:06:26.233 --> 00:06:30.500 THE SUBCELLULAR ORGANELLE-TYPE MODEL TO CELLULAR BIOLOGY 00:06:30.600 --> 00:06:33.199 TO ORGAN SYSTEMS TO HUMAN PHYSIOLOGY, 00:06:33.299 --> 00:06:34.266 HOW DOES ALL THAT INTEGRATE 00:06:34.366 --> 00:06:36.300 AND HOW DO THEY TIE INTO ONE ANOTHER? 00:06:36.400 --> 00:06:38.433 BECAUSE I THINK ONCE YOU HAVE A FIRM UNDERSTANDING OF THAT, 00:06:38.533 --> 00:06:40.067 THEN YOU CAN START TO INTERROGATE 00:06:40.167 --> 00:06:43.433 SYSTEMS THAT FAIL WHEN PEOPLE GET SICK. 00:06:43.533 --> 00:06:44.833 RIGHT. 00:06:44.933 --> 00:06:46.999 AND SO NOT JUST TREATING, WHICH IS CONVENTIONAL MEDICINE TODAY. 00:06:47.099 --> 00:06:48.867 ALL WE DO IS TREAT SYMPTOMS. 00:06:48.967 --> 00:06:51.200 YOU HAVE A SYMPTOM, YOU TAKE A DRUG FOR THE SYMPTOM. 00:06:51.300 --> 00:06:53.966 BUT NOBODY'S ADDRESSING, WHY DID YOU GET CANCER? 00:06:54.066 --> 00:06:55.333 WHY DO YOU HAVE HEART DISEASE? 00:06:55.433 --> 00:06:56.900 WHY DO YOU HAVE ERECTILE DYSFUNCTION? 00:06:57.000 --> 00:06:59.066 WHY DO YOU HAVE HIGH BLOOD PRESSURE? 00:06:59.166 --> 00:07:01.766 THEY WANT TO GIVE YOU DRUGS TO AFFECT IT, 00:07:01.866 --> 00:07:05.000 BUT NOT UNDERSTANDING WHAT MAY BE CONTRIBUTING TO 00:07:05.100 --> 00:07:07.600 THE ROOT CAUSE OF THAT OR THE SYMPTOMS THAT DEVELOP 00:07:07.700 --> 00:07:08.933 FROM FAILED SYSTEMS. 00:07:09.033 --> 00:07:11.033 REBECCA: AND THAT'S WHY OUR HEALTHCARE SYSTEM, 00:07:11.133 --> 00:07:14.000 THE MEDICAL SYSTEM, IS BROKEN AND WHY SO MANY PEOPLE 00:07:14.100 --> 00:07:15.733 END UP KIND OF LIKE YOUR DAD, 00:07:15.833 --> 00:07:18.633 THEY END UP GETTING SOMETIMES WORSE THAN BETTER 00:07:18.733 --> 00:07:20.066 BECAUSE THEY DIDN'T GET THE BEST TREATMENT 00:07:20.166 --> 00:07:21.633 BECAUSE THE SYSTEM IN AND OF ITSELF 00:07:21.733 --> 00:07:23.366 IS NOT MAYBE THE BEST SYSTEM. 00:07:23.466 --> 00:07:25.400 DR. BRYAN: WELL, I WAS IN THAT SYSTEM FOR 20 YEARS 00:07:25.500 --> 00:07:26.833 AS A STUDENT. 00:07:26.933 --> 00:07:30.033 AND THEN I TAUGHT WHAT'S CALLED PATIENT-ORIENTED PROBLEM-SOLVING 00:07:30.133 --> 00:07:31.933 TO MEDICAL STUDENTS. 00:07:32.033 --> 00:07:33.633 AND THEN WHEN I WAS ON FACULTY AT UT, 00:07:33.733 --> 00:07:35.833 WE TAUGHT FUTURE PHYSICIANS. 00:07:35.933 --> 00:07:38.066 IT'S A TEACHING, IT'S A MEDICAL SCHOOL, 00:07:38.166 --> 00:07:39.933 A TEACHING SYSTEM. 00:07:40.033 --> 00:07:41.266 AND FOR ME, THE EPIPHANY WAS, LOOK, 00:07:41.366 --> 00:07:43.366 WE DO A GOOD JOB OF TEACHING ANATOMY, 00:07:43.466 --> 00:07:48.300 PHYSIOLOGY, BIOCHEMISTRY AND THE BASIC CORE SCIENCES. 00:07:48.400 --> 00:07:50.300 BUT THEN THE WAY THE CURRICULUM WORKS IS, 00:07:50.400 --> 00:07:51.400 THOSE NEXT TWO YEARS, 00:07:51.500 --> 00:07:53.133 YOU GO OFF AND YOU'RE DOING CLINICAL ROTATIONS 00:07:53.233 --> 00:07:55.299 AND YOU'RE LEARNING THE PRACTICE OF MEDICINE. 00:07:55.399 --> 00:07:57.400 DIAGNOSING, ICD-10 CODES. 00:07:57.500 --> 00:07:58.500 AND THEN ONCE YOU MAKE A DIAGNOSIS, 00:07:58.600 --> 00:08:01.766 HERE'S YOUR RECIPE FOR HOW YOU TREAT THEM. 00:08:01.866 --> 00:08:03.133 AND IF YOU VENTURE OUTSIDE OF THAT, 00:08:03.233 --> 00:08:06.933 YOU'RE NOT PRACTICING THE STANDARD OF CARE, 00:08:07.033 --> 00:08:08.733 AND IT COULD PUT YOUR LICENSE AT RISK. 00:08:08.833 --> 00:08:09.733 REBECCA: YEAH. 00:08:09.833 --> 00:08:10.566 DR. BRYAN: AND THEN THE EPIPHANY, WELL, 00:08:10.666 --> 00:08:11.466 WHY IS THIS? 00:08:11.566 --> 00:08:14.266 AND THEN MEDICINE IS A BUSINESS. 00:08:14.366 --> 00:08:17.000 IT IS A FOR-PROFIT BUSINESS. 00:08:17.100 --> 00:08:19.833 AND AS AN ENTREPRENEUR AND AS A CAPITALIST, 00:08:19.933 --> 00:08:21.399 THE NUMBER ONE RULE OF BUSINESS IS, 00:08:21.499 --> 00:08:25.000 GET A CUSTOMER AND KEEP THAT CUSTOMER AS LONG AS YOU CAN. 00:08:25.100 --> 00:08:27.933 THAT'S EVERYBODY'S GOAL. 00:08:28.033 --> 00:08:29.966 AND MEDICINE IS THE BEST BUSINESS OUT THERE. 00:08:30.066 --> 00:08:31.400 IT'S A TRILLION-DOLLAR INDUSTRY. 00:08:31.500 --> 00:08:33.100 AND ONCE THEY GET A CUSTOMER, 00:08:33.200 --> 00:08:36.033 THEY PUT YOU ON THAT HAMPSTER WHEEL AND YOU NEVER GET OFF. 00:08:36.133 --> 00:08:38.033 AND IT'S NEVER, HOW DO WE GET YOU OFF OF THESE DRUGS? 00:08:38.133 --> 00:08:39.633 IT'S YOU'RE GOING TO DEVELOP THIS SYMPTOM, 00:08:39.733 --> 00:08:40.733 I'M GOING TO PUT YOU ON ANOTHER DRUG. 00:08:40.833 --> 00:08:41.733 THAT DRUG'S GOING TO CAUSE A SYMPTOM, 00:08:41.833 --> 00:08:43.500 I'M GOING TO PUT YOU ON ANOTHER DRUG. 00:08:43.600 --> 00:08:45.133 AND NOW THE LIFETIME VALUE OF THAT CUSTOMER 00:08:45.233 --> 00:08:48.100 IS THE BEST BUSINESS MODEL IN THE WORLD. 00:08:48.200 --> 00:08:49.400 AND THAT'S THE PROBLEM. 00:08:49.500 --> 00:08:50.599 REBECCA: YEAH, IT IS. 00:08:50.699 --> 00:08:52.766 AND ONCE PEOPLE CAN -- THAT'S THE FIRST STEP 00:08:52.866 --> 00:08:55.033 IN GETTING PEOPLE I THINK TO UNDERSTAND WELLNESS 00:08:55.133 --> 00:08:58.266 IS UNDERSTANDING WHERE THE SYSTEM IS BROKEN 00:08:58.366 --> 00:09:00.700 AND BEING AWARE OF THAT, AND THEN MOVING FORWARD TOO. 00:09:00.800 --> 00:09:03.967 AND I THINK THAT FIRST POINT THAT YOU SAID IS SO IMPORTANT, 00:09:04.067 --> 00:09:07.766 THAT ALL SICKNESS COMES FROM EITHER TOXINS 00:09:07.866 --> 00:09:11.066 OR A LACK OF NUTRITIONAL DEFICIENCIES, RIGHT? 00:09:11.166 --> 00:09:11.833 DR. BRYAN: THAT'S RIGHT. 00:09:11.933 --> 00:09:12.900 REBECCA: THAT'S RIGHT. 00:09:13.000 --> 00:09:15.033 THAT'S ACTUALLY VERY HELPFUL TO TELL PEOPLE. 00:09:15.133 --> 00:09:18.267 DR. BRYAN: WHEN YOU IMPLEMENT THAT PHILOSOPHY, 00:09:18.367 --> 00:09:21.166 WE'RE NEVER DEFICIENT IN CHOLESTEROL-LOWERING MEDICATION. 00:09:21.266 --> 00:09:22.967 WE'RE NEVER DEFICIENT IN SYNTHETIC COMPOUNDS 00:09:23.067 --> 00:09:25.267 THAT INHIBIT BIOCHEMICAL REACTIONS. 00:09:25.367 --> 00:09:26.699 IN FACT, THEY'RE CAUSING TOXICITY. 00:09:26.799 --> 00:09:29.133 AND MANY OF THEM LEAD TO NUTRIENT DEFICIENCIES. 00:09:29.233 --> 00:09:32.800 SO IT'S CONTRIBUTING TO THE CYCLE OF CHRONIC DISEASE. 00:09:32.900 --> 00:09:35.567 AND THAT'S WHY AMERICANS ARE THE SICKEST PEOPLE ON THE PLANET 00:09:35.667 --> 00:09:38.167 BECAUSE WE DON'T ADDRESS THE ROOT CAUSE. 00:09:38.267 --> 00:09:39.300 REBECCA: YEAH. 00:09:39.400 --> 00:09:40.900 AND THEN WHEN YOU GO INTO, LIKE YOU SAID, OUR FOOD, 00:09:41.000 --> 00:09:43.466 OUR WATER, WHAT THEY'VE DONE TO OUR SOIL, 00:09:43.566 --> 00:09:44.699 WHICH IS AFFECTING OUR FOOD, 00:09:44.799 --> 00:09:45.966 THE STUFF THAT'S IN OUR AIR, 00:09:46.066 --> 00:09:49.367 THE STUFF THAT'S IN OUR WATER IS FULL OF SO MANY THINGS. 00:09:49.467 --> 00:09:52.799 THERE'S SO MANY DIFFERENT WAYS FOR BEING BOMBARDED CHEMICALLY. 00:09:52.899 --> 00:09:54.599 AND HONESTLY MOST PEOPLE AREN'T EVEN AWARE OF IT, 00:09:54.699 --> 00:09:57.733 OUR PRODUCTS THAT WE USE IN OUR HOMES EVERY SINGLE DAY, 00:09:57.833 --> 00:10:01.733 WE ARE REALLY BOMBARDING OUR BODIES WITH -- 00:10:01.833 --> 00:10:03.067 AND THEN WE'RE NOT DETOXING WELL, 00:10:03.167 --> 00:10:04.533 BECAUSE WE DON'T EVEN KNOW HOW TO DETOX. 00:10:04.633 --> 00:10:06.066 DR. BRYAN: NO, LOOK. 00:10:06.166 --> 00:10:09.833 WE DETOX THROUGH BREATHING, URINATION, 00:10:09.933 --> 00:10:11.300 DEFECATION, AND SWEATING. 00:10:11.400 --> 00:10:12.366 REBECCA: AND SWEATING. 00:10:12.466 --> 00:10:13.800 DR. BRYAN: AND NOBODY SWEATS ANYMORE, RIGHT. 00:10:13.900 --> 00:10:14.933 REBECCA: NO ONE SWEATS. 00:10:15.033 --> 00:10:17.299 AND MOST PEOPLE HAVE PROBLEMS USING THE BATHROOM. 00:10:17.399 --> 00:10:18.499 MOST PEOPLE ARE CONSTIPATED. 00:10:18.599 --> 00:10:19.299 I MEAN, I'M SORRY. 00:10:19.399 --> 00:10:20.333 MOST PEOPLE ARE CONSTIPATED. 00:10:20.433 --> 00:10:21.666 DR. BRYAN: YEAH. 00:10:21.766 --> 00:10:23.466 AND SO YOU GET TOXINS THAT BUILD UP THAT YOU CAN'T GET RID OF. 00:10:23.566 --> 00:10:24.566 REBECCA: EXACTLY. 00:10:24.666 --> 00:10:26.199 AND PEOPLE AREN'T EVEN AWARE OF IT. 00:10:26.299 --> 00:10:27.633 YEAH. 00:10:27.733 --> 00:10:30.366 AND SO THIS IS WHY WHAT YOU'RE DOING WITH NITRIC OXIDE 00:10:30.466 --> 00:10:32.266 IS SO IMPERATIVE. 00:10:32.366 --> 00:10:34.066 AND WHAT I LOVE ABOUT IT IS BECAUSE YOU'RE NOT 00:10:34.166 --> 00:10:37.433 CREATING SOMETHING SYNTHETIC TO TREAT A SYMPTOM, 00:10:37.533 --> 00:10:39.700 WHICH IS YOU SAID THE WORD... 00:10:39.800 --> 00:10:40.600 DR. BRYAN: PHARMACOLOGY. 00:10:40.700 --> 00:10:42.967 PHARMACOLOGY IS THE APPLICATION OF 00:10:43.067 --> 00:10:46.833 USUALLY SYNTHETIC COMPOUNDS THAT ARE TARGETED TO A SPECIFIC, 00:10:46.933 --> 00:10:51.099 WHAT I CALL A SYMPTOMOLOGY OF A DISEASE, 00:10:51.199 --> 00:10:52.400 RIGHT. 00:10:52.500 --> 00:10:55.966 SO THE BEST EXAMPLE WOULD BE CHOLESTEROL-LOWERING MEDICATION, 00:10:56.066 --> 00:10:56.967 RIGHT. 00:10:57.067 --> 00:10:58.533 OUR BODY NATURALLY PRODUCES CHOLESTEROL. 00:10:58.633 --> 00:10:59.200 WHY? 00:10:59.300 --> 00:11:00.667 BECAUSE OUR BODY NEEDS IT. 00:11:00.767 --> 00:11:04.100 AND SO WHEN YOU DEVELOP A COMPOUND THAT INHIBITS 00:11:04.200 --> 00:11:06.733 THE VERY LIMITING STEP OF CHOLESTEROL SYNTHESIS, 00:11:06.833 --> 00:11:09.300 THEN THAT'S PHARMACOLOGY. 00:11:09.400 --> 00:11:10.400 IT'S TARGETED TO 00:11:10.500 --> 00:11:12.200 SPECIFICALLY INHIBIT THAT BIOCHEMICAL REACTION. 00:11:12.300 --> 00:11:15.433 AND WHEN YOU INTERRUPT NATURAL PROCESSES, 00:11:15.533 --> 00:11:17.167 WHEN YOU INTERRUPT NATURE AND INTERFERE WITH NATURE, 00:11:17.267 --> 00:11:18.299 THERE'S ALWAYS SIDE EFFECTS. 00:11:18.399 --> 00:11:21.000 REBECCA: YEAH, IT'S TRUE. 00:11:21.100 --> 00:11:22.233 DR. BRYAN: AND THAT'S WHY MOST DRUGS AREN'T SAFE. 00:11:22.333 --> 00:11:23.499 THERE'S ALWAYS SIDE EFFECTS. 00:11:23.599 --> 00:11:24.866 REBECCA: BUT YOURS IS DIFFERENT. 00:11:24.966 --> 00:11:26.067 WHAT DO YOU DESCRIBE YOURS AS? 00:11:26.167 --> 00:11:27.133 DR. BRYAN: YEAH. 00:11:27.233 --> 00:11:28.766 SO WHAT WE DO IS RESTORE TO PHYSIOLOGY, RIGHT. 00:11:28.866 --> 00:11:30.233 WE DON'T USE SYNTHETIC COMPOUNDS, 00:11:30.333 --> 00:11:34.633 WE DON'T MANUFACTURE AND DEVELOP COMPOUNDS THAT WE CAN PATENT. 00:11:34.733 --> 00:11:35.699 I HAVE A NUMBER OF PATENTS, 00:11:35.799 --> 00:11:39.833 BUT THEY'RE NOT ON NOVEL STRUCTURES OF MATTER. 00:11:39.933 --> 00:11:42.966 BUT WHAT WE DO IS UNDERSTAND WHAT GOES WRONG IN PEOPLE, 00:11:43.066 --> 00:11:44.000 AND THEN HOW DO WE FIX IT. 00:11:44.100 --> 00:11:45.900 AND WE SPOKE SPECIFICALLY ON NITRIC OXIDE. 00:11:46.000 --> 00:11:48.500 SO NUMBER ONE, I HAD TO UNDERSTAND HOW THE HUMAN BODY 00:11:48.600 --> 00:11:50.000 MAKES NITRIC OXIDE. 00:11:50.100 --> 00:11:53.000 NUMBER TWO, SPENT 20 YEARS TRYING TO UNDERSTAND 00:11:53.100 --> 00:11:55.667 WHAT LEADS TO A LOSS OF NITRIC OXIDE PRODUCTION. 00:11:55.767 --> 00:11:58.366 WHAT LEADS TO THE INABILITY TO NATURALLY PRODUCE 00:11:58.466 --> 00:12:01.300 THIS VERY CENTRAL FOUNDATIONAL MOLECULE. 00:12:01.400 --> 00:12:03.266 AND THEN ONCE WE HAD ANSWERS TO THOSE QUESTIONS, 00:12:03.366 --> 00:12:04.200 THEN I FIGURED OUT, OKAY, 00:12:04.300 --> 00:12:05.699 NOW THAT I UNDERSTAND THAT, 00:12:05.799 --> 00:12:07.500 I CAN START TO DEVELOP RATIONAL THERAPY. 00:12:07.600 --> 00:12:08.866 AND SO WHAT WE DO IS, AGAIN, 00:12:08.966 --> 00:12:10.666 HOW MUCH NITRIC OXIDE ARE YOU MAKING? 00:12:10.766 --> 00:12:12.966 WE WANT TO GIVE BACK WHAT'S MISSING. 00:12:13.066 --> 00:12:15.033 THE BEST EXAMPLE OF THIS IS VITAMIN D, RIGHT. 00:12:15.133 --> 00:12:16.200 VITAMIN D'S SIMPLE. 00:12:16.300 --> 00:12:18.499 YOU GO GET A BLOOD DRAW, AND IF YOUR VITAMIN D'S 20, 00:12:18.599 --> 00:12:21.233 YOU TAKE VITAMIN D UNTIL YOUR BLOOD LEVELS GET TO 80. 00:12:21.333 --> 00:12:23.733 SO THAT'S THE EASY WAY TO TRY TREATING IT. 00:12:23.833 --> 00:12:26.066 THE PROBLEM WITH NITRIC OXIDE IS, IT'S A GAS. 00:12:26.166 --> 00:12:27.866 NUMBER ONE, WE CAN'T PICK IT UP IN YOUR BLOOD 00:12:27.966 --> 00:12:29.833 IN A CLINICAL SETTING. 00:12:29.933 --> 00:12:32.766 AND SO WE HAVE TO RELY ON SYMPTOMS AND UNDERSTANDING 00:12:32.866 --> 00:12:35.933 HOW MUCH NITRIC OXIDE A HEALTHY PERSON MAKES IN 24 HOURS 00:12:36.033 --> 00:12:37.500 THROUGH THE PRODUCTION PATHWAYS. 00:12:37.600 --> 00:12:41.733 SO MY GOAL WAS, LET'S GIVE BACK WHAT'S MISSING, 00:12:41.833 --> 00:12:43.700 AND THEN LET'S FIX THE REASON YOUR BODY'S LOST 00:12:43.800 --> 00:12:46.167 THE ABILITY TO PRODUCE IT NATURALLY. 00:12:46.267 --> 00:12:49.299 AND THAT'S WHAT I FOCUSED ON FOR THE PAST 25 YEARS. 00:12:49.399 --> 00:12:52.700 REBECCA: SO HOW DID YOU GET INTRODUCED TO NITRIC OXIDE, 00:12:52.800 --> 00:12:54.666 WE'LL START THERE, AND THEN I WANT TO HEAR 00:12:54.766 --> 00:12:56.699 WHAT DOES NITRIC OXIDE DO IN THE BODY 00:12:56.799 --> 00:12:59.833 AND WHY IT'S SO FOUNDATIONAL FOR OUR HEALTH? 00:12:59.933 --> 00:13:01.399 DR. BRYAN: WELL, I THINK I WAS A FIRST-YEAR STUDENT 00:13:01.499 --> 00:13:04.333 AT LSU SCHOOL OF MEDICINE. 00:13:04.433 --> 00:13:05.967 A NOBEL PRIZE HAD JUST BEEN AWARDED, 00:13:06.067 --> 00:13:09.000 AND THIS WAS 1998 FOR THE DISCOVERY OF NITRIC OXIDE 00:13:09.100 --> 00:13:11.366 AS A SIGNALING MOLECULE IN THE CARDIOVASCULAR SYSTEM. 00:13:11.466 --> 00:13:14.433 SO, OBVIOUSLY, EVERY YEAR IN, I BELIEVE IT'S AUGUST, 00:13:14.533 --> 00:13:15.533 THE NOBEL PRIZE IS AWARDED, 00:13:15.633 --> 00:13:17.767 AND THEN THE PRIZE IS -- OR ANNOUNCED, 00:13:17.867 --> 00:13:20.067 AND IT'S AWARDED, I THINK, IN DECEMBER. 00:13:20.167 --> 00:13:21.533 SO THE GUY THAT WON THE NOBEL PRIZE, 00:13:21.633 --> 00:13:22.799 THERE WERE THREE SCIENTISTS, 00:13:22.899 --> 00:13:25.699 AND ONE OF THEM, LOU IGNARRO, CAME TO THE MEDICAL SCHOOL 00:13:25.799 --> 00:13:29.100 AND GAVE A LECTURE AND TOLD ABOUT HIS STORY OF DISCOVERY 00:13:29.200 --> 00:13:32.133 AND JOURNEY AND WHAT LED TO A NOBEL PRIZE. 00:13:32.233 --> 00:13:34.566 AND HE SAID TO ME, HE GOES, NATHAN, IF WE CAN FIGURE OUT 00:13:34.666 --> 00:13:36.799 HOW TO SAFELY AND EFFECTIVELY RESTORE NITRIC OXIDE PRODUCTION 00:13:36.899 --> 00:13:37.566 IN THE HUMAN BODY, 00:13:37.666 --> 00:13:38.966 IT'LL CHANGE THE WORLD. 00:13:39.066 --> 00:13:41.333 AND IT'LL CHANGE THE MANAGEMENT OF DISEASE, 00:13:41.433 --> 00:13:42.967 BECAUSE THERE'S NOT A SINGLE HUMAN DISEASE 00:13:43.067 --> 00:13:45.733 WHERE NITRIC OXIDE WOULDN'T BE BENEFICIAL. 00:13:45.833 --> 00:13:49.300 AND I GO, THAT'S A PRETTY PROFOUND STATEMENT. 00:13:49.400 --> 00:13:52.099 SO FORTUNATELY, I TRAINED UNDER A PHARMACOLOGIST, 00:13:52.199 --> 00:13:54.733 MARTIN FEELISCH HAD BEEN IN THE NITRIC OXIDE FIELD 00:13:54.833 --> 00:13:57.366 FOR 20 YEARS PRIOR. 00:13:57.466 --> 00:13:59.233 AND WE DEVELOPED ANALYTICAL METHODS 00:13:59.333 --> 00:14:02.800 WHERE WE COULD DETECT NITRIC OXIDE GAS IN BIOLOGICAL SYSTEMS. 00:14:02.900 --> 00:14:04.699 AND THAT NOW CREATED FOR US WHAT WE CALLED 00:14:04.799 --> 00:14:06.366 A FINGERPRINT OF INNOBIOLOGY, 00:14:06.466 --> 00:14:10.333 HEART DISEASE, DIABETES, TRANSPLANT SURGERIES, 00:14:10.433 --> 00:14:12.666 THINGS LIKE THAT. 00:14:12.766 --> 00:14:15.167 AND SO THEN THAT ALLOWED ME TO FIGURE OUT HOW TO 00:14:15.267 --> 00:14:16.633 MAKE NITRIC OXIDE, RIGHT. 00:14:16.733 --> 00:14:17.866 BECAUSE NITRIC OXIDE'S A GAS, 00:14:17.966 --> 00:14:20.800 AND ONCE IT'S PRODUCED, IT'S GONE IN LESS THAN A SECOND. 00:14:20.900 --> 00:14:24.499 SO PART OF MY CHALLENGE WAS, 00:14:24.599 --> 00:14:26.133 WHEN NITRIC OXIDE'S PRODUCED, 00:14:26.233 --> 00:14:28.567 WHERE DOES IT GO, WHAT DOES IT BECOME, 00:14:28.667 --> 00:14:30.300 AND THEN WHAT DOES IT DO? 00:14:30.400 --> 00:14:32.033 AND THEN ONCE WE FIGURE THAT OUT, THEN I THOUGHT, 00:14:32.133 --> 00:14:34.266 OKAY, WELL, NOW IF I MAKE NITRIC OXIDE, 00:14:34.366 --> 00:14:36.933 I CAN CONTROL AND DICTATE THE METABOLIC FATE OF NITRIC OXIDE, 00:14:37.033 --> 00:14:40.300 NOW I CAN DEVELOP SAFE AND EFFECTIVE THERAPIES. 00:14:40.400 --> 00:14:41.333 SO THOSE WERE -- 00:14:41.433 --> 00:14:43.333 THERE WAS MULTIPLE DISCOVERIES OF EPIPHANIES 00:14:43.433 --> 00:14:48.766 ALONG THE WAY IN MY SCIENCE CAREER AND DISCOVERY 00:14:48.866 --> 00:14:51.833 THAT ALLOWED ME TO THINK A LITTLE BIT DIFFERENTLY. 00:14:51.933 --> 00:14:53.100 YOU KNOW, THERE'S A FAMOUS QUOTE SAYING, 00:14:53.200 --> 00:14:54.699 RESEARCH IS TO SEE WHAT OTHERS ARE SEEING 00:14:54.799 --> 00:14:56.733 AND TO THINK WHAT NO ONE ELSE HAS THOUGHT. 00:14:56.833 --> 00:14:58.333 AND THAT'S ALWAYS BEEN LIKE ADDING PRINCIPLE. 00:14:58.433 --> 00:15:00.233 BECAUSE THERE'S A LOT OF NOISE OUT THERE. 00:15:00.333 --> 00:15:02.100 SO I CAN SEE WHAT EVERYONE ELSE IS SEEING, 00:15:02.200 --> 00:15:04.166 BUT I HAD TO THINK A LITTLE BIT DIFFERENTLY 00:15:04.266 --> 00:15:06.233 AND THINK WHAT NO ONE ELSE HAS THOUGHT. 00:15:06.333 --> 00:15:08.033 AND WHEN I SAID I COULD MAKE A SOLID DOSE FORM 00:15:08.133 --> 00:15:11.067 OF NITRIC OXIDE GAS, PEOPLE SAID IT WASN'T POSSIBLE. 00:15:11.167 --> 00:15:12.766 YOU'RE TRYING TO DO THE IMPOSSIBLE 00:15:12.866 --> 00:15:14.466 AND YOU'RE GOING TO KILL PEOPLE. 00:15:14.566 --> 00:15:18.466 SO I IGNORED THE NOISE AND KEPT MY HEAD DOWN 00:15:18.566 --> 00:15:21.366 AND FOCUSED ON WHAT I KNEW WAS IMPORTANT. 00:15:21.466 --> 00:15:25.133 AND WE'VE PROVEN A LOT OF THE DISBELIEVERS WRONG. 00:15:25.233 --> 00:15:26.733 REBECCA: I THINK THAT'S SO IMPORTANT, TOO, 00:15:26.833 --> 00:15:29.300 AND I THINK ANYONE THAT'S EVER CHANGED HISTORY 00:15:29.400 --> 00:15:31.433 OR HAS MADE AN IMPACT, THEY HAD TO HAVE THAT KIND OF MENTALITY, 00:15:31.533 --> 00:15:34.267 BECAUSE YOU'RE HAVING TO PIONEER AND PAVE A WAY 00:15:34.367 --> 00:15:35.600 THAT NO ONE -- AND A LOT OF TIMES, 00:15:35.700 --> 00:15:36.800 PEOPLE ARE LIKE, YOU'RE CRAZY. 00:15:36.900 --> 00:15:40.166 AND IF YOU CARE TOO MUCH WHAT PEOPLE THINK, 00:15:40.266 --> 00:15:41.500 YOU'RE GOING TO STOP WHAT YOU'RE DOING 00:15:41.600 --> 00:15:43.100 AND THINK ABOUT EVERYTHING THAT'S HAPPENED 00:15:43.200 --> 00:15:44.600 BECAUSE YOU KEPT MOVING FORWARD. 00:15:44.700 --> 00:15:47.100 WHAT DO YOU THINK WAS ONE OF THE THINGS THAT PROPELLED YOU? 00:15:47.200 --> 00:15:48.166 DR. BRYAN: THE DOUBT. 00:15:48.266 --> 00:15:50.599 I'M PROBABLY ONE OF THE HARD-HEADEST PEOPLE 00:15:50.699 --> 00:15:56.200 THAT MY PARENTS TELL ME, EVERYBODY TELLS ME THIS. 00:15:56.300 --> 00:15:57.466 BUT IT WAS THE DOUBT. 00:15:57.566 --> 00:16:00.467 I BELIEVED THAT WHEN PEOPLE -- THE WORST THING YOU CAN DO 00:16:00.567 --> 00:16:01.833 IS TELL ME NO. 00:16:01.933 --> 00:16:05.099 BECAUSE I'M GOING TO BE PRETTY MOTIVATED TO PROVE YOU WRONG, 00:16:05.199 --> 00:16:07.133 AND WHEN PEOPLE STARTED DOUBTING WHAT I WAS DOING, 00:16:07.233 --> 00:16:08.767 TOLD ME COULDN'T BE DONE OR THERE WERE TOO MANY -- 00:16:08.867 --> 00:16:10.400 REBECCA: YOU USED IT AS LIKE FUEL TO PUSH YOU FURTHER? 00:16:10.500 --> 00:16:11.267 DR. BRYAN: IT'S FUEL. 00:16:11.367 --> 00:16:12.433 IT FUELED THE FLAME. 00:16:12.533 --> 00:16:13.966 REBECCA: THAT'S GOOD. 00:16:14.066 --> 00:16:15.700 SO THAT'S TO PARENTS, TOO, IF YOU'RE WATCHING THIS 00:16:15.800 --> 00:16:17.800 AND IF YOU HAVE A KID LIKE THAT, THAT'S ACTUALLY, 00:16:17.900 --> 00:16:19.399 I THINK SOMETIMES PEOPLE ARE LIKE, UGH, 00:16:19.499 --> 00:16:20.700 AND I'M LIKE, NO, THAT'S NOT -- 00:16:20.800 --> 00:16:21.567 DR. BRYAN: FEAR TO FAIL. 00:16:21.667 --> 00:16:22.733 FEAR OF FAILURE. 00:16:22.833 --> 00:16:25.600 I'M NOT FEARFUL OF FAILURE. 00:16:25.700 --> 00:16:27.699 MY FEAR IS IN FEAR OF DISAPPOINTMENT 00:16:27.799 --> 00:16:29.266 AND FEAR OF LETTING PEOPLE DOWN, 00:16:29.366 --> 00:16:30.933 BUT IT'S NEVER BEEN A FEAR OF FAILURE, 00:16:31.033 --> 00:16:34.233 AND I THINK WE HAVE TO TRAIN OUR KIDS TO, 00:16:34.333 --> 00:16:37.333 IF YOU HAVEN'T FAILED, YOU HAVEN'T TRIED, RIGHT. 00:16:37.433 --> 00:16:40.433 FAILURE IS A VERY IMPORTANT LESSON IN LIFE. 00:16:40.533 --> 00:16:43.467 BUT IT'S NOT -- FAILURE'S NOT FALLING DOWN, 00:16:43.567 --> 00:16:44.966 IT'S HOW MANY TIMES YOU FALL, 00:16:45.066 --> 00:16:46.199 IT'S HOW MANY TIMES YOU GET UP. 00:16:46.299 --> 00:16:47.133 RIGHT. 00:16:47.233 --> 00:16:49.000 AND SO FOR ME, THAT WAS A DRIVER. 00:16:49.100 --> 00:16:52.400 AND THE OTHER THING, I READ A LOT AS A KID, 00:16:52.500 --> 00:16:54.166 AND EVEN WHEN I WAS GOING THROUGH SCHOOL, 00:16:54.266 --> 00:16:56.033 AND ONE OF THESE, SCHOPENHAUER, 00:16:56.133 --> 00:16:58.766 HE'S A GERMAN PHILOSOPHER, AND HE SAID THAT WHEN YOU 00:16:58.866 --> 00:17:01.833 ESTABLISH A TRUTH, AND SO THESE ARE FUNDAMENTAL TRUTHS, 00:17:01.933 --> 00:17:04.167 RIGHT, ALL TRUTHS GO THROUGH THREE PHASES. 00:17:04.267 --> 00:17:05.900 FIRST, THEY'RE RIDICULED. 00:17:06.000 --> 00:17:07.967 THEN SECONDLY THEY'RE VIOLENTLY OPPOSED. 00:17:08.067 --> 00:17:11.900 AND THEN THIRD, THEY'RE REVEALED AS BEING SELF-EVIDENT. 00:17:12.000 --> 00:17:14.500 SO WHEN I WAS GOING THROUGH THESE DISCOVERIES, 00:17:14.600 --> 00:17:16.400 I KNEW THAT THESE WERE FUNDAMENTAL TRUTHS. 00:17:16.500 --> 00:17:19.433 THESE WERE TRUTHS OF PHYSIOLOGY AND HOW THE HUMAN BODY WORKS. 00:17:19.533 --> 00:17:21.833 SO, NUMBER ONE, I SURVIVED THE RIDICULE. 00:17:21.933 --> 00:17:24.199 ALL MY ACADEMIC COLLEAGUES RIDICULED ME. 00:17:24.299 --> 00:17:26.633 THERE WAS A VIOLENT OPPOSITION. 00:17:26.733 --> 00:17:29.567 IT'S A COMPLETE VIOLENT OPPOSITION FROM COMPETITORS, 00:17:29.667 --> 00:17:32.033 FROM BIG COMPANIES. 00:17:32.133 --> 00:17:33.900 I'VE BEEN SUBJECT OF MULTIPLE LAWSUITS 00:17:34.000 --> 00:17:35.567 TRYING TO DEPLETE ME OF MY RESOURCES, 00:17:35.667 --> 00:17:37.600 TRYING TO DRAIN US FINANCIALLY 00:17:37.700 --> 00:17:39.799 AND KEEP WHAT WE'RE DOING FROM GETTING OUT THERE 00:17:39.866 --> 00:17:41.933 AND REVEALING THE TRUTH. 00:17:42.033 --> 00:17:44.400 BUT I'VE BEEN RIDICULED, I'VE BEEN VIOLENTLY OPPOSED. 00:17:44.500 --> 00:17:45.833 WHAT'S THE NEXT STEP? 00:17:45.933 --> 00:17:47.000 IT'S SELF-EVIDENT. 00:17:47.100 --> 00:17:48.333 REBECCA: YEAH. 00:17:48.433 --> 00:17:50.066 DR. BRYAN: AND THAT'S -- WE'RE ENTERING THIS THIRD PHASE 00:17:50.166 --> 00:17:51.733 OF THESE TRUTHS THAT WE'VE DISCOVERED. 00:17:51.833 --> 00:17:52.800 REBECCA: YEAH. 00:17:52.900 --> 00:17:55.666 AND PEOPLE ARE STARTING TO SEE THE BENEFITS. 00:17:55.766 --> 00:17:57.100 AND GOD HAS TO BE BEHIND IT, TOO, 00:17:57.200 --> 00:17:58.999 BECAUSE I THINK TOO IN SOMEONE THAT'S LIKE, 00:17:59.099 --> 00:18:00.733 IF YOU'RE A DAVID AND YOU'RE FACING A GOLIATH, 00:18:00.833 --> 00:18:03.533 ONLY GOD CAN LIKE SUSTAIN YOU. 00:18:03.633 --> 00:18:04.367 DR. BRYAN: THAT'S RIGHT, HE'S MY SLINGSHOT. 00:18:04.467 --> 00:18:05.000 REBECCA: YEAH. 00:18:05.100 --> 00:18:05.567 THAT'S RIGHT. 00:18:05.667 --> 00:18:06.500 THAT'S AWESOME. 00:18:06.600 --> 00:18:07.599 THAT'S SO COOL. 00:18:07.699 --> 00:18:08.367 I LOVE THAT. 00:18:08.467 --> 00:18:09.700 I'M ALWAYS INSPIRED. 00:18:09.800 --> 00:18:12.467 AND IT'S INSPIRING TO ME TO HEAR STORIES OF PEOPLE WHO PERSEVERE, 00:18:12.567 --> 00:18:14.333 BECAUSE I THINK OTHER PEOPLE, 00:18:14.433 --> 00:18:15.866 THEY'LL PERSEVERE, 00:18:15.966 --> 00:18:18.266 BUT THEN THEY ALLOW THEMSELVES TO GET INTIMIDATED. 00:18:18.366 --> 00:18:19.633 AND I WAS TALKING TO MY HUSBAND THIS MORNING 00:18:19.733 --> 00:18:21.933 ABOUT THAT STORY IN THE BIBLE WHERE HE TELLS HIS PEOPLE 00:18:22.033 --> 00:18:23.700 TO GO INTO THE PROMISED LAND AND THEY GO, WELL, 00:18:23.800 --> 00:18:25.233 THERE'S GIANTS IN THERE. 00:18:25.333 --> 00:18:28.333 AND SO A WHOLE GENERATION WEREN'T ABLE TO ENTER 00:18:28.433 --> 00:18:29.833 UNTIL ONLY JOSHUA AND CALEB, 00:18:29.933 --> 00:18:31.766 THEY WERE THE ONLY TWO THAT SAID, WE CAN DO THIS. 00:18:31.866 --> 00:18:33.167 GOD'S ON OUR SIDE. 00:18:33.267 --> 00:18:35.567 SO YOU HAVE TO HAVE THAT MENTALITY THAT IF GOD IS FOR US, 00:18:35.667 --> 00:18:37.266 WHO CAN BE AGAINST US? 00:18:37.366 --> 00:18:38.533 DR. BRYAN: YEAH, FOR SURE. 00:18:38.633 --> 00:18:40.633 LOOK, THERE HASN'T BEEN A DAY I DIDN'T WAKE UP IN PRAYER 00:18:40.733 --> 00:18:41.799 AND GRATITUDE. 00:18:41.899 --> 00:18:45.066 AND EVEN THE DIMMEST OF TIMES AND THE DARKEST OF TIMES 00:18:45.166 --> 00:18:48.033 AND THE SLIMMEST TIMES FINANCIALLY WITH NO RESOURCES 00:18:48.133 --> 00:18:50.233 AND REALLY BETTING THE FARM, 00:18:50.333 --> 00:18:53.533 BETTING EVERYTHING WE HAD, ON THIS DREAM 00:18:53.633 --> 00:18:55.666 AND THIS VISION I HAD. 00:18:55.766 --> 00:18:58.833 AND THEN TO JUST, IF IT'S MEANT TO BE, BELIEVE ME, 00:18:58.933 --> 00:19:01.199 GOD, YOUR WILL BE DONE, NOT MINE. 00:19:01.299 --> 00:19:03.566 AND IT'S JUST, IT'S GUIDED ME OF GIVING ME DIRECTION 00:19:03.666 --> 00:19:07.866 AND GIVING ME REALLY CONFIDENCE TO KNOW THAT 00:19:07.966 --> 00:19:12.500 WHAT WE'RE DOING IS THE RIGHT THING BECAUSE WHAT I RECOGNIZED 00:19:12.600 --> 00:19:17.933 EARLY ON IS THE BENEFIT AND THE POWER OF NITRIC OXIDE. 00:19:18.033 --> 00:19:20.633 TREATING MY DAD'S NON-HEALING WOUNDS, 00:19:20.733 --> 00:19:22.733 GETTING HIM OFF PRESCRIPTION MEDICATION, 00:19:22.833 --> 00:19:26.167 BLOOD PRESSURE MEDICINE, THIS PEDIATRIC PATIENT 00:19:26.267 --> 00:19:28.733 WE PUBLISHED ON A TEXAS CHILDREN'S HOSPITAL IN 2011, 00:19:28.833 --> 00:19:31.900 SAVING HIS LIFE WHEN ALL PRESCRIPTION MEDICATION FAILED 00:19:32.000 --> 00:19:33.500 AND HE WAS IN A HYPERTENSIVE CRISIS 00:19:33.600 --> 00:19:34.966 AND WE JUST GAVE HIM OUR NITRIC OXIDE, 00:19:35.066 --> 00:19:38.199 SAVED HIS LIFE, IMPROVED HIS COGNITION, 00:19:38.299 --> 00:19:39.266 IT REVERSED HIS HEART DISEASE, 00:19:39.366 --> 00:19:40.767 REVERSED HIS KIDNEY DISEASE. 00:19:40.867 --> 00:19:41.700 REBECCA: THAT'S AMAZING. 00:19:41.800 --> 00:19:42.900 DR. BRYAN: AND THEN NOW, 00:19:43.000 --> 00:19:45.367 EVERY DAY WHEN I WAKE UP, I'VE GOT HUNDREDS OF TEXTS, 00:19:45.467 --> 00:19:48.866 EMAILS, AND VOICE MAILS OF, YOU'VE SAVED MY LIFE, THANK YOU. 00:19:48.966 --> 00:19:53.600 THERE'S NOTHING MORE GRATIFYING THAN BEING 00:19:53.700 --> 00:19:55.733 INVOLVED IN CHANGING SOMEONE'S LIFE. 00:19:55.833 --> 00:19:57.633 AND CERTAINLY IT'S SAID IF YOU'VE CHANGED 00:19:57.733 --> 00:19:59.833 ONE PERSON'S LIFE, YOU'VE CHANGED THE WORLD 00:19:59.933 --> 00:20:02.066 AND YOU'VE CHANGED THEIR WORLD, FOR SURE. 00:20:02.166 --> 00:20:04.700 SO THAT'S MY GUIDING LIGHT, MY PRINCIPLE. 00:20:04.800 --> 00:20:07.766 BUT IT'S ALL, IT'S DIVINE INTERVENTION 00:20:07.866 --> 00:20:10.833 BECAUSE WHEN I LOOK AT WHERE I AM, WHERE I'VE BEEN, 00:20:10.933 --> 00:20:13.233 AND PERHAPS EVEN WHERE I'M GOING, 00:20:13.333 --> 00:20:16.767 IT'S ALL -- I COULDN'T HAVE SCRIPTED THIS. 00:20:16.867 --> 00:20:18.900 IT CERTAINLY HAD BEEN GOD LEADING ME ALONG THE WAY. 00:20:19.000 --> 00:20:20.300 REBECCA: SOMEONE'S GUIDING ME. 00:20:20.400 --> 00:20:21.767 DR. BRYAN: TEACHING ME A LOT OF LESSONS ALONG THE WAY, TOO. 00:20:21.867 --> 00:20:22.833 REBECCA: I KNOW. 00:20:22.933 --> 00:20:24.499 AND IT'S ALWAYS IN THE HARDEST THINGS, USUALLY, 00:20:24.599 --> 00:20:26.399 THE BEST LESSONS ARE LEARNED. 00:20:26.499 --> 00:20:31.966 SO NITRIC OXIDE, WHAT IS IT, WHY IS IT IMPORTANT? 00:20:32.066 --> 00:20:35.133 DR. BRYAN: WELL, IT'S WHAT WE CALL A SIGNALING MOLECULE. 00:20:35.233 --> 00:20:38.033 SO IT'S HOW CELLS IN THE BODY COMMUNICATE WITH ONE ANOTHER. 00:20:38.133 --> 00:20:41.766 AND THE BEST EXAMPLE IS IN THE LINING OF THE BLOOD VESSEL. 00:20:41.866 --> 00:20:44.666 SO THERE'S THIS SINGLE LAYER OF CELLS IN THE BLOOD VESSEL 00:20:44.766 --> 00:20:46.333 CALLED ENDOTHELIAL CELLS. 00:20:46.433 --> 00:20:49.167 PRODUCE NITRIC OXIDE, IT DIFFUSES INTO THE SMOOTH MUSCLE, 00:20:49.267 --> 00:20:51.400 AND IT CAUSES SMOOTH MUSCLE RELAXATION, 00:20:51.500 --> 00:20:53.099 AND BLOOD VESSELS DILATE. 00:20:53.199 --> 00:20:56.500 SO NOW WE'RE IMPROVING BLOOD FLOW AND TISSUE OXYGENATION. 00:20:56.600 --> 00:20:59.433 BUT IT ACTUALLY CONTROLS HOW OXYGEN IS DELIVERED 00:20:59.533 --> 00:21:00.666 ON THE HEMOGLOBIN MOLECULE. 00:21:00.766 --> 00:21:04.367 IT REGULATES THE UPTAKE AND DELIVERY OF OXYGEN. 00:21:04.467 --> 00:21:06.066 BUT IT'S MUCH MORE THAN A VASAL DILATER. 00:21:06.166 --> 00:21:07.699 IT MOBILIZES OUR STEM CELLS, 00:21:07.799 --> 00:21:09.199 IT ACTIVATES OUR MITOCHONDRIA 00:21:09.299 --> 00:21:11.400 SO THAT WE CAN IMPROVE ENERGY PRODUCTION 00:21:11.500 --> 00:21:12.866 AT THE CELLULAR LEVEL. 00:21:12.966 --> 00:21:13.833 REBECCA: THAT'S MAJOR. 00:21:13.933 --> 00:21:14.866 DR. BRYAN: IT PREVENTS OUR TELOMERES, 00:21:14.966 --> 00:21:15.933 THE ENDS OF OUR CHROMOSOMES, 00:21:16.033 --> 00:21:19.800 FROM GETTING SHORTER, SO IT EXTENDS LIFE SPAN. 00:21:19.900 --> 00:21:20.833 WHAT ELSE DOES IT DO. 00:21:20.933 --> 00:21:23.000 IT IMPROVES PERFORMANCE, IMPROVES COGNITION. 00:21:23.100 --> 00:21:26.666 WE TALK ABOUT PERFORMANCE, WE TALK ABOUT ATHLETIC PERFORMANCE. 00:21:26.766 --> 00:21:30.333 IT'S A GREAT ERGOGENIC AID IN IMPROVING PERFORMANCE. 00:21:30.433 --> 00:21:32.766 IT'S A COGNITIVE PERFORMANCE BOOSTER. 00:21:32.866 --> 00:21:34.267 IT IMPROVES BLOOD FLOW TO THE BRAIN, 00:21:34.367 --> 00:21:35.966 IMPROVES GLUCOSE UPTAKES. 00:21:36.066 --> 00:21:38.500 WE CAN RECALL MEMORY AND SHARPER MIND. 00:21:38.600 --> 00:21:40.433 AND IT IMPROVES SEXUAL PERFORMANCE. 00:21:40.533 --> 00:21:42.266 IT'S ALL ABOUT IMPROVING BLOOD FLOW 00:21:42.366 --> 00:21:44.500 AND OPTIMIZING HUMAN PERFORMANCE. 00:21:44.600 --> 00:21:45.800 REBECCA: YEAH. 00:21:45.900 --> 00:21:50.533 AND I KNOW FROM JUST MY OWN LITTLE BIT OF RESEARCH AND STUDY 00:21:50.633 --> 00:21:52.933 THAT THE MITOCHONDRIA OF OUR CELLS, 00:21:53.033 --> 00:21:54.199 THE POWER HOUSE OF OUR CELLS, 00:21:54.299 --> 00:21:56.833 IF WE CAN IMPROVE THAT, THAT IMPACTS OUR HEALTH 00:21:56.933 --> 00:21:58.600 ON A HUGE SCALE. 00:21:58.700 --> 00:21:59.600 JUST THAT ONE THING. 00:21:59.700 --> 00:22:00.666 DR. BRYAN: YEAH, LOOK, YEAH, 00:22:00.766 --> 00:22:02.233 IT IS THE -- SO EVERY CHRONIC DISEASE 00:22:02.333 --> 00:22:05.466 ASSOCIATED WITH LOWER NUMBERS OF MITOCHONDRIA PER CELL 00:22:05.566 --> 00:22:08.166 AND WHAT MITOCHONDRIA THERE, THEY'RE INEFFICIENT. 00:22:08.266 --> 00:22:09.133 RIGHT. 00:22:09.233 --> 00:22:10.733 SO THEY GO FROM AN EFFICIENCY OF, SAY, 00:22:10.833 --> 00:22:13.067 36 MILES TO GALLON TO 4 MILES PER GALLON 00:22:13.167 --> 00:22:14.367 OR 2 MILES PER GALLON. 00:22:14.467 --> 00:22:16.133 SO WHAT NITRIC OXIDE DOES IS IT RECOUPLES 00:22:16.233 --> 00:22:18.100 THE ELECTRON TRANSPORT CHAIN, SO IT IMPROVES 00:22:18.200 --> 00:22:21.100 THE EFFICIENCY OF ENERGY PRODUCTION WITHIN THE CELL. 00:22:21.200 --> 00:22:25.033 AND MORE IMPORTANTLY, IT INDUCES MITOCHONDRIAL BIOGENESIS. 00:22:25.133 --> 00:22:26.733 SO IF YOU MAKE SUFFICIENT NITRIC OXIDE, 00:22:26.833 --> 00:22:29.299 IT TELLS THAT CELL, I NEED TO MAKE MORE MITOCHONDRIA, 00:22:29.399 --> 00:22:30.966 SO YOU HAVE MORE MITOCHONDRIA GENERATING 00:22:31.066 --> 00:22:34.099 MORE ENERGY MORE EFFICIENTLY WITH EVEN LESS OXYGEN. 00:22:34.199 --> 00:22:35.800 SO IF YOU CAN MAKE MITOCHONDRIA, 00:22:35.900 --> 00:22:38.733 THEY BECOME UNCOUPLED, YOU HAVE LESS MITOCHONDRIA PER CELL, 00:22:38.833 --> 00:22:41.133 AND IT SETS THE STAGE FOR CHRONIC DISEASE. 00:22:41.233 --> 00:22:43.500 SO WE SEE IN MOST ATHLETES, 00:22:43.600 --> 00:22:46.967 PROFESSIONAL ATHLETES USE OUR NITRIC OXIDE PRODUCT TECHNOLOGY. 00:22:47.067 --> 00:22:47.867 REBECCA: YEAH. 00:22:47.967 --> 00:22:48.600 BECAUSE THEY NEED TO BE FUNCTIONING 00:22:48.700 --> 00:22:49.433 ON AN EVEN HIGHER LEVEL, 00:22:49.533 --> 00:22:50.566 PERFORMANCE-WISE, 00:22:50.666 --> 00:22:52.066 WITH THEIR BODIES. 00:22:52.166 --> 00:23:00.766 SO WHY IS THERE A NITRIC OXIDE DEFICIENCY IN OUR WORLD TODAY? 00:23:00.866 --> 00:23:02.167 DR. BRYAN: IT'S BASICALLY EVERYTHING WE DO 00:23:02.267 --> 00:23:04.400 ON A DAILY BASIS, FROM THE FOODS WE EAT 00:23:04.500 --> 00:23:08.000 TO THE DRUG THERAPY WE TAKE TO THE ORAL HYGIENIC PRACTICES 00:23:08.100 --> 00:23:11.300 THAT WE EMPLOY ALL AROUND US. 00:23:11.400 --> 00:23:14.200 SO WE AND OTHERS HAVE DISCOVERED THAT 00:23:14.300 --> 00:23:16.900 THERE'S BACTERIA THAT LIVE IN THE GRIPS OF THE TONGUE 00:23:17.000 --> 00:23:18.066 AND THE MOUTH THAT ARE RESPONSIBLE 00:23:18.166 --> 00:23:20.399 FOR THE PRODUCTION OF NITRIC OXIDE. 00:23:20.499 --> 00:23:23.899 SO ANYTHING THAT DESTROYS THE MICROBIOME, SUCH AS -- 00:23:23.999 --> 00:23:24.933 REBECCA: OH, WOW. 00:23:25.033 --> 00:23:26.566 SO IT'S CONNECTED TO THE MICROBIOME, AS WELL, 00:23:26.666 --> 00:23:27.466 THE NITRIC OXIDE? 00:23:27.566 --> 00:23:28.633 DR. BRYAN: ABSOLUTELY. 00:23:28.733 --> 00:23:31.866 SO THERE ARE BACTERIA THAT ARE RESPIRE ON NITROGEN 00:23:31.966 --> 00:23:35.699 AND NITRATE AND THEN THEY REDUCE NITRATE TO NITRITE. 00:23:35.799 --> 00:23:37.600 WE SWALLOW IT, AND WHEN IT REACHES THE ENVIRONMENT 00:23:37.700 --> 00:23:40.233 OF OUR STOMACH, IT PRODUCES NITRIC OXIDE GAS. 00:23:40.333 --> 00:23:43.000 AS LONG AS THERE'S SUFFICIENT STOMACH ACID PRODUCTION. 00:23:43.100 --> 00:23:45.966 SO ALL OF THIS IS DEPENDENT UPON GOOD ORAL HYGEINE 00:23:46.066 --> 00:23:48.033 AND A GOOD ORAL MICROBIOME. 00:23:48.133 --> 00:23:49.366 AND THEN WHEN YOU THINK ABOUT, OKAY, 00:23:49.466 --> 00:23:51.400 WHAT'S DISRUPTING THIS? 00:23:51.500 --> 00:23:52.433 FLUORIDE. 00:23:52.533 --> 00:23:54.233 THERE'S FLUORIDE IN MOST TOOTHPASTE. 00:23:54.333 --> 00:23:55.933 REBECCA: AND STILL MOST DENTISTS USE IT. 00:23:56.033 --> 00:23:57.199 DR. BRYAN: AND FLUORIDE RINSES. 00:23:57.299 --> 00:23:59.900 AND THERE'S, IN 73% OF THE MUNICIPALITIES IN THE U.S., 00:24:00.000 --> 00:24:01.733 THERE'S FLUORIDE IN THE DRINKING WATER. 00:24:01.833 --> 00:24:02.966 IT'S NOT JUST THE DRINKING WATER, 00:24:03.066 --> 00:24:04.233 IT'S THE WATER YOU'RE BATHING IN, 00:24:04.333 --> 00:24:06.099 YOU'RE COOKING IN, YOU'RE DRINKING. 00:24:06.199 --> 00:24:08.400 AND SO FLUORIDE IS AN ANTISEPTIC. 00:24:08.500 --> 00:24:11.833 IT'S PUT IN THE WATER TO KILL THE BACTERIA IN THE PIPES. 00:24:11.933 --> 00:24:14.499 SO IT KILLS THE BACTERIA IN OUR PIPES, RIGHT. 00:24:14.599 --> 00:24:16.699 IN OUR GUT, IN OUR MOUTH. 00:24:16.799 --> 00:24:18.299 THERE'S A MICROBIOME ON OUR SKIN, 00:24:18.399 --> 00:24:19.666 IT'S KILLING THE GOOD BACTERIA ON THE SKIN, 00:24:19.766 --> 00:24:24.433 CAUSING ACNE, FUNGAL OVERGROWTH, DERMATITIS. 00:24:24.533 --> 00:24:27.466 SO WE HAVE TO SUPPORT THE MICROBIOME AND NOT DESTROY IT. 00:24:27.566 --> 00:24:29.733 SO FLUORIDE IS A BAD ACTOR. 00:24:29.833 --> 00:24:31.067 AND WE HAVE TO GET RID OF IT. 00:24:31.167 --> 00:24:33.767 I THINK WE'RE ON THE RIGHT PATH TO GETTING RID OF FLOURIDE. 00:24:33.867 --> 00:24:36.800 AND IT LOWERS IQ IN KIDS BY AS MUCH AS 7 POINTS. 00:24:36.900 --> 00:24:37.733 REBECCA: YEAH. 00:24:37.833 --> 00:24:39.100 THAT'S CRAZY. 00:24:39.200 --> 00:24:41.200 DR. BRYAN: AND THEN THE OTHER THING IS ANTISEPTIC MOUTH WASH. 00:24:41.300 --> 00:24:42.933 TWO OF OUT THREE AMERICANS WAKE UP EVERY MORNING 00:24:43.033 --> 00:24:46.433 AND USE MOUTH WASH, KILLING THE ENTIRE MICROBIOME. 00:24:46.533 --> 00:24:47.800 AND NOT COINCIDENTALLY TWO OUT OF THREE AMERICANS 00:24:47.900 --> 00:24:50.466 HAVE AN UNSAFE ELEVATION IN BLOOD PRESSURE. 00:24:50.566 --> 00:24:52.200 SO WE'VE DONE CONTROLLED STUDIES WHERE WE TAKE 00:24:52.300 --> 00:24:55.066 PEOPLE WITH NORMAL BLOOD PRESSURE AND WE JUST GIVE THEM 00:24:55.166 --> 00:24:56.999 MOUTH WASH FOR SEVEN DAYS 00:24:57.099 --> 00:24:59.900 AND WE SEE THEIR BLOOD PRESSURE GO UP. 00:25:00.000 --> 00:25:01.500 JUST BY KILLING THE MICROBIOME, 00:25:01.600 --> 00:25:03.900 WE CAN SEE AN INCREASE IN BLOOD PRESSURE. 00:25:04.000 --> 00:25:06.033 NOW, THINK ABOUT THE GLOBAL IMPACT OF THIS. 00:25:06.133 --> 00:25:07.999 HIGH BLOOD PRESSURE'S THE NUMBER ONE DRIVER 00:25:08.099 --> 00:25:09.700 FOR THE NUMBER ONE KILLER OF MEN AND WOMEN: 00:25:09.800 --> 00:25:11.199 CARDIOVASCULAR DISEASE. 00:25:11.299 --> 00:25:14.700 AND 50% OF THE PEOPLE WHO TAKE PRESCRIPTION MEDICATIONS 00:25:14.800 --> 00:25:15.700 TO MANAGE YOUR BLOOD PRESSURE 00:25:15.800 --> 00:25:18.099 DON'T RESPOND WITH BETTER BLOOD PRESSURE. 00:25:18.199 --> 00:25:19.733 CALL THAT RESISTIVE HYPERTENSION. 00:25:19.833 --> 00:25:20.733 REBECCA: REALLY? 00:25:20.833 --> 00:25:21.833 DR. BRYAN: THEY'RE RESISTANT TO THERAPY. 00:25:21.933 --> 00:25:22.400 REBECCA: [ GASPS ] 00:25:22.500 --> 00:25:23.233 I DIDN'T KNOW THAT. 00:25:23.333 --> 00:25:24.399 DR. BRYAN: YEAH. 00:25:24.499 --> 00:25:25.600 REBECCA: I KNEW THAT THE NUMBER ONE PRESCRIPTION DRUG 00:25:25.700 --> 00:25:28.700 THAT PEOPLE TAKE IS CONNECTED TO BLOOD PRESSURE, 00:25:28.800 --> 00:25:30.167 THAT'S RIGHT, RIGHT? 00:25:30.267 --> 00:25:31.333 DR. BRYAN: WELL, 00:25:31.433 --> 00:25:33.567 THE NUMBER ONE IS A CHOLESTEROL-LOWERING MEDICATION. 00:25:33.667 --> 00:25:35.366 BUT NOW, THESE DRUGS ARE RESISTANT -- 00:25:35.466 --> 00:25:36.700 THESE PEOPLE ARE RESISTANT TO DRUG THERAPY 00:25:36.800 --> 00:25:38.833 BECAUSE IT'S THE WRONG TARGET. 00:25:38.933 --> 00:25:40.833 THE DRUGS THAT ARE TREATED FOR HYPERTENSION 00:25:40.933 --> 00:25:41.833 ARE USUALLY ACE INHIBITORS, 00:25:41.933 --> 00:25:44.033 WHICH ARE AN INTERSENSORY CONVERTING ENZYME, 00:25:44.133 --> 00:25:46.200 ARB'S, AN INTERSENSORY RECEPTOR BLOCKERS, 00:25:46.300 --> 00:25:47.733 CALCIUM CHANNEL BLOCKERS, 00:25:47.833 --> 00:25:50.600 OR DIURETICS TO MOBILIZE FLUID OR WORST CASE, 00:25:50.700 --> 00:25:52.133 BETA BLOCKER TO PACE THE HEART. 00:25:52.233 --> 00:25:54.100 BUT YET PEOPLE DON'T RESPOND WITH BETTER BLOOD PRESSURE. 00:25:54.200 --> 00:25:57.066 BECAUSE WHAT WE'RE FINDING IS THEIR HYPERTENSION 00:25:57.166 --> 00:26:00.500 IS A SYMPTOM OF ORAL DYSBIOSIS AND LACK OF NITRIC OXIDE. 00:26:00.600 --> 00:26:01.800 REBECCA: WOW. 00:26:01.900 --> 00:26:04.833 DR. BRYAN: SO NOW, YOU HAVE A CONVERSATION WITH A PATIENT 00:26:04.933 --> 00:26:06.200 AND PHYSICIAN, AND GO, OKAY, 00:26:06.300 --> 00:26:09.300 YOU'RE RESISTANT TO ACE INHIBITORS, ARB'S, 00:26:09.400 --> 00:26:10.400 CALCIUM CHANNEL BLOCKERS. 00:26:10.500 --> 00:26:12.400 DO YOU USE A FLUORIDE IN YOUR TOOTHPASTE? 00:26:12.500 --> 00:26:13.000 YES. 00:26:13.100 --> 00:26:13.800 DO YOU USE MOUTH WASH? 00:26:13.900 --> 00:26:14.899 YES. 00:26:14.999 --> 00:26:15.800 OKAY. 00:26:15.900 --> 00:26:17.200 STOP USING MOUTH WASH. 00:26:17.300 --> 00:26:19.167 GET RID OF FLUORIDE IN YOUR TOOTHPASTE. 00:26:19.267 --> 00:26:22.633 COME BACK 30 DAYS LATER, AND LET'S CHECK YOUR BLOOD PRESSURE. 00:26:22.733 --> 00:26:24.699 AND REMARKABLY, THEIR BLOOD PRESSURE COMES DOWN. 00:26:24.799 --> 00:26:27.466 SO IF WE STOP KILLING THE NITRIC OXIDE-PRODUCING BACTERIA 00:26:27.566 --> 00:26:29.233 IN THE MOUTH AND WE SUPPORT IT, 00:26:29.333 --> 00:26:33.167 WE REPOPULATE AND RESTORE THESE FLORA, 00:26:33.267 --> 00:26:36.700 THESE BACTERIA, THEN OUR BLOOD PRESSURE CAN BECOME NORMAL. 00:26:36.800 --> 00:26:40.200 AND ON A GLOBAL SCALE, IF WE CAN MANAGE BLOOD PRESSURE, 00:26:40.300 --> 00:26:42.133 BECAUSE EVERY 1 MILLIMETER OF MERCURY 00:26:42.233 --> 00:26:44.900 OF INCREASE IN BLOOD PRESSURE INCREASES YOUR RISK 00:26:45.000 --> 00:26:47.733 OF CARDIOVASCULAR DISEASE BY 1%. 00:26:47.833 --> 00:26:49.599 SO IF YOU'VE GOT A BLOOD PRESSURE OF 140/90, 00:26:49.699 --> 00:26:53.566 YOU HAVE A 20% GREATER RISK -- OR 20% GREATER RISK 00:26:53.666 --> 00:26:56.400 OF DEVELOPING CARDIOVASCULAR DISEASE. 00:26:56.500 --> 00:26:58.067 SO THIS IS THE TARGET. 00:26:58.167 --> 00:27:00.067 THE MICROBIOME IS THE TARGET. 00:27:00.167 --> 00:27:02.633 AND THAT'S WHAT WE'RE FOCUSED ON IN RESTORING THE PRODUCTION, 00:27:02.733 --> 00:27:05.100 NATURAL PRODUCTION OF NITRIC OXIDE. 00:27:05.200 --> 00:27:08.367 REBECCA: AND YOU'RE WORKING ON A MOUTH WASH; 00:27:08.467 --> 00:27:09.400 AM I CORRECT? 00:27:09.500 --> 00:27:10.266 DR. BRYAN: WE JUST LAUNCHED A TOOTH PASTE, 00:27:10.366 --> 00:27:11.399 BECAUSE I'VE STRUGGLED FOR YEARS. 00:27:11.499 --> 00:27:14.367 NUMBER ONE, THERE ARE SOME FLUORIDE-FREE TOOTHPASTES 00:27:14.467 --> 00:27:15.633 OUT THERE THAT I'VE BEEN USING, 00:27:15.733 --> 00:27:18.833 BUT THERE ARE OTHER THINGS IN THERE THAT I DIDN'T LIKE, 00:27:18.933 --> 00:27:21.933 BUT IT'S THE BEST OUT THERE. 00:27:22.033 --> 00:27:23.400 SO I THOUGHT, OKAY, NOW THAT WE UNDERSTAND 00:27:23.500 --> 00:27:25.733 THE ECOLOGY OF THE ORAL MICROBIOME, 00:27:25.833 --> 00:27:26.966 I'M GOING TO DEVELOP A TOOTHPASTE, NUMBER ONE, 00:27:27.066 --> 00:27:29.267 THAT'S FREE OF FLUORIDE, BUT NUMBER TWO, 00:27:29.367 --> 00:27:30.800 REMINERALIZES THE TEETH -- 00:27:30.900 --> 00:27:32.233 REBECCA: YES, BECAUSE THAT'S THE OTHER THING YOU NEED. 00:27:32.333 --> 00:27:35.066 DR. BRYAN: AND THEN SUPPORTS THE HEALTHY MICROBIOME. 00:27:35.166 --> 00:27:37.033 AND SO THAT WAS PROBABLY A FIVE-YEAR PROJECT. 00:27:37.133 --> 00:27:39.167 WE LAUNCHED A TOOTHPASTE A COUPLE OF MONTHS AGO. 00:27:39.267 --> 00:27:40.466 REBECCA: I'M SO EXCITED. 00:27:40.566 --> 00:27:41.667 DR. BRYAN: IT'S INCREDIBLE. 00:27:41.767 --> 00:27:42.566 WE'RE STARTING TO SEE PEOPLE'S BLOOD PRESSURE COME DOWN 00:27:42.666 --> 00:27:45.767 JUST BY SWITCHING TO OUR TOOTHPASTE. 00:27:45.867 --> 00:27:47.200 AND THEN WE'RE ALSO LAUNCHING 00:27:47.300 --> 00:27:51.267 A MICROBIOME-SPECIFIC MOUTH RINSE. 00:27:51.367 --> 00:27:54.533 SO AGAIN, ONE THAT WILL KILL THE PATHOGENIC BACTERIA, 00:27:54.633 --> 00:27:57.866 BUT SUPPORTS THE NORMAL NON-PATHOGENIC COMMENSAL BACTERIA. 00:27:57.966 --> 00:27:59.367 SO AGAIN, TARGETING THE MICROBIOME, 00:27:59.467 --> 00:28:01.300 SUPPORTING THE MICROBIOME. 00:28:01.400 --> 00:28:02.599 IT'LL BE A GAME-CHANGER. 00:28:02.699 --> 00:28:05.133 REBECCA: Y'ALL, I'M SO EXCITED FOR THIS BECAUSE I LIKE -- 00:28:05.233 --> 00:28:06.367 I'M GOING TO LIKE GEEK OUT OVER ALL THIS STUFF, 00:28:06.467 --> 00:28:07.933 AND THIS IS LIKE THE KIND OF PRODUCTS 00:28:08.033 --> 00:28:11.200 THAT I'VE BEEN LOOKING FOR, SO I AM SO EXCITED BECAUSE, 00:28:11.300 --> 00:28:14.799 YES, A LOT OF PEOPLE UNDERSTAND KIND OF ABOUT 00:28:14.899 --> 00:28:17.333 HOW IMPORTANT THE MICROBIOME IN OUR GUT IS, 00:28:17.433 --> 00:28:20.900 BUT PEOPLE DON'T UNDERSTAND THE MICROBIOME IN THE MOUTH 00:28:21.000 --> 00:28:21.666 AND HOW -- 00:28:21.766 --> 00:28:22.466 DR. BRYAN: OR ON OUR SKIN. 00:28:22.599 --> 00:28:25.067 PEOPLE THAT HAVE POOR SKIN HEALTH. 00:28:25.167 --> 00:28:28.799 AND PEOPLE TAKING MULTIPLE BATHS A DAY WITH ANTISEPTIC SOAPS 00:28:28.899 --> 00:28:30.133 AND RINSING OFF THE BACTERIA 00:28:30.233 --> 00:28:32.466 AND IT'S CAUSING DYSBIOSIS. 00:28:32.566 --> 00:28:33.699 AND THEY DEVELOP BODY ODOR, 00:28:33.799 --> 00:28:35.067 THEN THESE ANTIPERSPIRANTS DEODORANTS, 00:28:35.167 --> 00:28:36.533 WHICH CONTAIN ALUMINUM AND TOXINS, 00:28:36.633 --> 00:28:39.267 AND IT'S JUST THIS VICIOUS CYCLE. 00:28:39.367 --> 00:28:40.600 REBECCA: OH, NO! 00:28:40.700 --> 00:28:43.599 THE ALUMINUM IS -- I KNEW THE ALUMINUM WAS BAD FOR YOUR BODY 00:28:43.699 --> 00:28:44.467 BECAUSE IT'S A TOXIN, 00:28:44.567 --> 00:28:47.367 BUT IT ALSO IS BAD FOR THE BACTERIA? 00:28:47.467 --> 00:28:48.100 DR. BRYAN: FOR THE BACTERIA, YEAH. 00:28:48.200 --> 00:28:48.600 REBECCA: 00:28:48.700 --> 00:28:49.233 [ GASPS ] 00:28:49.333 --> 00:28:49.867 OH, NO! 00:28:49.967 --> 00:28:51.000 ARE YOU MAKING DEODORANT? 00:28:51.100 --> 00:28:51.766 DR. BRYAN: WE'RE WORKING ON THAT. 00:28:51.866 --> 00:28:52.966 BECAUSE HERE'S THE PROBLEM. 00:28:53.066 --> 00:28:54.066 REBECCA: OH, THANK GOD, BECAUSE THAT'S ANOTHER ONE. 00:28:54.166 --> 00:28:55.033 DR. BRYAN: SMELL OCCURS, 00:28:55.133 --> 00:28:56.966 WHETHER IT'S BAD BREATH, BAD ARMPITS, 00:28:57.066 --> 00:28:59.633 OR SMELLY POOP, IT'S ALL FROM THE BACTERIA. 00:28:59.733 --> 00:29:01.100 IT'S DYSBIOSIS. 00:29:01.200 --> 00:29:02.666 SO IF YOUR ARMPITS SMELL, 00:29:02.766 --> 00:29:04.000 IT MEANS YOU'VE GOT A BACTERIAL PROBLEM. 00:29:04.100 --> 00:29:05.699 YOU'VE GOT AN IMBALANCE IN DYSBIOSIS. 00:29:05.799 --> 00:29:08.566 IF YOUR BREATH STINKS, YOU'VE GOT DYSBIOSIS. 00:29:08.666 --> 00:29:10.767 SO WHAT WE TRIED TO DO, RATHER THAN KILLING EVERYTHING 00:29:10.867 --> 00:29:12.700 AND THROWING AN ATOMIC BOMB IN THERE, 00:29:12.800 --> 00:29:16.267 LET'S SELECTIVELY KILL THE ODOR CAUSING THE PATHOGENIC BACTERIA 00:29:16.367 --> 00:29:18.766 AND LET'S SUPPORT THE NON-PATHOGENIC COMMENSALS. 00:29:18.866 --> 00:29:20.166 I HAVEN'T WORN DEODORANT IN 00:29:20.266 --> 00:29:22.833 MORE THAN 20 YEARS, BUT YET I DON'T HAVE BODY ODOR. 00:29:22.933 --> 00:29:26.467 I DON'T PUT THOSE ON ME BECAUSE I SUPPORT MY MICROBIOME. 00:29:26.567 --> 00:29:27.533 I DON'T DESTROY IT. 00:29:27.633 --> 00:29:30.300 REBECCA: WHAT DO YOU DO FOR YOUR MICROBIOME? 00:29:30.400 --> 00:29:33.433 DR. BRYAN: UM, WELL, TYPICALLY NUMBER ONE, 00:29:33.533 --> 00:29:34.933 I DON'T USE ANY TOXINS. 00:29:35.033 --> 00:29:36.900 SO I DON'T USE ANY LOTIONS OR 00:29:37.000 --> 00:29:40.100 ANY ANTIDEPRESSANT OR DEODORANT, UM. 00:29:40.200 --> 00:29:41.966 AND I HAVE A HOME FILTRATION SYSTEM. 00:29:42.066 --> 00:29:45.433 SO I'M NOT MAKING MY BODY ANTISEPTIC WITH FLUORIDE 00:29:45.533 --> 00:29:48.766 WHAT I BATHE IN OR DRINK OR COOK IN, 00:29:48.866 --> 00:29:50.433 BUT I TAKE NITRIC OXIDE AND I TRY TO EAT 00:29:50.533 --> 00:29:52.200 A GOOD CLEAN DIET. 00:29:52.300 --> 00:29:53.300 AND I'M EXPOSED TO SUNLIGHT 00:29:53.400 --> 00:29:55.267 AT LEAST 20 TO 30 MINUTES A DAY FULL, 00:29:55.367 --> 00:29:57.600 FULL BODY EXPOSURE AND THAT HELPS KIND OF 00:29:57.700 --> 00:30:00.533 REPOPULATE AND CREATE BALANCE IN THE MICROBIOME. 00:30:00.633 --> 00:30:01.566 REBECCA: REALLY? 00:30:01.666 --> 00:30:03.033 I DIDN'T KNOW I KNOW HOW IMPORTANT SUNLIGHT 00:30:03.133 --> 00:30:04.867 EXPOSURE IS, BUT I DIDN'T KNOW ABOUT THE CONNECTION 00:30:04.967 --> 00:30:05.833 TO YOUR MICROBIOME. 00:30:05.933 --> 00:30:07.033 DR. BRYAN: OH, YEAH. 00:30:07.133 --> 00:30:08.466 REBECCA: DO YOU TRY TO DO IT AT A CERTAIN TIME OF DAY? 00:30:08.566 --> 00:30:09.633 DR. BRYAN: FOR SUNLIGHT IN THE MORNING. 00:30:09.733 --> 00:30:10.866 REBECCA: THAT'S WHAT EVERYONE SAYS. 00:30:10.966 --> 00:30:13.000 THEY SAY IT'S THE BEST SUNLIGHT. 00:30:13.100 --> 00:30:14.000 DR. BRYAN: NO, IT IS. 00:30:14.100 --> 00:30:15.366 IT COMPLETELY RESETS YOUR CIRCADIAN RHYTHM. 00:30:15.466 --> 00:30:16.500 SO WHAT I DO WHEN I WAKE UP, 00:30:16.600 --> 00:30:17.599 I WAKE UP, YOU KNOW. 00:30:17.699 --> 00:30:19.133 USUALLY AN HOUR BEFORE THE SUN COMES UP. 00:30:19.233 --> 00:30:22.433 I SIT IN A SAUNA FOR 30 MINUTES IN 170 DEGREES. 00:30:22.533 --> 00:30:23.300 AND THERE, 00:30:23.400 --> 00:30:24.200 I'M DOING MY PRAYERS. 00:30:24.300 --> 00:30:25.067 I OPEN MY HALLOW APP. 00:30:25.167 --> 00:30:28.233 AND I JUST I GIVE GRATITUDE, I PRAY 00:30:28.333 --> 00:30:31.100 AND REALLY THAT'S HOW I START MY DAY WITH GRATITUDE 00:30:31.200 --> 00:30:32.033 AND JUST I HAVE A -- 00:30:32.133 --> 00:30:34.233 EVERY DAY I WAKE UP I HAVE A PLAN. 00:30:34.333 --> 00:30:35.233 AND THE PLAN IS NUMBER ONE, 00:30:35.333 --> 00:30:37.233 HOW DO I BE BETTER THAN I WAS YESTERDAY? 00:30:37.333 --> 00:30:38.033 AND THEN HOW DO I -- 00:30:38.133 --> 00:30:38.666 HOW AM I GOING TO EXECUTE THIS 00:30:38.766 --> 00:30:40.667 STRATEGY HOUR BY HOUR? 00:30:40.767 --> 00:30:41.533 AND THAT GETS MY MIND MENTALLY 00:30:41.633 --> 00:30:43.233 PREPARED FOR THE DAY. 00:30:43.333 --> 00:30:45.200 AND THEN AFTER 30 MINUTES OF SAUNA, 00:30:45.300 --> 00:30:47.633 I'LL TYPICALLY A COUPLE DAYS A WEEK GO DO A COLD PLUNGE. 00:30:47.733 --> 00:30:49.933 GET IN A NICE BATH FOR THREE MINUTES. 00:30:50.033 --> 00:30:51.533 AND THEN I'LL GO SIT OUT IN MY FRONT YARD 00:30:51.633 --> 00:30:53.066 AND WATCH THE SUN COME UP 00:30:53.166 --> 00:30:55.033 AND GET THAT FIRST SUNLIGHT, 00:30:55.133 --> 00:30:56.367 USUALLY 20 OR 30 MINUTES. 00:30:56.467 --> 00:30:57.433 REBECCA: AND YOU LOOK INTO THE -- 00:30:57.533 --> 00:30:58.533 DR. BRYAN: LOOK INTO THE SUN. 00:30:58.633 --> 00:30:59.900 REBECCA: BECAUSE THERE'S SOMETHING ABOUT THAT TOO. 00:31:00.000 --> 00:31:02.066 DR. BRYAN: YEAH, IT RESETS YOUR, YOUR CIRCADIAN RHYTHM. 00:31:02.166 --> 00:31:05.233 IT'S ACTIVATING A LOT OF PATHWAYS IN THE EYE THAT 00:31:05.333 --> 00:31:07.900 GETS THE EYE READY AND RECEPTIVE FOR -- 00:31:08.000 --> 00:31:09.066 THE WORST THING YOU CAN 00:31:09.166 --> 00:31:10.966 DO IS WEAR, WEAR SUNGLASSES AND I USED 00:31:11.066 --> 00:31:12.333 TO WEAR SUNGLASSES ALL THE TIME. 00:31:12.433 --> 00:31:13.433 REBECCA: ME TOO. 00:31:13.533 --> 00:31:14.599 DR. BRYAN: AND IT AFFECTED MY SLEEP PATTERN. 00:31:14.699 --> 00:31:16.300 I WAS A POOR SLEEPER AND YOU CAN'T HEAL 00:31:16.400 --> 00:31:17.933 WITHOUT PROPER SLEEP. 00:31:18.033 --> 00:31:19.200 REBECCA: THAT'S CRAZY. 00:31:19.300 --> 00:31:21.133 AND THEN THE SCREENS AT NIGHT. 00:31:21.233 --> 00:31:21.866 THAT'S THE OTHER THING THAT MESSES 00:31:21.966 --> 00:31:23.333 WITH YOUR CIRCADIAN RHYTHM. 00:31:23.433 --> 00:31:25.066 DR. BRYAN: YEAH, SO AT NIGHT WHEN THE SUN GOES DOWN, 00:31:25.166 --> 00:31:26.133 I WEAR THE BLUE BLOCKER GLASSES. 00:31:26.200 --> 00:31:27.133 REBECCA: I NEED TO GET SOME OF THOSE. 00:31:27.233 --> 00:31:28.166 DR. BRYAN: TO KEEP THE ARTIFICAL LIGHT OFF. 00:31:28.266 --> 00:31:29.499 REBECCA: BUT THEY'RE NOT ALL EQUAL, RIGHT? 00:31:29.599 --> 00:31:30.533 SOME ARE BETTER THAN OTHERS. 00:31:30.633 --> 00:31:31.399 DR. BRAYN: IT'S LIKE ANY PRODUCT OUT THERE. 00:31:31.499 --> 00:31:32.233 YOU'VE GOT SOME REALLY GOOD 00:31:32.333 --> 00:31:33.566 BRANDS THAT ACTUALLY DO STUFF AND 00:31:33.666 --> 00:31:34.633 YOU'VE GOT THESE, 00:31:34.733 --> 00:31:36.467 UM, WANNA BE COMPANIES WHO ARE JUST SELLING YOU 00:31:36.567 --> 00:31:37.533 A BILL OF GOODS. 00:31:37.633 --> 00:31:39.033 REBECCA: AND THERE'S OTHER NITRIC -- 00:31:39.133 --> 00:31:42.266 IS THERE OTHER NITRIC OXIDE PEOPLE? 00:31:42.366 --> 00:31:43.867 DR. BRYAN: NOW LOOK THERE'S HUNDREDS OF COMPANIES OUT 00:31:43.967 --> 00:31:46.599 THERE SELLING HUNDREDS OF SO-CALLED NITRIC OXIDE 00:31:46.699 --> 00:31:49.233 PRODUCTS AND THAT'S MY GREATEST CHALLENGE... 00:31:49.333 --> 00:31:50.166 REBECCA: YEAH. 00:31:50.266 --> 00:31:51.100 DR. BRYAN: EVERY DAY WHEN I WAKE UP, 00:31:51.200 --> 00:31:53.300 IT'S HOW DO WE DIFFERENTIATE WHAT WE DO 00:31:53.400 --> 00:31:55.633 FROM ALL THESE OTHER WANNABES OUT THERE. 00:31:55.733 --> 00:32:00.100 BECAUSE WHAT I'VE DONE IS SPENT 25 YEARS IN THE TRENCHES, IN 00:32:00.200 --> 00:32:02.900 THE RESEARCH LAB, UNDERSTANDING THE BIOCHEMISTRY 00:32:03.000 --> 00:32:04.666 AND ENTOMOLOGY TO WHERE I HAVE 00:32:04.766 --> 00:32:06.966 AN UNDERSTANDING WHERE I CAN MAKE PRODUCTS. 00:32:07.066 --> 00:32:08.267 ALL THESE OTHER COMPANIES OUT THERE 00:32:08.367 --> 00:32:11.833 ARE KIND OF, YOU KNOW, FOLLOWING THE FAD? 00:32:11.933 --> 00:32:12.900 REBECCA: YEAH. 00:32:13.000 --> 00:32:13.800 DR. BRYAN: THEY'RE CREATING A MARKET FOR IT 00:32:13.900 --> 00:32:15.700 AND THEY WANT TO PROFIT OFF THOSE -- 00:32:15.800 --> 00:32:17.233 THAT GROWING MARKET. 00:32:17.333 --> 00:32:19.266 SO THERE'S HUNDREDS OF PRODUCTS OUT THERE, 00:32:19.366 --> 00:32:20.800 BUT THE PROBLEM IS MOST OF THEM DON'T WORK. 00:32:20.900 --> 00:32:21.800 AND I TEST THESE PRODUCTS. 00:32:21.900 --> 00:32:23.300 I HAVE A NITRIC OXIDE ANALYZER. 00:32:23.400 --> 00:32:25.466 I CAN TELL YOU IF IT'S WORKING OR NOT 00:32:25.566 --> 00:32:27.167 AND NONE OF THEM WORK. 00:32:27.267 --> 00:32:28.400 REBECCA: YEAH. 00:32:28.500 --> 00:32:30.300 DR. BRYAN: THEY GIVE YOUR BODY PRECURSORS AND SUBSTRATES 00:32:30.400 --> 00:32:31.700 AND HOPING YOUR BODY CAN CONVERT IT, 00:32:31.800 --> 00:32:33.466 BUT THE REASON PEOPLE ARE NITRIC OXIDE DEFICIENT IS 00:32:33.566 --> 00:32:37.667 THE ENDOGENOUS SYSTEMS FOR UTILIZING THAT IS BROKEN. 00:32:37.767 --> 00:32:40.100 SO YOU JUST MAKE EXPENSIVE URINE. 00:32:40.200 --> 00:32:41.100 REBECCA: YOU'RE JUST PEEING IT OUT. 00:32:41.200 --> 00:32:42.266 DR. BRYAN: YOU'RE JUST PEEING IT OUT, YEAH. 00:32:42.366 --> 00:32:44.299 AND SO WHAT I TRY TO DO IS NUMBER ONE, 00:32:44.399 --> 00:32:46.700 EDUCATE, INFORM ON THE SCIENCE OF NITRIC OXIDE. 00:32:46.800 --> 00:32:47.566 REBECCA: YEAH. 00:32:47.666 --> 00:32:48.933 DR. BRYAN: HOPEFULLY BUILD TRUST 00:32:49.033 --> 00:32:49.800 BECAUSE I'VE BEEN THERE. 00:32:49.900 --> 00:32:51.533 I UNDERSTAND THE SCIENCE 00:32:51.633 --> 00:32:53.600 AND THAT WHAT I DO WE VALIDATE OUR PRODUCTS. 00:32:53.700 --> 00:32:54.767 WE SHOW YOU HOW THEY WORK. 00:32:54.867 --> 00:32:57.233 YOU CAN SEE THEM WORKING RIGHT BEFORE YOUR EYES. 00:32:57.333 --> 00:32:58.933 AND, YOU KNOW, OTHER COMPANIES, COMPETITIVE 00:32:59.033 --> 00:33:00.733 COMPANIES DON'T LIKE THAT. 00:33:00.833 --> 00:33:02.700 AND WHEN I SHOW THE TRUTH 00:33:02.800 --> 00:33:04.566 AND SHOW THEIR PRODUCTS DON'T WORK, 00:33:04.666 --> 00:33:08.266 I GET SUED OR THEY COMPLAIN TO, UH, 00:33:08.366 --> 00:33:10.566 ORGANIZERS AT MEDICAL MEETINGS THAT I CAN'T TEST 00:33:10.666 --> 00:33:11.366 THEIR PRODUCTS ANYMORE. 00:33:11.466 --> 00:33:13.133 BECAUSE IT, IT REVEALS 00:33:13.233 --> 00:33:16.966 THE TRUTH THAT THEIR PRODUCTS ARE, ARE NOT EFFECTIVE 00:33:17.066 --> 00:33:18.466 AND REALLY FRAUDULENT. 00:33:18.566 --> 00:33:19.166 IT'S -- AT THE END OF THE DAY, 00:33:19.266 --> 00:33:20.899 IT'S FRAUD. 00:33:20.999 --> 00:33:22.100 REBECCA: WELL, I'M GLAD WE'RE OUT HERE 00:33:22.200 --> 00:33:23.600 SPREADING THE TRUTH. 00:33:23.700 --> 00:33:24.833 ANOTHER THING THAT YOU 00:33:24.933 --> 00:33:28.700 SAID THAT TAKES OUT NITRIC OXIDE, DEPLETES US IS SUGAR. 00:33:28.800 --> 00:33:29.966 YOU TALK ABOUT THAT. 00:33:30.066 --> 00:33:31.433 DR. BRYAN: SUGAR, SUGAR IS THE POISON. 00:33:31.533 --> 00:33:32.200 IT'S THE TOXIN. 00:33:32.300 --> 00:33:33.233 IT'S THE ENEMY. 00:33:33.333 --> 00:33:34.399 REBECCA: BUT EVERY ONE SAYS, YOU'RE LIKE -- 00:33:34.499 --> 00:33:36.600 I'VE HEARD THIS FROM SO MANY GUESTS AND I'M LIKE I 00:33:36.700 --> 00:33:38.300 DON'T KNOW WHO INVENTED THIS AND PUT IT IN ALL OF 00:33:38.400 --> 00:33:40.366 OUR STUFF BECAUSE IT'S IN EVERYTHING. 00:33:40.466 --> 00:33:41.333 DR. BRYAN: WELL, IT'S ADDICTIVE. 00:33:41.433 --> 00:33:42.166 I MEAN, IT'S MORE -- 00:33:42.266 --> 00:33:42.833 SOME PEOPLE SAY IT'S MORE 00:33:42.933 --> 00:33:44.366 ADDICTIVE THAN COCAINE. 00:33:44.466 --> 00:33:45.600 OR SO IT GETS PEOPLE -- 00:33:45.700 --> 00:33:48.133 AGAIN, IT'S A GREAT FINANCIAL MODEL BECAUSE IT GETS 00:33:48.233 --> 00:33:50.966 PEOPLE HOOKED ON A PRODUCT. 00:33:51.066 --> 00:33:51.900 REBECCA: AND DEPLETED. 00:33:52.000 --> 00:33:53.066 DR. BRYAN: AND DEPLETED. 00:33:53.166 --> 00:33:54.999 AND SO IF YOU'RE, IF YOU'RE ON A HIGH SUGAR DIET, 00:33:55.099 --> 00:33:56.133 YOU'RE GOING TO BE DEPENDENT UPON 00:33:56.233 --> 00:33:59.266 PHARMACEUTICALS AND NOW BIG, BIG AG, BIG PHARMA, 00:33:59.366 --> 00:34:01.133 BIG FOOD IS, YOU KNOW, 00:34:01.233 --> 00:34:04.400 IT'S A COLLUSION TO SHARE IN THE PROFITS. 00:34:04.500 --> 00:34:06.167 REBECCA: I KNOW AND IT MAKES FOOD MORE ADDICTIVE. 00:34:06.267 --> 00:34:07.133 SO YOU EAT MORE. 00:34:07.233 --> 00:34:07.866 DR. BRYAN: IT MAKES FOOD MORE ADDICTIVE. 00:34:07.966 --> 00:34:08.666 REBECCA: YOU GET MORE SICK. 00:34:08.766 --> 00:34:09.933 ONE OF THE BIGGEST THINGS I SAW, 00:34:10.033 --> 00:34:12.067 SO I'VE ACTUALLY CUT DOWN SUGAR 00:34:12.167 --> 00:34:13.366 AS MUCH AS POSSIBLE. 00:34:13.466 --> 00:34:15.266 I REALLY LIKE, IF ANYTHING HAS CANE SUGAR, 00:34:15.366 --> 00:34:15.900 WHICH Y'ALL 00:34:16.000 --> 00:34:16.800 IT'S LIKE IN EVERYTHING. 00:34:16.900 --> 00:34:18.366 LIKE I DON'T THINK PEOPLE REALIZE -- 00:34:18.466 --> 00:34:19.566 DR. BRYAN: IT'S HARD TO AVOID. 00:34:19.666 --> 00:34:20.967 REBECCA: LIKE PEOPLE THINK IT'S JUST LIKE SWEETS. 00:34:21.067 --> 00:34:21.900 IT'S IN LIKE DRINKS. 00:34:22.000 --> 00:34:22.967 IT'S IN SAUCES. 00:34:23.067 --> 00:34:24.000 IT'S IN, 00:34:24.100 --> 00:34:25.866 I MEAN, ALMOST ANY KIND OF PROCESSED FOOD. 00:34:25.966 --> 00:34:26.700 DR. BRYAN: SALAD DRESSINGS. 00:34:26.800 --> 00:34:27.200 REBECCA: YEAH. 00:34:27.300 --> 00:34:28.033 IT HAS SUGAR. 00:34:28.133 --> 00:34:29.133 AND IF YOU GO OUT TO EAT, 00:34:29.233 --> 00:34:31.866 IT'S BECAUSE IT'S A CHEAP WAY TO MAKE FOOD MORE, 00:34:31.966 --> 00:34:34.900 YOU KNOW, ADDICTIVE AND LIKE FOR PEOPLE TO EAT. 00:34:35.000 --> 00:34:36.566 BUT ALL THAT BEING SAID, 00:34:36.666 --> 00:34:37.800 I MAJORLY CUT DOWN ON IT. 00:34:37.900 --> 00:34:38.533 AND ONE OF THE FIRST THINGS 00:34:38.633 --> 00:34:40.700 I SAW IS HOW MUCH BETTER 00:34:40.800 --> 00:34:43.366 MY IMMUNE SYSTEM WAS, AND I WASN'T GETTING -- 00:34:43.466 --> 00:34:44.233 I DON'T GET SICK. 00:34:44.333 --> 00:34:45.900 I WAS GETTING SICK ALL THE TIME, 00:34:46.000 --> 00:34:47.267 BECAUSE I HAVE LITTLE KIDS. 00:34:47.367 --> 00:34:48.999 AND I WAS LIKE I CAN'T BE SICK. 00:34:49.099 --> 00:34:50.733 THAT WAS, THAT'S ONE OF MY BIGGEST MOTIVATORS 00:34:50.833 --> 00:34:52.033 TO STAY AWAY FROM IT. 00:34:52.133 --> 00:34:54.333 AND IT MAKES ME, IT CAUSES INFLAMMATION. 00:34:54.433 --> 00:34:56.033 SO IT MAKES ME FEEL BAD. 00:34:56.133 --> 00:34:57.466 IF I START TO EAT SUGAR, 00:34:57.566 --> 00:34:59.866 I NOTICE ALMOST IN LIKE A COUPLE DAYS, 00:34:59.966 --> 00:35:03.500 I WILL FEEL BAD BECAUSE MY BODY'S LIKE FREAKING OUT. 00:35:03.600 --> 00:35:04.600 IT'S MAKING ALL THIS INFLAMMATION. 00:35:04.700 --> 00:35:05.433 DR. BRYAN: WELL, WE CAN EXPLAIN THAT MECHANISTIC 00:35:05.533 --> 00:35:07.200 BECAUSE HERE'S WHAT SUGAR DOES. 00:35:07.300 --> 00:35:08.400 IF YOU EAT SUGAR OR EAT FOODS THAT 00:35:08.500 --> 00:35:10.267 ARE CONVERTED TO SUGAR IN THE BODY, 00:35:10.367 --> 00:35:12.500 IT LEADS TO AN INCREASE IN BLOOD SUGAR 00:35:12.600 --> 00:35:14.233 OR FASTING GLUCOSE. 00:35:14.333 --> 00:35:15.033 SO GLUCOSE, 00:35:15.133 --> 00:35:16.700 AS THE NAME IMPLIES, IS GLUE. 00:35:16.800 --> 00:35:17.966 IT'S STICKY, RIGHT? 00:35:18.066 --> 00:35:18.966 IF YOU SPILL A SODA WATER ON THE 00:35:19.066 --> 00:35:20.733 TABLE TOP AND COME BACK THE NEXT DAY, 00:35:20.833 --> 00:35:21.533 IT'S STICKY. 00:35:21.633 --> 00:35:22.499 REBECCA: YEAH. 00:35:22.599 --> 00:35:23.133 DR. BRYAN: WELL, IT CREATES STICKINESS 00:35:23.233 --> 00:35:24.233 INSIDE THE BODY, 00:35:24.333 --> 00:35:25.566 INSIDE THE LINING OF THE BLOOD VESSELS WHERE BLOOD 00:35:25.666 --> 00:35:27.566 CELLS STARTS STICKING TOGETHER. 00:35:27.666 --> 00:35:30.866 YOU LOSE THE ABILITY TO DELIVER OXYGEN BECAUSE IT 00:35:30.966 --> 00:35:32.700 STICKS TO HEMOGLOBIN AND LOCKS IT IN A 00:35:32.800 --> 00:35:35.433 CONFORMATIONAL STATE WHERE IT CAN'T DELIVER OXYGEN. 00:35:35.533 --> 00:35:38.100 AND THEN IT STICKS TO THE ENZYME THAT MAKES NITRIC OXIDE. 00:35:38.200 --> 00:35:39.966 YOU BECOME NITRIC OXIDE DEFICIENT. 00:35:40.066 --> 00:35:41.233 AND THEN IF YOU EAT A LOT OF SUGAR, 00:35:41.333 --> 00:35:43.233 IT CHANGES THE PH IN YOUR MOUTH. 00:35:43.333 --> 00:35:45.333 IT DROPS THE PH. 00:35:45.433 --> 00:35:46.533 YOUR SALIVARY PH, 00:35:46.633 --> 00:35:48.700 YOUR SALIVA BECOMES VERY ACIDIC. 00:35:48.800 --> 00:35:50.199 AND NOW THAT CREATES AN ENVIRONMENT FOR A 00:35:50.299 --> 00:35:53.333 COMPLETELY DIFFERENT TYPE OF BACTERIA TO POPULATE. 00:35:53.433 --> 00:35:55.599 AND IT'S THE CARIES-CAUSING BACTERIA. 00:35:55.699 --> 00:35:57.466 IT'S THE GINGIVAL PLAQUE, THE BACTERIA THAT CAUSES 00:35:57.566 --> 00:35:59.733 GUM DISEASE, GINGIVITIS. 00:35:59.833 --> 00:36:01.266 SO YOU HAVE TO GET RID OF SUGAR, 00:36:01.366 --> 00:36:03.633 THEN THE OTHER BIG THING IS MOUTH BREATHERS. 00:36:03.733 --> 00:36:04.666 YOU KNOW, THE MOUTH IS NOT FOR BREATHING, 00:36:04.766 --> 00:36:06.533 IT'S FOR SPEAKING. 00:36:06.633 --> 00:36:07.500 SO PEOPLE WHO SLEEP WITH 00:36:07.600 --> 00:36:09.033 THEIR MOUTH OPEN AGAIN, 00:36:09.133 --> 00:36:11.966 YOU'RE FULLY OXYGENATING THAT ORAL CAVITY. 00:36:12.066 --> 00:36:12.733 REBECCA: ALL NIGHT LONG. 00:36:12.833 --> 00:36:14.133 DR. BRYAN: ALL NIGHT LONG. 00:36:14.233 --> 00:36:16.067 YOU'RE CHANGING THE PH OF YOUR SALIVA. 00:36:16.167 --> 00:36:18.466 YOU'VE GOT COMPLETE DYSBIOSIS AND YOUR BREATH 00:36:18.566 --> 00:36:20.233 SMELLS LIKE A GUT WAGON WHEN YOU WAKE UP IN THE 00:36:20.333 --> 00:36:22.333 MORNING BECAUSE OF DYSBIOSIS. 00:36:22.433 --> 00:36:23.999 REBECCA: AND YOU KNOW WHAT'S AWFUL ABOUT THAT AND I'LL JUST 00:36:24.099 --> 00:36:26.366 SAY THIS REALLY QUICK AND WE'LL GET BACK ON NITRIC OXIDE, 00:36:26.466 --> 00:36:28.833 BUT IT KIND OF GOES BACK TO HOW IT ALL WORKS TOGETHER. 00:36:28.933 --> 00:36:31.233 PEOPLE USUALLY DID NOT HAVE AN ISSUE WITH MOUTH 00:36:31.333 --> 00:36:34.299 BREATHING, BUT BECAUSE WESTON PRICE. 00:36:34.399 --> 00:36:35.433 HE STUDIED THIS, THE DENTIST. 00:36:35.533 --> 00:36:36.233 DR. BRYAN: YEAH. 00:36:36.333 --> 00:36:37.466 REBECCA: THAT IF HE WENT TO -- 00:36:37.566 --> 00:36:38.833 WHEN THE INDUSTRIAL REVOLUTION, 00:36:38.933 --> 00:36:40.733 BECAUSE HE'S NO LONGER ALIVE, 00:36:40.833 --> 00:36:41.733 PEOPLE WERE HAVING 00:36:41.833 --> 00:36:42.799 A LOT OF TEETH ISSUES. 00:36:42.899 --> 00:36:44.700 HE WENT TO INDIGENOUS COMMUNITIES THAT ATE A 00:36:44.800 --> 00:36:50.133 WHOLE FOODS DIET OF FOODS RICH IN MEAT AND WHOLE FOODS. 00:36:50.233 --> 00:36:51.433 THEY WEREN'T EATING PROCESSED 00:36:51.533 --> 00:36:53.866 AND THEY HAD NO ISSUES. 00:36:53.966 --> 00:36:54.900 AND WHEN YOU WOULD LOOK AT THEM, 00:36:55.000 --> 00:36:57.633 IT'S BECAUSE THEY'RE JAW IS FULLY DEVELOPED. 00:36:57.733 --> 00:36:58.699 THERE'S SPACE FOR THEIR TEETH. 00:36:58.799 --> 00:37:00.766 WELL, WHAT IS A HUGE INDUSTRY, 00:37:00.866 --> 00:37:02.567 EVERYONE NEEDS, ME INCLUDING, NEEDED BRACES. 00:37:02.667 --> 00:37:03.633 DR. BRYAN: YEAH. 00:37:03.733 --> 00:37:04.833 REBECCA: BECAUSE THERE WASN'T ROOM IN MY MOUTH. 00:37:04.933 --> 00:37:07.000 SO A LOT OF PEOPLE ARE MOUTH BREATHING AND ALSO 00:37:07.100 --> 00:37:09.633 TONGUE-TIED, LIP TIES, BUT I WON'T GET INTO THAT. 00:37:09.733 --> 00:37:10.966 I'M JUST PASSIONATE ABOUT THIS. 00:37:11.066 --> 00:37:13.867 UM, A LOT OF PEOPLE ARE MOUTH BREATHING BECAUSE 00:37:13.967 --> 00:37:16.100 THERE IS NOT ENOUGH SPACE. 00:37:16.200 --> 00:37:17.967 AND SO THAT'S A WHOLE OTHER TOPIC. 00:37:18.067 --> 00:37:20.033 BUT PEOPLE CAN MOUTH TAPE AT NIGHT 00:37:20.133 --> 00:37:22.199 AND YOU CAN WORK WITH AN AIRWAY SPECIALIST. 00:37:22.299 --> 00:37:23.100 DR. BRYAN: I ALWAYS RECOMMEND 00:37:23.200 --> 00:37:23.733 AN AIRWAY SPECIALIST BEFORE YOU GO TO 00:37:23.833 --> 00:37:24.633 TAPE IN YOUR MOUTH. 00:37:24.733 --> 00:37:25.266 BECAUSE IF YOU'VE GOT 00:37:25.366 --> 00:37:26.267 AN OBSTRUCTIVE AIRWAY... 00:37:26.367 --> 00:37:27.299 REBECCA: OH, YEAH, YOU'LL CHOKE YOURSELF. 00:37:27.399 --> 00:37:27.866 DR. BRYAN: LAST THING YOU WANT TO DO IS TAPE 00:37:27.966 --> 00:37:28.566 YOUR MOUTH, RIGHT? 00:37:28.666 --> 00:37:29.666 YOUR ONLY SOURCE OF OXYGEN. 00:37:29.766 --> 00:37:30.966 REBECCA: I FORGOT ABOUT THAT. 00:37:31.066 --> 00:37:31.933 DR. BRYAN: DON'T EXPERIMENT WITH THAT. 00:37:32.033 --> 00:37:33.400 REBECCA: NO, YOU'RE RIGHT. 00:37:33.500 --> 00:37:35.199 SO YOU NEED TO GO TO AN AIRWAY SPECIALIST 00:37:35.299 --> 00:37:37.266 AND THERE IS STUFF THAT YOU CAN DO AS AN ADULT. 00:37:37.366 --> 00:37:38.699 UM, OKAY. 00:37:38.799 --> 00:37:39.466 SO THAT'S VERY, THAT'S LIKE 00:37:39.566 --> 00:37:40.533 A LIFE-CHANGING THING, Y'ALL. 00:37:40.633 --> 00:37:41.466 AND IF YOU HAVE LITTLE KIDS, 00:37:41.566 --> 00:37:42.600 YOU CAN REALLY CHANGE. 00:37:42.700 --> 00:37:43.866 DR. BRYAN: NO, I THINK AS A KID, 00:37:43.966 --> 00:37:46.267 IF YOUR KID IS SLEEPING WITH THEIR MOUTH OPEN, 00:37:46.367 --> 00:37:48.733 YOU MUST GO SEE A PEDIATRIC AIRWAY 00:37:48.833 --> 00:37:51.167 SPECIALIST BECAUSE THEY HAVE A PROBLEM. 00:37:51.267 --> 00:37:53.366 AND IT DEVELOPS BEHAVIORAL ISSUES, 00:37:53.466 --> 00:37:55.700 IT DEVELOPS A LOT OF PSYCHOLOGICAL ISSUES. 00:37:55.800 --> 00:37:58.233 YOU HAVE TO GET THEM FULLY OXYGENATED. 00:37:58.333 --> 00:37:59.599 REBECCA: YES, BECAUSE THEY'RE NOT BREATHING. 00:37:59.699 --> 00:38:00.466 DR. BRYAN: THEY'RE NOT BREATHING. 00:38:00.566 --> 00:38:01.599 THEY'RE NOT BEING FULLY OXYGENATED. 00:38:01.699 --> 00:38:02.633 REBECCA: ADHD, AND SO THERE'S A LOT OF KIDS 00:38:02.733 --> 00:38:05.300 THAT ARE BEING MISDIAGNOSED BECAUSE -- 00:38:05.400 --> 00:38:06.133 DR. BRYAN: IT'S AN AIRWAY PROBLEM. 00:38:06.233 --> 00:38:07.233 REBECCA: YEAH. 00:38:07.333 --> 00:38:08.566 DR. BRYAN: AND THEY WANT TO MEDICATE THESE KIDS. 00:38:08.666 --> 00:38:10.233 REBECCA: AND THEY WANT TO TAKE YOUR ADENOIDS AND YOUR TONSILS 00:38:10.333 --> 00:38:12.200 OUT BECAUSE THEY EXPAND BECAUSE YOU'RE BREATHING 00:38:12.300 --> 00:38:13.366 WITH YOUR MOUTH. 00:38:13.466 --> 00:38:15.067 SO THERE'S, YOU KNOW, THIS IS WHAT'S SO FASCINATING. 00:38:15.167 --> 00:38:16.100 DR. BRYAN: AGAIN, IT'S NOT 00:38:16.200 --> 00:38:18.200 ADDRESSING THE ROOT CAUSE OF THE PROBLEM. 00:38:18.300 --> 00:38:21.233 REBECCA: AND IT'S A HUGE PROBLEM IN TODAY'S SOCIETY. 00:38:21.333 --> 00:38:23.600 BUT YEAH, SUGAR AND YOU, YOU KNOW, 00:38:23.700 --> 00:38:24.600 IT'S SO INTERESTING. 00:38:24.700 --> 00:38:26.533 I HAD DR. AMEN ON WHO IS A BRAIN DOCTOR. 00:38:26.633 --> 00:38:27.533 DR. BRYAN: YEAH. 00:38:27.633 --> 00:38:28.699 REBECCA: AND HE LITERALLY SAID OUT OF ALL 00:38:28.799 --> 00:38:29.566 THE HEALTH STUFF, 00:38:29.666 --> 00:38:31.100 HE WAS LIKE I'M PAYING ATTENTION 00:38:31.200 --> 00:38:32.100 TO MY MOUTH HEALTH. 00:38:32.200 --> 00:38:33.266 HE SAID THAT. 00:38:33.366 --> 00:38:34.433 DR. BRYAN: WELL, HE DOES THE PET SCANS OF THE BRAIN 00:38:34.533 --> 00:38:35.533 AND HE CAN SEE 00:38:35.633 --> 00:38:37.999 THE EFFECTS OF SUGAR IN DIFFERENT -- AND ALCOHOL 00:38:38.099 --> 00:38:38.733 AND COCAINE. 00:38:38.833 --> 00:38:39.766 REBECCA: IN YOUR MOUTH. 00:38:39.866 --> 00:38:41.133 DR. BRYAN: AND YEAH, DYSBIOSIS IN YOUR MOUTH. 00:38:41.233 --> 00:38:42.266 REBECCA: YEAH. 00:38:42.366 --> 00:38:43.866 HE SAYS THAT BECAUSE OF THE WAY IT'S CONNECTED. 00:38:43.966 --> 00:38:44.533 HE SAID THERE'S -- 00:38:44.633 --> 00:38:45.699 HE'S LIKE THE EFFECT -- 00:38:45.799 --> 00:38:48.466 HE SAID THAT HE SAW IN HIS PATIENTS THE CONNECTION 00:38:48.566 --> 00:38:49.966 BETWEEN MOUTH HEALTH AND BRAIN HEALTH. 00:38:50.066 --> 00:38:50.833 AND SO HE SAYS -- 00:38:50.933 --> 00:38:52.567 AND HE ALSO WEARS A GLUCOSE MONITOR. 00:38:52.667 --> 00:38:53.699 SO AFTER YOU TALK -- 00:38:53.799 --> 00:38:54.800 I HEARD YOU TALKING ABOUT THAT, 00:38:54.900 --> 00:38:57.133 I WAS LIKE I KIND OF WANT TO GET ONE BECAUSE YOU 00:38:57.233 --> 00:38:58.233 WON'T REALLY -- 00:38:58.333 --> 00:38:59.066 THAT'S WHAT HE SAID, HE'S LIKE YOU WON'T REALLY 00:38:59.166 --> 00:39:00.233 KNOW WHAT SPIKING YOU. 00:39:00.333 --> 00:39:00.733 DR. BRYAN: YOU GOT TO KNOW HOW YOUR BODY RESPONDS. 00:39:00.833 --> 00:39:02.000 REBECCA: EXACTLY. 00:39:02.100 --> 00:39:04.066 IF YOU, BECAUSE A LOT OF DISEASE ALSO IS 00:39:04.166 --> 00:39:06.467 COMING FROM INSULIN RESISTANCE. 00:39:06.567 --> 00:39:07.566 MOST PEOPLE ARE 00:39:07.666 --> 00:39:09.467 INSULIN RESISTANT AND THEY DON'T KNOW IT. 00:39:09.567 --> 00:39:12.066 BECAUSE PEOPLE JUST THINK OH, IF YOU HAVE DIABETES, 00:39:12.166 --> 00:39:13.366 BUT IT CAN COME -- 00:39:13.466 --> 00:39:15.399 EVEN PEOPLE WHO ARE NOT OVERWEIGHT, 00:39:15.499 --> 00:39:16.466 EVEN THOUGH MOST PEOPLE IN AMERICA ARE 00:39:16.566 --> 00:39:18.133 OVERWEIGHT NOW WHICH IS KIND OF CRAZY. 00:39:18.233 --> 00:39:19.267 THAT'S ANOTHER EPIDEMIC. 00:39:19.367 --> 00:39:20.367 DR. BRYAN: YEAH. 00:39:20.467 --> 00:39:22.633 REBECCA: UM, BUT YOU CAN HAVE INSULIN RESISTANCE 00:39:22.733 --> 00:39:24.867 AND NOT EVEN KNOW IT. 00:39:24.967 --> 00:39:25.533 DR. BRYAN: WELL, WHAT WE FOUND, 00:39:25.667 --> 00:39:27.833 WE PUBLISHED THIS IN 2011. 00:39:27.933 --> 00:39:31.766 INSULIN RESISTANCE IS A SYMPTOM OF NITRIC OXIDE DEFICIENCY. 00:39:31.866 --> 00:39:33.466 SO IF THE CELL CAN'T MAKE NITRIC OXIDE, 00:39:33.566 --> 00:39:34.900 INSULIN CAN'T DO ITS JOB 00:39:35.000 --> 00:39:37.133 AND SIGNAL TO BRING GLUCOSE INTO THE 00:39:37.233 --> 00:39:39.200 CELL AND CLEAR IT FROM THE CIRCULATION. 00:39:39.300 --> 00:39:40.566 REBECCA: REALLY? 00:39:40.666 --> 00:39:41.433 DR. BRYAN: SO THE BROKEN SYSTEM 00:39:41.533 --> 00:39:42.567 INSULIN RESISTANCE -- 00:39:42.667 --> 00:39:44.666 YOU BECOME RESISTANT TO INSULIN BECAUSE THE CELL 00:39:44.766 --> 00:39:46.333 CAN'T MAKE NITRIC OXIDE. 00:39:46.433 --> 00:39:47.399 REBECCA: THAT IS HUGE. 00:39:47.499 --> 00:39:48.933 DR. BRYAN: SO WHEN THE CELL MAKES NITRIC OXIDE, 00:39:49.033 --> 00:39:49.566 IT ACTIVATES 00:39:49.666 --> 00:39:51.533 A PROTEIN CALLED GLUT4, 00:39:51.633 --> 00:39:52.466 WHICH TELLS IT TO GO TO 00:39:52.566 --> 00:39:53.733 THE MEMBRANE, BRING GLUCOSE, CLEAR IT 00:39:53.833 --> 00:39:55.033 FROM THE CIRCULATION. 00:39:55.133 --> 00:39:58.933 AND THAT'S HOW WE CLEAR GLUCOSE AFTER A MEAL. 00:39:59.033 --> 00:40:01.500 AND THAT'S WHAT KEEPS YOU FROM GETTING THE GLUCOSE SPIKE. 00:40:01.600 --> 00:40:03.767 AND AS LONG AS INSULIN IS - YOUR BODY, YOUR CELLS ARE 00:40:03.867 --> 00:40:06.299 SENSITIVE TO IT, THEN INSULIN SPIKES, 00:40:06.399 --> 00:40:07.200 BUT IT GOES DOWN. 00:40:07.300 --> 00:40:08.567 GLUCOSE SPIKES, BUT IT COMES DOWN, 00:40:08.667 --> 00:40:10.833 AND THAT'S HOW WE REGULATE BLOOD SUGAR. 00:40:10.933 --> 00:40:12.800 BUT IF YOU CAN'T MAKE NITRIC OXIDE, 00:40:12.900 --> 00:40:14.433 YOU CAN'T GET GLUCOSE INTO THE CELL, 00:40:14.533 --> 00:40:15.100 THEN IT TELLS YOUR PANCREAS, 00:40:15.200 --> 00:40:17.000 HEY, I NEED MORE INSULIN. 00:40:17.100 --> 00:40:18.299 PUT, PUSH MORE INSULIN, PUSH MORE INSULIN. 00:40:18.399 --> 00:40:19.466 THEN YOU GET Hyperinsulinemia, 00:40:19.566 --> 00:40:21.367 HYPERGLYCEMIA AND THAT'S 00:40:21.467 --> 00:40:24.266 THE CASCADE OF INFLAMMATION THAT LEADS TO 00:40:24.366 --> 00:40:28.333 DIABETIC NEUROPATHY, MACULAR DEGENERATION, HEART 00:40:28.433 --> 00:40:30.899 ATTACK, STROKE, POOR HEALING WOUNDS 00:40:30.999 --> 00:40:32.267 THAT EXPLAINS EVERYTHING ABOUT DIABETES. 00:40:32.367 --> 00:40:35.633 REBECCA: BECAUSE DIABETES AFFECTS BLOOD FLOW RIGHT. 00:40:35.733 --> 00:40:37.066 AND THAT'S WHY PEOPLE LIKE THEY CAN 00:40:37.166 --> 00:40:38.399 HAVE PROBLEMS WITH THEIR -- 00:40:38.499 --> 00:40:40.033 DR. BRYAN: WELL, NEUROPATHY, THE SMALL FIBERS, 00:40:40.133 --> 00:40:41.800 WHETHER IT'S, YOU KNOW, 00:40:41.900 --> 00:40:43.533 SMALL FIBER DISEASE OR LARGE FIBER DISEASE, 00:40:43.633 --> 00:40:47.566 THOSE, THOSE NERVES HAVE TO HAVE BLOOD VESSELS SUPPLY, RIGHT? 00:40:47.666 --> 00:40:49.900 AND SO WHEN YOU'RE DIABETIC, YOU HAVE 00:40:50.000 --> 00:40:51.033 MICROVASCULAR DYSFUNCTION. 00:40:51.133 --> 00:40:52.233 YOU CAN'T MAKE NITRIC OXIDE. 00:40:52.333 --> 00:40:54.866 SO THOSE NERVE FIBERS ARE NO LONGER GETTING PERFUSED. 00:40:54.966 --> 00:40:56.000 THERE'S NO SODIUM. 00:40:56.100 --> 00:40:57.333 THERE'S NO POTASSIUM, YOU CAN'T ELICIT ON ACTION 00:40:57.433 --> 00:40:59.066 POTENTIAL IN YOUR DEVELOPING NEUROPATHY. 00:40:59.166 --> 00:41:00.666 REBECCA: SO WHAT'S SO INTERESTING ABOUT THIS 00:41:00.766 --> 00:41:03.000 CONVERSATION IS BASICALLY FINDING OUT THAT NITRIC 00:41:03.100 --> 00:41:06.500 OXIDE HELPS THE BODY, THE CELLS IN 00:41:06.600 --> 00:41:07.966 A LOT OF DIFFERENT WAYS. 00:41:08.066 --> 00:41:09.666 DR. BRYAN: NOW I TELL PEOPLE IT'S FOUNDATIONAL, 00:41:09.766 --> 00:41:10.833 IT'S AN ESSENTIAL MOLECULE. 00:41:10.933 --> 00:41:11.833 IT'S NOT, LOOK, 00:41:11.933 --> 00:41:12.800 IT'S NOT A PANACEA. 00:41:12.900 --> 00:41:14.833 IT'S NOT A END-ALL, BE-ALL CURE-ALL, 00:41:14.933 --> 00:41:16.366 BUT HERE'S WHAT WE DO KNOW 00:41:16.466 --> 00:41:18.833 THAT YOUR BODY CANNOT AND WILL NOT HEAL OR BECOME 00:41:18.933 --> 00:41:21.500 OPTIMIZED WITHOUT ADEQUATE NITRIC OXIDE. 00:41:21.600 --> 00:41:22.933 THERE MAY BE OTHER THINGS THAT ARE CONTRIBUTING 00:41:23.033 --> 00:41:24.233 TO YOUR DISEASE. 00:41:24.333 --> 00:41:25.900 BUT AT THE END OF THE DAY, 00:41:26.000 --> 00:41:26.800 IF YOU'VE GOT CHRONIC DISEASE, 00:41:26.900 --> 00:41:28.366 YOU HAVE NITRIC OXIDE DEFICIENCY. 00:41:28.466 --> 00:41:31.067 LET'S FIRST RESTORE THE PRODUCTION OF NITRIC OXIDE, 00:41:31.167 --> 00:41:32.500 THEN LET'S FOCUS ON 00:41:32.600 --> 00:41:34.299 WHAT NUTRIENTS ARE YOU DEFICIENT IN? 00:41:34.399 --> 00:41:36.033 WHAT TOXINS ARE YOU EXPOSED TO? 00:41:36.133 --> 00:41:39.666 FIX THAT AND THEN YOUR BODY HEALS ITSELF. 00:41:39.766 --> 00:41:40.966 REBECCA: THAT'S SO GOOD. 00:41:41.066 --> 00:41:42.733 UM, WHAT I LOVE ABOUT 00:41:42.833 --> 00:41:45.233 WHAT YOU'VE DEVELOPED TOO IS THAT, 00:41:45.333 --> 00:41:47.233 IT'S -- YOU'VE HAD PATIENTS WHO ARE 00:41:47.333 --> 00:41:49.099 ON VARIOUS PRESCRIPTION DRUGS 00:41:49.199 --> 00:41:52.066 TAKE THIS AND IT'S HAD NO NEGATIVE. 00:41:52.166 --> 00:41:52.967 BECAUSE A LOT OF TIMES, 00:41:53.067 --> 00:41:55.366 THERE'S THAT RISK OF IF TAKE THIS, 00:41:55.466 --> 00:41:56.800 IT'S GOING TO INTERFERE WITH MY OTHER... 00:41:56.900 --> 00:41:57.700 DR. BRYAN: YEAH. 00:41:57.800 --> 00:41:58.300 REBECCA: PRESCRIPTIONS SO IT SHOWS 00:41:58.400 --> 00:42:00.033 REALLY HOW SAFE IT IS. 00:42:00.133 --> 00:42:01.600 CAN YOU SPEAK TO THAT? 00:42:01.700 --> 00:42:02.533 DR. BRYAN: YEAH. 00:42:02.633 --> 00:42:03.767 LOOK, WE HAVE A LONG HISTORY OF SAFETY 00:42:03.867 --> 00:42:04.900 BECAUSE NUMBER ONE, 00:42:05.000 --> 00:42:07.600 I KNOW HOW MUCH NITRIC OXIDE THE HUMAN BODY MAKES 00:42:07.700 --> 00:42:08.533 AND I WANT TO GIVE THAT BACK. 00:42:08.633 --> 00:42:09.633 SO I'M NEVER GIVING 00:42:09.733 --> 00:42:12.166 MORE THAN WHAT THE BODY IS USUALLY EXPOSED TO. 00:42:12.266 --> 00:42:13.267 BUT THEN WHAT WE DIDN'T KNOW, 00:42:13.367 --> 00:42:14.433 WHAT WE DID KNOW 00:42:14.533 --> 00:42:17.567 PRIOR TO FOUR YEARS AGO WAS WHAT ABOUT PEOPLE THAT 00:42:17.667 --> 00:42:20.666 ARE ON DIFFERENT MEDICATIONS, POLYPHARMACY. 00:42:20.766 --> 00:42:21.866 AND DURING OUR COVID DRUG STUDY, 00:42:21.966 --> 00:42:24.500 WE HAD OUR NITRIC OXIDE RELEASING LOZENGE AND IN A 00:42:24.600 --> 00:42:27.433 PHASE THREE CLINICAL TRIAL FOR COVID AND FOUND THAT 00:42:27.533 --> 00:42:28.533 IN SOME OF THESE PATIENTS WERE 00:42:28.633 --> 00:42:30.500 ON 20 DIFFERENT MEDICATIONS. 00:42:30.600 --> 00:42:32.399 WHEN WE DID A CENSUS OF WHAT 00:42:32.499 --> 00:42:34.399 MEDICATIONS THEY WERE TAKING, 00:42:34.499 --> 00:42:36.799 I MEAN, PEOPLE ARE OVERMEDICATED. 00:42:36.899 --> 00:42:39.500 SO THE POINT IS THAT EVEN WHEN WE GAVE OUR LOZENGE 00:42:39.600 --> 00:42:42.133 ON TOP OF THEIR 20 DIFFERENT MEDICATIONS, 00:42:42.233 --> 00:42:44.967 THERE WAS NO INTERACTIONS WITH ANY OF THE MEDICATIONS. 00:42:45.067 --> 00:42:46.667 THERE WAS NO UNSAFE DROP IN BLOOD PRESSURE. 00:42:46.767 --> 00:42:49.900 IN FACT, THERE WAS NO SAFETY SIGNAL WHATSOEVER. 00:42:50.000 --> 00:42:52.333 SO WE KNOW THAT OUR DRUG TECHNOLOGY AND OUR PRODUCT 00:42:52.433 --> 00:42:55.099 DELIVERY IS EXTREMELY SAFE THAT DOESN'T INTERACT WITH 00:42:55.199 --> 00:42:57.700 MEDICATIONS AND LEAD TO AN UNSAFE DROP IN BLOOD PRESSURE. 00:42:57.800 --> 00:42:59.466 SO THAT'S NUMBER ONE, FIRST DO NO HARM. 00:42:59.566 --> 00:43:02.400 I MEAN, SAFETY IS THE UTMOST NUMBER ONE PRIORITY. 00:43:02.500 --> 00:43:05.367 AND THEN NUMBER TWO, IS IT EFFECTIVE? 00:43:05.467 --> 00:43:07.067 WELL, WE KNOW AND WE'VE HAD CONVERSATIONS 00:43:07.167 --> 00:43:08.200 AND MANY PHYSICIANS 00:43:08.300 --> 00:43:11.200 USE THIS IN THEIR PATIENTS AND START HAVING FOR THE 00:43:11.300 --> 00:43:12.466 FIRST TIME A CONVERSATION 00:43:12.566 --> 00:43:15.633 of, OKAY, WE'VE HAD YOU ON THESE BLOOD PRESSURE MEDICINES 00:43:15.733 --> 00:43:16.799 FOR 20 YEARS. 00:43:16.899 --> 00:43:17.866 NOW IT SEEMS LIKE YOUR BLOOD 00:43:17.966 --> 00:43:18.800 PRESSURE IS BETTER MANAGED. 00:43:18.900 --> 00:43:21.033 LET'S BACK OFF THOSE AND LET'S SEE 00:43:21.133 --> 00:43:21.967 IF WE CAN START WEANING 00:43:22.067 --> 00:43:24.300 YOU OFF OF PRESCRIPTION MEDICATION. 00:43:24.400 --> 00:43:25.400 AND LO AND BEHOLD, AGAIN, 00:43:25.500 --> 00:43:26.733 WE FOCUS ON THE TARGET. 00:43:26.833 --> 00:43:28.433 WE FOCUS ON THE MICROBIOME. 00:43:28.533 --> 00:43:30.000 WE ELIMINATE TOXINS. 00:43:30.100 --> 00:43:31.733 WE REPLETE NUTRIENTS 00:43:31.833 --> 00:43:33.666 and THERE'S NO NEED FOR PRESCRIPTION MEDICATION. 00:43:33.766 --> 00:43:35.300 rebecca: THAT'S AMAZING. 00:43:35.400 --> 00:43:37.966 THAT IS SO AMAZING. 00:43:38.066 --> 00:43:39.599 HAVE YOU NOTICED, 00:43:39.699 --> 00:43:41.800 WELL, I DON'T EVEN KNOW BECAUSE I KNOW 00:43:41.900 --> 00:43:42.800 WITH PREGNANT PEOPLE, 00:43:42.900 --> 00:43:43.766 THEY DON'T EVER -- WOMEN, 00:43:43.866 --> 00:43:44.967 THEY DON'T EVER WANT TO DO ANYTHING,. 00:43:45.067 --> 00:43:46.467 BUT I KNOW THAT PREECLAMPSIA IS A MASSIVE 00:43:46.567 --> 00:43:48.900 ISSUE IN PREGNANCY AND THAT'S A BLOOD -- 00:43:49.000 --> 00:43:49.433 DR. BRYAN: THAT'S A BLOOD 00:43:49.533 --> 00:43:50.399 PRESSURE PROBLEM. 00:43:50.499 --> 00:43:52.333 YES, SO MY WIFE TOOK OUR PRODUCT DURING 00:43:52.433 --> 00:43:53.900 ALL THE PREGNANCIES. 00:43:54.000 --> 00:43:55.333 UH, EARLY FORMS OF IT. 00:43:55.433 --> 00:43:58.766 AND THEN EARLY ON, WE DID A STUDY AT MEMORIAL HERMANN 00:43:58.866 --> 00:44:02.233 OR -- BEEN TAUGHT IN HIGH-RISK PREGNANCIES 00:44:02.333 --> 00:44:04.733 AND SPECIFICALLY PREECLAMPSIA. 00:44:04.833 --> 00:44:05.833 AND THE PROBLEM WITH PREECLAMPSIA 00:44:05.933 --> 00:44:07.599 IS YOU DEVELOP REALLY HIGH BLOOD PRESSURE. 00:44:07.699 --> 00:44:08.766 rebecca: yeah, AND THEN IT causes 00:44:08.866 --> 00:44:10.033 A BUNCH OF PROBLEMS. 00:44:10.133 --> 00:44:13.633 DR. BRYAN: well, THE ONLY TREATMENT IS PREMATURE DELIVERY. 00:44:13.733 --> 00:44:15.000 REBECCA: YEAH, WHICH IS AWFUL. 00:44:15.100 --> 00:44:16.900 DR. BRYAN: BECAUSE IF YOU TREAT WITH BLOOD PRESSURE MEDICINES, 00:44:17.000 --> 00:44:19.933 A LOT OF TIMES IT'LL CAUSE INCREASE IN 00:44:20.033 --> 00:44:21.166 INTRACRANIAL PRESSURES AND THE WOMEN WILL 00:44:21.266 --> 00:44:22.733 GO INTO SEIZURES. 00:44:22.833 --> 00:44:24.367 SO YOU HAVE TO BE VERY CAREFUL ON HOW YOU TREAT THEM. 00:44:24.467 --> 00:44:25.033 REBECCA: YEAH. 00:44:25.133 --> 00:44:26.099 DR. BRYAN: SO WE TOOK, 00:44:26.199 --> 00:44:28.467 I THINK IT WAS 4 TO 5 PREECLAMPTIC PATIENTS 00:44:28.567 --> 00:44:29.799 THAT WERE ADMITTED. 00:44:29.899 --> 00:44:31.633 WE DOSED THEM WITH OUR LOZENGE. 00:44:31.733 --> 00:44:33.433 IT NORMALIZED THEIR BLOOD PRESSURE. 00:44:33.533 --> 00:44:34.299 IT DIDN'T CAUSE AN 00:44:34.399 --> 00:44:36.100 INCREASE IN INTRACRANIAL PRESSURES. 00:44:36.200 --> 00:44:38.600 WE DID AN ULTRASOUND OF THE FETUS, 00:44:38.700 --> 00:44:40.433 AND IT WAS VERY WELL-TOLERATED. 00:44:40.533 --> 00:44:41.400 AND IN SOME OF THOSE PATIENTS, 00:44:41.533 --> 00:44:44.700 WE COULD EXTEND GESTATION FOR 7 OR 10 DAYS. 00:44:44.800 --> 00:44:45.500 AND THINK ABOUT THAT. 00:44:45.600 --> 00:44:46.666 REBECCA: THAT'S HUGE. 00:44:46.766 --> 00:44:49.333 DR. BRYAN: I MEAN, FROM A, FROM A DEVELOPING BABY 00:44:49.433 --> 00:44:50.433 AND A PREMATURE BABY 00:44:50.533 --> 00:44:52.233 THAT'S UNDERDEVELOPED, THE RISK... 00:44:52.333 --> 00:44:53.300 REBECCA: YES. 00:44:53.400 --> 00:44:55.133 DR. BRYAN: YOU KNOW, OF EVEN INFANT MORTALITY. 00:44:55.233 --> 00:44:56.333 YOU KNOW, EVEN MOTHER MORTALITY 00:44:56.433 --> 00:44:57.366 IS STILL EXTREMELY HIGH. 00:44:57.466 --> 00:44:58.233 SO IF WE CAN EXTEND GESTATION, 00:44:58.299 --> 00:45:00.133 MANAGE THEIR BLOOD PRESSURE, 00:45:00.233 --> 00:45:02.000 THEN BOTH MOTHER AND BABY ARE GOING TO BE 00:45:02.100 --> 00:45:02.900 BETTER FOR IT. 00:45:03.000 --> 00:45:04.033 AND IT WAS AN AMAZING FINDING. 00:45:04.133 --> 00:45:05.133 WE NEVER FOLLOWED 00:45:05.233 --> 00:45:07.166 UP ON IT BECAUSE THAT'S A, AGAIN, A DRUG STUDY 00:45:07.266 --> 00:45:09.033 THAT'S VERY EXPENSIVE AND LONG-TERM, BUT -- 00:45:09.133 --> 00:45:10.333 REBECCA: YEAH. 00:45:10.433 --> 00:45:12.233 DR. BRYAN: I MEAN, PRACTICALLY IT WORKS, 00:45:12.333 --> 00:45:13.900 AND WE'RE, WE'RE I STILL 00:45:14.000 --> 00:45:15.200 TELL PEOPLE IF YOU HAVE PREECLAMPSIA 00:45:15.300 --> 00:45:17.133 OR GESTATIONAL DIABETES, 00:45:17.233 --> 00:45:18.533 THE LOZENGE IS COMPLETELY SAFE. 00:45:18.633 --> 00:45:19.700 REBECCA: OH, YEAH, I FORGOT ABOUT 00:45:19.800 --> 00:45:21.300 GESTATIONAL DIABETES. 00:45:21.400 --> 00:45:22.366 YEAH, PREECLAMPSIA, 00:45:22.466 --> 00:45:23.433 I MEAN, JUST BECAUSE, YOU KNOW, 00:45:23.533 --> 00:45:24.799 I'VE HAD MY OWN BABIES. 00:45:24.899 --> 00:45:25.666 I'M ALWAYS TALKING TO WOMEN. 00:45:25.766 --> 00:45:26.800 A LOT OF WOMEN HAVE THAT 00:45:26.900 --> 00:45:28.299 AND IT CAUSES A LOT OF COMPLICATIONS. 00:45:28.399 --> 00:45:30.633 AND I'VE EVEN KNOWN PEOPLE THAT HAD COMPLICATIONS WITH IT 00:45:30.733 --> 00:45:31.533 AFTER GIVING BIRTH. 00:45:31.633 --> 00:45:33.566 I MEAN, WHERE THEIR BLOOD PRESSURE 00:45:33.666 --> 00:45:36.299 AND, YOU KNOW, THEY HAD TO BE ADMITTED TO A HOSPITAL 00:45:36.399 --> 00:45:37.733 RIGHT AFTER GIVING BIRTH. 00:45:37.833 --> 00:45:39.967 UM, AND SO IF SOMETHING COULD HELP MITIGATE THAT, 00:45:40.067 --> 00:45:40.800 THAT WOULD BE, 00:45:40.900 --> 00:45:42.866 THAT'S, THIS IS AMAZING. 00:45:42.966 --> 00:45:43.333 I LOVE THAT. 00:45:43.433 --> 00:45:44.400 DR. BRYAN: YEAH, 00:45:44.500 --> 00:45:45.533 WE'VE DONE A LOT OF WORK WITH PREGNANCY AND 00:45:45.633 --> 00:45:48.399 EVEN NURSING, YOU KNOW, ANALYZING BREAST MILK AND 00:45:48.499 --> 00:45:49.666 BABIES ARE GETTING A REALLY RICH 00:45:49.766 --> 00:45:52.100 SOURCE OF NITRIC OXIDE THROUGH BREAST MILK 00:45:52.200 --> 00:45:53.700 THAT'S NOT PRESENT IN FORMULA. 00:45:53.800 --> 00:45:54.833 REBECCA: THAT'S SO COOL. 00:45:54.933 --> 00:45:58.066 DR. BRYAN: SO WE 2020, 2011 PAPER WE PUBLISHED, 00:45:58.166 --> 00:46:01.300 WE ARGUED THAT THE HEALTH BENEFITS CONFERRED THROUGH 00:46:01.400 --> 00:46:04.666 BREASTFEEDING IS PARTLY DEPENDENT UPON NITRIC OXIDE. 00:46:04.766 --> 00:46:07.233 IT'S NOT JUST THE PASSAGE OF THE IMMUNOGLOBULINS. 00:46:07.333 --> 00:46:09.199 BUT, YOU KNOW, BABIES WHO ARE BREASTFED FOR AT LEAST 00:46:09.299 --> 00:46:11.566 SIX MONTHS HAVE LOWER INCIDENTS OF DIABETES, 00:46:11.666 --> 00:46:13.967 HIGH BLOOD PRESSURE, AUTOIMMUNE DISEASE 00:46:14.067 --> 00:46:15.200 LATER IN LIFE. 00:46:15.300 --> 00:46:17.766 AND WE ARGUE THAT IT'S PARTIALLY A NITRIC OXIDE PROBLEM. 00:46:17.866 --> 00:46:20.133 AND EVEN WHEN MY LAST SON WAS BORN, 00:46:20.233 --> 00:46:23.966 I COLLECTED THE, UH, THE EMBRYONIC FLUID DURING DELIVERY. 00:46:24.066 --> 00:46:24.700 WE WERE IN THERE, 00:46:24.800 --> 00:46:25.367 AND WHEN THE WATER BROKE, 00:46:25.467 --> 00:46:26.233 I GOTTA HAVE SOME OF THAT, 00:46:26.333 --> 00:46:26.900 AND WE TOOK IT TO THE LAB 00:46:27.000 --> 00:46:27.633 AND WE ANALYZED IT. 00:46:27.733 --> 00:46:29.266 BUT THESE BABIES DURING NINE 00:46:29.366 --> 00:46:32.533 MONTHS OF GESTATION ARE BATHED IN A REALLY NITRIC 00:46:32.633 --> 00:46:34.533 OXIDE RICH ENVIRONMENT. 00:46:34.633 --> 00:46:35.200 REBECCA: REALLY! 00:46:35.300 --> 00:46:36.000 THAT IS SO INTERESTING. 00:46:36.100 --> 00:46:36.833 DR. BRYAN: AND THEN WHEN YOU 00:46:36.933 --> 00:46:37.500 HAVE VAGINALLY-DELIVERED BABIES, 00:46:37.600 --> 00:46:38.766 YOU'RE GETTING INOCULATED 00:46:38.866 --> 00:46:39.900 RIGHT THROUGH THE VAGINAL CANAL. 00:46:40.000 --> 00:46:41.600 WHERE CESAREAN DELIVERY, 00:46:41.700 --> 00:46:43.466 THEY LACK THAT INOCULATION. 00:46:43.566 --> 00:46:44.533 AND WE KNOW THAT VAGINAL 00:46:44.633 --> 00:46:46.900 DELIVERED BABIES HAVE BETTER IMMUNE SYSTEMS 00:46:47.000 --> 00:46:47.966 THAN CESAREAN. 00:46:48.066 --> 00:46:49.866 SO WE ARGUED AGAIN THAT THERE'S A, THERE'S A 00:46:49.966 --> 00:46:53.900 CRITICAL ROLE FOR INOCULATION OF THOSE GOOD BACTERIA, 00:46:54.000 --> 00:46:55.099 THAT IF WE CAN RESTORE THAT AND 00:46:55.199 --> 00:46:57.766 RECAPITULATE THAT EVEN THROUGH CESAREAN DELIVERIES, 00:46:57.866 --> 00:46:58.767 THEN THE BABY WILL BE HEALTHIER 00:46:58.867 --> 00:47:00.433 FOR IT AND BREASTFEEDING. 00:47:00.533 --> 00:47:03.666 REBECCA: THEY'RE JUST STARTING TO, I JUST SAW WHERE THEY, 00:47:03.766 --> 00:47:04.333 THEY'RE DOING STUDIES 00:47:04.433 --> 00:47:06.533 NOW ON CESAREAN BABIES. 00:47:06.633 --> 00:47:07.433 AND, I MEAN, IN AMERICA, 00:47:07.533 --> 00:47:08.700 WE HAVE A HIGH, 00:47:08.800 --> 00:47:11.466 I MEAN, WAY TOO HIGH OF A NUMBER OF WOMEN GETTING C-SECTIONS. 00:47:11.566 --> 00:47:13.833 AND WHAT BREAKS MY HEART IS I KNOW WOMEN 00:47:13.933 --> 00:47:17.300 AND I'VE SEEN WOMEN STORIES WHERE THEY DON'T 00:47:17.400 --> 00:47:19.666 KNOW THE RISKS INVOLVED. 00:47:19.766 --> 00:47:20.800 I MEAN, IT'S ONE THING TO GO INTO BIRTH 00:47:20.900 --> 00:47:22.000 AND NEED A C-SECTION. 00:47:22.100 --> 00:47:24.399 IT'S ANOTHER THING TO JUST CHOOSE TO GET A C-SECTION. 00:47:24.499 --> 00:47:26.600 AND DOCTORS AREN'T TELLING THEM ALL THE THINGS THEIR 00:47:26.700 --> 00:47:28.233 BABIES ARE MISSING OUT ON. 00:47:28.333 --> 00:47:30.133 AND NOW THEY'RE DOING RESEARCH. 00:47:30.233 --> 00:47:33.533 AND, I MEAN, THAT PASSAGE OF THE BABY THROUGH THEY, YOU KNOW. 00:47:33.633 --> 00:47:34.433 I THINK ONE, 00:47:34.533 --> 00:47:35.566 THEY CALL IT LIKE THE CANAL OF LIFE. 00:47:35.666 --> 00:47:38.499 AND IT'S BECAUSE THAT BACTERIA IS SETTING UP THEIR 00:47:38.599 --> 00:47:40.433 MICROBIOME FOR THE REST OF THEIR LIFE. 00:47:40.533 --> 00:47:42.267 AND THEN THAT BREASTFEEDING ALSO 00:47:42.367 --> 00:47:44.266 CONTRIBUTES TO THAT MICROBIOME FOR 00:47:44.366 --> 00:47:45.233 THE REST OF THEIR LIFE. 00:47:45.333 --> 00:47:47.133 AND THEY DID A STUDY ON BABIES AND A LOT 00:47:47.233 --> 00:47:49.233 OF THEM WERE DEFICIENT IN, 00:47:49.333 --> 00:47:50.233 I CAN'T SAY THE BACTERIA NAME. 00:47:50.333 --> 00:47:51.800 IT'S LIKE B INFANTIS. 00:47:51.900 --> 00:47:52.700 DR. BRYAN: Bifidobacterium. 00:47:52.800 --> 00:47:53.533 REBECCA: YES. 00:47:53.633 --> 00:47:55.833 IT'S A VERY ESSENTIAL BACTERIA. 00:47:55.933 --> 00:47:56.899 AND THEN ON TOP 00:47:56.999 --> 00:47:58.666 OF THAT, I MEAN, OVERPRESCRIPTION OF ANTIBIOTICS. 00:47:58.766 --> 00:48:02.699 SO TO BE MINDFUL OF THE MICROBIOME AND SEE HOW 00:48:02.799 --> 00:48:05.033 THIS CAN HELP PLAY A ROLE IN HELPING SUPPORT 00:48:05.133 --> 00:48:06.800 THAT IS MASSIVE. 00:48:06.900 --> 00:48:08.366 DR. BRYAN: YEAH, WE THINK IT'S A GAME CHANGER. 00:48:08.466 --> 00:48:10.299 I MEAN, WE LIVE IN THIS, 00:48:10.399 --> 00:48:13.333 YOU KNOW, GERMOPHOBIC SOCIETY WHERE, YOU KNOW, 00:48:13.433 --> 00:48:14.799 I STILL GET ON A PLANE EVERY WEEK AND THEY'RE 00:48:14.899 --> 00:48:17.866 GIVING ME THE ANTIBACTERIAL, ANTISEPTIC 00:48:17.966 --> 00:48:20.100 CLOTHS AND TRYING TO -- AND I STILL SIT NEXT TO PEOPLE 00:48:20.200 --> 00:48:21.966 WHO ARE WIPING EVERYTHING DOWN. 00:48:22.066 --> 00:48:23.066 AND USE, BATHE TWO OR 00:48:23.166 --> 00:48:24.833 THREE TIMES A DAY WITH ANTIBACTERIAL SOAPS, 00:48:24.933 --> 00:48:28.000 ANTIBACTERIAL MOUTHWASH AND FLUORIDE TOOTHPASTE. 00:48:28.100 --> 00:48:30.600 AND THEY'RE SICK, THEY'RE UNHEALTHY. 00:48:30.700 --> 00:48:31.533 REBECCA: YEAH. 00:48:31.633 --> 00:48:32.733 DR. BRYAN: AND WE HAVE TO, YOU KNOW, 00:48:32.833 --> 00:48:35.366 I LIKE TO USE NATURE AS AN EXAMPLE. 00:48:35.466 --> 00:48:36.900 AND I HAVE A RANCH 00:48:37.000 --> 00:48:39.466 JUST THREE HOURS SOUTH OF HERE AND HAVE HORSES 00:48:39.566 --> 00:48:40.900 AND DOGS AND SO... 00:48:41.000 --> 00:48:42.466 I NOTICED IF YOU BATHE YOUR HORSE 00:48:42.566 --> 00:48:43.200 OR BATHE YOUR DOG, 00:48:43.300 --> 00:48:44.000 WHAT DO THEY DO? 00:48:44.100 --> 00:48:45.000 THEY GO ROLL IN THE DIRT. 00:48:45.100 --> 00:48:45.833 REBECCA: YEAH 00:48:45.933 --> 00:48:46.566 DR. BRYAN: RIGHT? 00:48:46.666 --> 00:48:47.866 SO THEY'RE REINOCULATED. 00:48:47.966 --> 00:48:49.566 THEY'RE A LOT SMARTER THAN WE ARE BECAUSE THEY DON'T WANT, 00:48:49.666 --> 00:48:51.666 THEY KNOW THEY HAVE TO REINOCULATE. 00:48:51.766 --> 00:48:53.233 AND THOSE AMMONIA-OXIDIZING BACTERIA 00:48:53.333 --> 00:48:54.833 THAT ARE FOUND IN THE SOIL, 00:48:54.933 --> 00:48:56.667 WHEN WE SWEAT, WE SECRETE AMMONIA. 00:48:56.767 --> 00:48:58.066 THERE'S AMMONIA-OXIDIZING BACTERIA 00:48:58.166 --> 00:49:00.267 THAT PRODUCES NITRIC OXIDE. 00:49:00.367 --> 00:49:02.033 AND SO IT'S A, IT'S AN ECOLOGY OF 00:49:02.133 --> 00:49:05.599 NITRIC-OXIDE PRODUCING SYSTEMS BASED ON THE BACTERIA THAT 00:49:05.699 --> 00:49:08.300 LIVE IN OUR BODY AND ON OUR BODY. 00:49:08.400 --> 00:49:09.400 AND SO KIDS NEED 00:49:09.500 --> 00:49:11.233 TO GET OUT THERE AND EAT SOME DIRT, ROLL AROUND IN 00:49:11.333 --> 00:49:15.167 SOME DIRT, AND NOT HAVE THIS GERMOPHOBIC MINDSET 00:49:15.267 --> 00:49:16.400 OF MANY PARENTS. 00:49:16.500 --> 00:49:18.199 REBECCA: YEAH, YEAH. 00:49:18.299 --> 00:49:21.666 AND I THINK EVEN WITH COVID, PEOPLE GOT EVEN 00:49:21.766 --> 00:49:23.666 WORSE ABOUT ALL OF THAT STUFF. 00:49:23.766 --> 00:49:24.499 DR. BRYAN: EVERYTHING WE WERE DOING 00:49:24.599 --> 00:49:26.333 DURING COVID WAS COUNTERINTUITIVE. 00:49:26.433 --> 00:49:27.400 REBECCA: YEAH. 00:49:27.500 --> 00:49:28.666 DR. BRYAN: YOU KNOW, ANTIBIOTICS FOR A VIRAL 00:49:28.766 --> 00:49:30.133 INFECTION, BY THE WAY. 00:49:30.233 --> 00:49:35.000 UM, ANTISEPTIC MOUTHWASH, USING N-ACIDS. 00:49:35.100 --> 00:49:36.100 EVERYTHING WE WERE DOING. 00:49:36.200 --> 00:49:36.733 SOCIAL -- 00:49:36.833 --> 00:49:37.633 REBECCA: HAND SANITIZER. 00:49:37.733 --> 00:49:39.300 THEY WERE DOING THAT AT MY CHURCH. 00:49:39.400 --> 00:49:42.033 THEY WERE FORCING THE KIDS AND KNOWING WHAT I KNOW, 00:49:42.133 --> 00:49:43.166 I WAS LIKE NO! 00:49:43.266 --> 00:49:44.500 DR. BRYAN: YEAH, AND WEARING MASKS AND BREATHING 00:49:44.600 --> 00:49:46.266 IN YOUR OWN CARBON DIOXIDE 00:49:46.366 --> 00:49:47.500 AND HYPOXIC. 00:49:47.600 --> 00:49:49.300 AND I MEAN, LOOKING BACK, 00:49:49.400 --> 00:49:51.033 IT WAS -- IT'S CRIMINAL. 00:49:51.133 --> 00:49:51.900 THERE'S NO OTHER WORD FOR IT. 00:49:52.000 --> 00:49:53.066 IT'S CRIMINAL. 00:49:53.166 --> 00:49:56.700 REBECCA: AND YOU WERE DURING COVID, TREATING PATIENTS 00:49:56.800 --> 00:50:00.400 WITH NITRIC OXIDE AND YOU WERE SEEING AN IMPROVEMENT, 00:50:00.500 --> 00:50:01.800 BUT THEN YOU HAD PUSHBACK. 00:50:01.900 --> 00:50:03.100 CAN YOU TALK ABOUT? 00:50:03.200 --> 00:50:04.066 DR. BRYAN: YEAH, 00:50:04.166 --> 00:50:05.166 WE HAD A DRUG AS AN EARLY THERAPEUTIC. 00:50:05.266 --> 00:50:07.466 BECAUSE THE CHALLENGE EARLY ON DURING COVID WAS 00:50:07.566 --> 00:50:10.066 HOW DO WE DEVELOP A SAFE AND EFFECTIVE EARLY 00:50:10.166 --> 00:50:12.566 TREATMENT TO KEEP PEOPLE OUT OF THE HOSPITAL? 00:50:12.666 --> 00:50:14.133 BECAUSE EARLY ON, THE ER'S IN THE HOSPITALS 00:50:14.233 --> 00:50:16.166 WERE OVERRUN WITH, WITH PEOPLE AND THEY COULDN'T 00:50:16.266 --> 00:50:17.633 MANAGE AND PEOPLE WERE DYING IN THE STREETS 00:50:17.733 --> 00:50:19.700 ALL OVER THE WORLD. 00:50:19.800 --> 00:50:20.633 SO WE DEVELOPED A -- 00:50:20.733 --> 00:50:22.033 WE WERE FAST-TRACKED FOR THROUGH 00:50:22.133 --> 00:50:25.233 FDA AND WE HAD A DRUG CALLED NITROVERE. 00:50:25.333 --> 00:50:29.167 UM, THAT WE WERE TREATING FOR COVID PATIENTS AND WE 00:50:29.267 --> 00:50:31.299 WOULD TRY TO FIND THEM WITHIN 72 HOURS OF 00:50:31.399 --> 00:50:34.133 DIAGNOSIS OR ONSET OF SYMPTOMS AND TREAT THEM 00:50:34.233 --> 00:50:35.033 WITH NITRIC OXIDE. 00:50:35.133 --> 00:50:36.433 BECAUSE WHAT WE'VE REALIZED EARLY ON 00:50:36.533 --> 00:50:38.033 WAS THAT PEOPLE THAT WERE GETTING SICK AND DYING 00:50:38.133 --> 00:50:41.133 FROM COVID WERE THE PEOPLE WHO COULD NOT MAKE NITRIC OXIDE. 00:50:41.233 --> 00:50:43.366 THE ELDERLY, THE HYPERTENSIVE, THE DIABETICS 00:50:43.466 --> 00:50:46.733 PREVIOUS HEART ATTACK, AFRICAN-AMERICANS, FOR EXAMPLE. 00:50:46.833 --> 00:50:48.267 SO WE THOUGHT IF WE CAN GIVE THEM NITRIC OXIDE 00:50:48.367 --> 00:50:51.467 EARLY ON, WE CAN PREVENT THE VIRUS FROM REPLICATING. 00:50:51.567 --> 00:50:53.133 WE CAN MITIGATE THE VASCULAR INFLAMMATION THAT 00:50:53.233 --> 00:50:54.566 WE WERE SEEING WITH COVID. 00:50:54.666 --> 00:50:56.800 AND WE COULD, WE COULD PROTECT AGAINST 00:50:56.900 --> 00:50:58.966 THE LOSS OF BLOOD OXYGEN SATURATION, 00:50:59.066 --> 00:51:00.800 THE HYPOXIA, THAT ALLOWED FOR 00:51:00.900 --> 00:51:02.233 THE ADMISSION INTO HOSPITALS 00:51:02.333 --> 00:51:04.766 IN THE INTENSIVE CARE UNIT. 00:51:04.866 --> 00:51:05.799 SO WITHIN THE FIRST HUNDRED PATIENTS, 00:51:05.899 --> 00:51:07.033 WE'D ALREADY SEEN A STATISTICALLY 00:51:07.133 --> 00:51:10.400 SIGNIFICANT DIFFERENCE BETWEEN THE GROUP. 00:51:10.500 --> 00:51:11.899 WE ASSUMED THAT THE PEOPLE WERE GETTING BETTER ON THE 00:51:11.999 --> 00:51:14.699 ACTIVE DRUG AND NOT THE PLACEBO. 00:51:14.799 --> 00:51:17.066 AND SO WE PETITIONED THE FDA TO GIVE US EMERGENCY USE 00:51:17.166 --> 00:51:20.633 AUTHORIZATION BECAUSE IT WAS, NUMBER ONE, SAFE. 00:51:20.733 --> 00:51:22.466 BUT NUMBER TWO, IT SEEMED TO BE MAKING PATIENTS 00:51:22.566 --> 00:51:24.799 BETTER AND KEEPING THEM OUT OF THE HOSPITAL. 00:51:24.899 --> 00:51:29.499 AND THIS WAS AFTER THE BIDEN ADMINISTRATION HAD TAKEN 00:51:29.599 --> 00:51:32.066 OVER THE WHITE HOUSE AND THE FDA ADVISED US TO 00:51:32.166 --> 00:51:33.800 CONTINUE THE CLINICAL TRIAL 00:51:33.900 --> 00:51:34.966 TO THE END AND THEN 00:51:35.066 --> 00:51:36.200 OBVIOUSLY COVID CHANGED AND PEOPLE WEREN'T GETTING 00:51:36.300 --> 00:51:37.366 SICK AND GOING TO THE HOSPITAL. 00:51:37.466 --> 00:51:39.233 SO WE HAD TO ABORT THE CLINICAL TRIAL. 00:51:39.333 --> 00:51:41.733 BUT LOOKING BACK, 00:51:41.833 --> 00:51:44.000 THEY WERE NEVER GOING TO APPROVE OUR DRUG BECAUSE 00:51:44.100 --> 00:51:46.267 HAD THEY HAD HAD A SAFE AND EFFECTIVE DRUG FOR 00:51:46.367 --> 00:51:49.033 THERAPY OR FOR COVID ON THE MARKET, 00:51:49.133 --> 00:51:51.366 THEY COULD HAVE NEVER MANDATED THE VACCINES. 00:51:51.466 --> 00:51:54.933 AND AT THAT POINT, AT THAT POINT IN TIME, 00:51:55.033 --> 00:51:58.433 THEY WERE HELL-BENT ON PUSHING FOR VACCINE MANDATES, 00:51:58.533 --> 00:52:00.633 GETTING EVERYBODY IN THE WORLD VACCINATED. 00:52:00.733 --> 00:52:02.367 AND IF WE HAD A SAFE AND EFFECTIVE NITRIC OXIDE 00:52:02.467 --> 00:52:03.500 DRUG ON THE MARKET, 00:52:03.600 --> 00:52:05.633 THEN THEY COULD HAVE NEVER MANDATED THE VACCINES. 00:52:05.733 --> 00:52:08.233 REBECCA: SO HOW DID THEY SHUT YOU DOWN? 00:52:08.333 --> 00:52:09.700 DR. BRYAN: TOLD US TO COMPLETE THE CLINICAL TRIAL. 00:52:09.800 --> 00:52:11.100 KEEP ENROLLING PATIENTS. 00:52:11.200 --> 00:52:12.233 AND WE HAD, YOU KNOW, 00:52:12.333 --> 00:52:15.233 HAD TO ENROLL 840 PATIENTS TO HIT OUR PRIMARY 00:52:15.333 --> 00:52:17.467 ENDPOINT BASED ON THE POWER ANALYSIS. 00:52:17.567 --> 00:52:18.700 BUT, YOU KNOW, LATER DURING COVID -- 00:52:18.800 --> 00:52:19.933 REBECCA: THEY STRUNG YOU ALONG 00:52:20.033 --> 00:52:21.000 TO WHERE IT WAS TOO HARD. 00:52:21.100 --> 00:52:21.866 DR. BRYAN: BECAUSE PEOPLE WEREN'T GETTING SICK 00:52:21.966 --> 00:52:22.600 AND GOING TO 00:52:22.700 --> 00:52:23.466 THE HOSPITAL ANYMORE, RIGHT? 00:52:23.566 --> 00:52:25.200 IT WAS A THREE-YEAR OLD DISEASE. 00:52:25.300 --> 00:52:26.966 THE FEAR, IT KIND OF WANED. 00:52:27.066 --> 00:52:28.633 PEOPLE WERE REALIZING 00:52:28.733 --> 00:52:30.566 IT WAS PROBABLY A CONTRIVED, 00:52:30.666 --> 00:52:34.133 UH, MANMADE PHENOMENON. 00:52:34.233 --> 00:52:36.333 SO THERE WAS LESS FEAR AND LESS PEOPLE 00:52:36.433 --> 00:52:37.233 GOING TO THE HOSPITAL. 00:52:37.333 --> 00:52:39.433 AND IF YOU DIDN'T COMPLETE OUR STUDY, 00:52:39.533 --> 00:52:41.200 IF YOU WEREN'T HOSPITALIZED 00:52:41.300 --> 00:52:45.467 OR ADMITTED TO THE ICU OR YOU DIED, UM, SO 00:52:45.567 --> 00:52:46.599 WE HAD TO ABORT THE STUDY. 00:52:46.699 --> 00:52:47.366 REBECCA: IT'S VERY EXPENSIVE TOO. 00:52:47.466 --> 00:52:48.300 DR. BRYAN: IT'S VERY EXPENSIVE 00:52:48.400 --> 00:52:50.100 TO CONDUCT LARGE-SCALE DRUG STUDIES. 00:52:50.200 --> 00:52:51.966 REBECCA: YEAH, THAT'S CRAZY. 00:52:52.066 --> 00:52:53.733 DR. BRYAN: SO WE STOPPED AND WE TABLED IT 00:52:53.833 --> 00:52:54.699 FOR THE NEXT 00:52:54.799 --> 00:52:56.033 RESPIRATORY VIRUS OUTBREAK. 00:52:56.133 --> 00:52:57.799 BUT WE KNOW, WE'VE GOT A SAFE DRUG PRODUCT. 00:52:57.899 --> 00:52:59.900 AND WE JUST KEEP IT ON THE SHELF TILL THE NEXT ONE 00:53:00.000 --> 00:53:01.767 AND THEN WE'LL WE'LL DEPLOY IT AGAIN. 00:53:01.867 --> 00:53:04.999 REBECCA: HOW DOES IT HELP FIGHT A VIRUS? 00:53:05.099 --> 00:53:06.299 DR. BRYAN: WELL, WE'VE KNOWN FOR PROBABLY 20 00:53:06.399 --> 00:53:07.733 YEARS NOW THAT NITRIC OXIDE 00:53:07.833 --> 00:53:09.233 ACTUALLY PREVENTS A VIRUS FROM 00:53:09.333 --> 00:53:10.500 REPLICATING AND THIS WAS IN... 00:53:10.600 --> 00:53:11.433 REBECCA: REALLY? 00:53:11.533 --> 00:53:13.800 DR. BRYAN: SARS-COV-1 CORONAVIRUS, 00:53:13.900 --> 00:53:16.767 NOT SARS-COV-2 WHICH WAS CORONA. 00:53:16.867 --> 00:53:18.900 BUT DATA AT THE, I BELIEVE, IT 00:53:19.000 --> 00:53:20.200 WAS SWEDEN OR SWITZERLAND, 00:53:20.300 --> 00:53:23.200 SHOWED IN 2005 THAT NITRIC OXIDE PREVENTS 00:53:23.300 --> 00:53:25.233 THE VIRUS FROM REPLICATING. 00:53:25.333 --> 00:53:27.266 SO IN TERMS OF RESPIRATORY, 00:53:27.366 --> 00:53:29.733 THE NORMAL IMMUNE RESPONSE TO VIRUSES. 00:53:29.833 --> 00:53:31.100 WHEN WE'RE EXPOSED TO A VIRUS, 00:53:31.200 --> 00:53:34.666 WHETHER IT'S RSV, INFLUENZA, 00:53:34.766 --> 00:53:37.766 CORONAVIRUS, OUR BODY RECOGNIZES THAT. 00:53:37.866 --> 00:53:38.433 AND IT GOES, 00:53:38.533 --> 00:53:39.366 I'M BEING ATTACKED. 00:53:39.466 --> 00:53:40.333 I GOT TO MOBILIZE AN IMMUNE RESPONSE. 00:53:40.433 --> 00:53:41.233 THE IMMUNE CELLS GO THERE, 00:53:41.333 --> 00:53:42.667 THE SIDE OF ATTACHMENT 00:53:42.767 --> 00:53:44.033 GENERATE A LOT OF NITRIC OXIDE FOR A 00:53:44.133 --> 00:53:45.266 SHORT PERIOD OF TIME AND PREVENT 00:53:45.366 --> 00:53:47.666 THE VIRUS FROM REPLICATING. 00:53:47.766 --> 00:53:50.233 SO THINK ABOUT IT IN THOSE AT-RISK, 00:53:50.333 --> 00:53:51.066 THAT THOSE WHO CAN'T 00:53:51.166 --> 00:53:52.533 MAKE NITRIC OXIDE, NUMBER ONE, 00:53:52.633 --> 00:53:54.433 THEY'VE GOT AN UPREGULATION OF ACE2 RECEPTOR 00:53:54.533 --> 00:53:55.367 WHERE THE CORONAVIRUS, 00:53:55.467 --> 00:53:57.266 THE SPIKE PROTEIN BINDS TO. 00:53:57.366 --> 00:53:59.566 SO THERE'S MORE ATTACHMENT SITES FOR THE VIRUS TO 00:53:59.666 --> 00:54:02.067 ENTER AND TO PENETRATE THE CELL. 00:54:02.167 --> 00:54:03.766 SO THAT'S NITRIC OXIDE DEFICIENCY. 00:54:03.866 --> 00:54:05.933 THEY'RE MORE SUSCEPTIBLE TO VIRAL 00:54:06.033 --> 00:54:09.867 INFECTIONS BECAUSE OF THAT UPREGULATION OF CERTAIN 00:54:09.967 --> 00:54:12.300 RECEPTORS THAT VIRUSES BIND TO. 00:54:12.400 --> 00:54:12.933 SO IN PEOPLE WHO 00:54:13.033 --> 00:54:13.967 CAN'T MAKE NITRIC OXIDE, 00:54:14.067 --> 00:54:15.333 THEY GOT MORE TARGET, MORE 00:54:15.433 --> 00:54:17.833 ENTRIES OF ENTRY OR MORE PORTS OF ENTRY INTO THE 00:54:17.933 --> 00:54:19.333 CELL BY THE VIRUS. 00:54:19.433 --> 00:54:21.999 AND THEN YOU CAN'T MOBILIZE AN IMMUNE RESPONSE. 00:54:22.099 --> 00:54:23.999 AND SO BY THAT TIME, THE VIRUS HAS TAKEN 00:54:24.099 --> 00:54:24.700 OVER IN THE CELL. 00:54:24.800 --> 00:54:26.367 IT'S RAPIDLY REPLICATING. 00:54:26.467 --> 00:54:28.100 IT'S PROPAGATING THROUGHOUT THE BODY, 00:54:28.200 --> 00:54:30.199 RELEASING THE SPIKE PROTEIN, CAUSING VASCULAR 00:54:30.299 --> 00:54:32.500 INFLAMMATION, CAUSING PLATELETS TO AGGREGATE, 00:54:32.600 --> 00:54:36.267 MICROCLOTS, BREAK THEM DOWN, ELEVATION AND D-DIMERS. 00:54:36.367 --> 00:54:37.833 THERE'S YOUR LONG-COVID PATIENT AND THERE'S YOUR 00:54:37.933 --> 00:54:40.267 SYSTEMIC DISEASE FROM A RESPIRATORY INFECTION. 00:54:40.367 --> 00:54:42.366 REBECCA: HAS THIS HELPED PEOPLE WITH LONG COVID? 00:54:42.466 --> 00:54:43.033 DR. BRYAN: ABSOLUTELY. 00:54:43.133 --> 00:54:44.400 REBECCA: OH, THAT'S HUGE. 00:54:44.500 --> 00:54:45.200 DR. BRYAN: BECAUSE THE PROBLEM IS, 00:54:45.300 --> 00:54:45.900 LOOK, YOU'VE GOT 00:54:46.000 --> 00:54:47.433 THE VASCULAR INFLAMMATION. 00:54:47.533 --> 00:54:48.533 SEVERAL OF MY PATENTS ARE 00:54:48.633 --> 00:54:50.799 ON A METHOD OF REDUCING VASCULAR INFLAMMATION. 00:54:50.899 --> 00:54:52.966 SO NITRIC OXIDE LOWERS THE INFLAMMATION, 00:54:53.066 --> 00:54:55.299 DOWNREGULATES THE ACE2 RECEPTORS. 00:54:55.399 --> 00:54:58.333 SO THERE'S LESS TARGET FOR THE SPIKE PROTEIN TO BIND TO, 00:54:58.433 --> 00:55:00.200 PREVENTS PLATELETS FROM BECOMing ACTIVATED, 00:55:00.300 --> 00:55:03.033 PREVENTS PLOT FORMATION OR CLOT FORMATION. 00:55:03.133 --> 00:55:03.766 REBECCA: THAT'S -- 00:55:03.866 --> 00:55:04.833 DR. BRYAN: AND THAT'S HUGE. 00:55:04.933 --> 00:55:06.666 I MEAN, PEOPLE DIED FROM HEART ATTACK, STROKE, 00:55:06.766 --> 00:55:10.133 FROM THESE MASSIVE CLOTS BASED ON AUTOPSY REPORTS. 00:55:10.233 --> 00:55:12.299 REBECCA: YEP, THERE WAS A HUGE UPTAKE 00:55:12.399 --> 00:55:15.200 IN PEOPLE GETTING HEART PROBLEMS. 00:55:15.300 --> 00:55:17.067 I MEAN, TONS OF PEOPLE. 00:55:17.167 --> 00:55:19.033 IS THERE ANY -- HAVE YOU SEEN 00:55:19.133 --> 00:55:22.766 ANY IMPROVEMENT WITH CANCER WITH NITRIC OXIDE? 00:55:22.866 --> 00:55:24.000 DR. BRYAN: YOU KNOW, THERE'S TWO CAMPS OUT 00:55:24.100 --> 00:55:25.100 THERE IN CANCER. 00:55:25.200 --> 00:55:28.266 CANCER IS A PRETTY COMPLEX DISEASE TO ME. 00:55:28.366 --> 00:55:30.199 CANCER IS A METABOLIC DISEASE. 00:55:30.299 --> 00:55:31.366 CANCER ONLY GROWS 00:55:31.466 --> 00:55:34.799 IN A LOW OXYGEN, LOW PH, LOW VOLTAGE ENVIRONMENT. 00:55:34.899 --> 00:55:36.466 AND THAT'S CALLED -- WE CALL THAT THE WARBURG EFFECT. 00:55:36.566 --> 00:55:37.967 YOU KNOW, OTTO WARBURG WON A NOBEL PRIZE... 00:55:38.067 --> 00:55:39.400 REBECCA: YEAH. 00:55:39.500 --> 00:55:40.966 DR. BRYAN: I THINK THE 1930S FOR THE DISCOVERY 00:55:41.066 --> 00:55:42.933 THAT CANCER IS A METABOLIC DISEASE. 00:55:43.033 --> 00:55:44.600 AEROBIC FERMENTATION, UNCOUPLED 00:55:44.700 --> 00:55:46.833 ELECTRON TRANSPORT CHAIN, AND THAT CREATES AN 00:55:46.933 --> 00:55:48.733 ENVIRONMENT FOR CANCER CELLS TO RAPIDLY 00:55:48.833 --> 00:55:52.333 PROLIFERATE AND GROW AND FORM A PRIMARY TUMOR. 00:55:52.433 --> 00:55:55.033 SO THE THOUGHT PROCESS IS IN 00:55:55.133 --> 00:55:56.666 A PRIMARY TUMOR ENVIRONMENT, 00:55:56.766 --> 00:55:57.633 YOU NEVER WANT TO GIVE 00:55:57.733 --> 00:56:00.033 A WHAT'S CALLED A PROANGIOGENIC FACTOR. 00:56:00.133 --> 00:56:02.100 MEANING A MOLECULE THAT CAN INDUCE 00:56:02.200 --> 00:56:04.366 VASCULARGENESIS and ANGIOGENESIS. 00:56:04.466 --> 00:56:06.633 BECAUSE IT WAS THOUGHT THAT YOU COULD GROW NEW BLOOD VESSELS TO 00:56:06.733 --> 00:56:11.833 THAT HYPOXIC TUMOR, AN INDUCED METASTATIC DISEASE. 00:56:11.933 --> 00:56:13.666 THAT'S ONE CAMP. 00:56:13.766 --> 00:56:17.300 MY CAMP IS THAT BECAUSE A PRIMARY TUMOR IS LOW 00:56:17.400 --> 00:56:19.967 OXYGEN, LOW PH, LOW VOLTAGE, 00:56:20.067 --> 00:56:21.100 NITRIC OXIDE IS THE 00:56:21.200 --> 00:56:22.533 ANTIDOTE TO THAT, RIGHT? 00:56:22.633 --> 00:56:23.367 WHAT DOES NITRIC OXIDE DO? 00:56:23.467 --> 00:56:24.433 DILATES THE BLOOD VESSELS, 00:56:24.533 --> 00:56:26.700 OXYGENATES THE TISSUE, RECOUPLES 00:56:26.800 --> 00:56:28.533 THE ELECTRON TRANSPORT CHAIN. 00:56:28.633 --> 00:56:29.400 REBECCA: YEAH. 00:56:29.500 --> 00:56:30.100 DR. BRYAN: IT'S A FREE RADICAL, 00:56:30.200 --> 00:56:30.766 SO IT DONATES AN ELECTRON. 00:56:30.866 --> 00:56:32.200 IT INCREASES THE VOLTAGE 00:56:32.300 --> 00:56:33.467 IN THAT ENVIRONMENT. 00:56:33.567 --> 00:56:34.333 SO EVERYTHING THat NITRIC 00:56:34.433 --> 00:56:37.633 OXIDE IS AND DOES IS ANTI-CANCER. 00:56:37.733 --> 00:56:38.533 REBECCA: WOW. 00:56:38.633 --> 00:56:39.233 DR. BRYAN: BUT YOU HAVE TO ADDRESS 00:56:39.333 --> 00:56:40.600 WHY THAT PRIMARY TUMOR GREW 00:56:40.700 --> 00:56:42.000 IN THE FIRST PLACE. 00:56:42.100 --> 00:56:43.000 THERE'S A WHOLE OTHER DISCUSSION... 00:56:43.100 --> 00:56:44.066 REBECCA: YEAH. 00:56:44.166 --> 00:56:45.267 DR. BRYAN: ON THAT, BUT TREATING THE CANCER 00:56:45.367 --> 00:56:45.967 IN AN OXYGENATED 00:56:46.067 --> 00:56:48.033 AND HYPOXIC PRIMARY TUMOR, 00:56:48.133 --> 00:56:49.533 I THINK IS THE BEST MEDICINE. 00:56:49.633 --> 00:56:50.933 REBECCA: THAT'S AMAZING. 00:56:51.033 --> 00:56:52.500 WELL, THIS, WELL, 00:56:52.600 --> 00:56:54.599 I'M TAKING THIS PRODUCT. 00:56:54.699 --> 00:56:56.733 THIS HAS BEEN SUCH AN INCREDIBLE CONVERSATION. 00:56:56.833 --> 00:56:59.333 THANK YOU SO MUCH FOR YOUR WORK AND YOUR DEDICATION. 00:56:59.433 --> 00:57:01.033 THANK YOU FOR NOT GIVING UP WHEN THINGS WERE 00:57:01.133 --> 00:57:06.067 DIFFICULT AND KEEP GOING AND KEEP MAKING PRODUCTS. 00:57:06.167 --> 00:57:08.700 AND COME BACK AND WE CAN TALK ABOUT MORE THINGS. 00:57:08.800 --> 00:57:09.466 DR. BRYAN: YEAH, THANK YOU, REBECCA. 00:57:09.566 --> 00:57:10.533 IT'S BEEN A GREAT PLEASURE. 00:57:10.633 --> 00:57:11.366 REBECCA: IT'S BEEN AWESOME. 00:57:11.466 --> 00:57:12.700 THANK YOU SO MUCH, DOCTOR. 00:57:12.800 --> 00:57:13.066 DR. BRYAN: THANK YOU.